Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
'Most of these studies have focused on immune checkpoint blockade, although effects of the microbiota on clinical outcomes have also been observed in allogeneic hematopoietic stem cell transplant (which can be considered a very broad form of #immunotherapy).'
Thiago Carvalho
boosted
#UNESCO just launched a survey calling for #BestPractices in #OpenScience.
https://forms.office.com/pages/responsepage.aspx?id=Uq5PHbM5-kuwswIpVrERlFtomJyhGNxAj5kDjhIGW4ZUNFlRQzhVRkNOR1FBMDhKOEhCTUFTOVVVVC4u
The survey is best suited to submit just one idea at a time. If you plan to fill it out, be ready to answer four essay-type questions and to include cost estimates and URLs.
Thiago Carvalho
boosted
'It took García Márquez only 18 months to write “Solitude,” though he spent nearly two decades mulling the story in his head. While reading proofs of his novella “Leaf Storm” — an early testing ground for Macondo and its characters — he remarked to his brother, “This is good, but I’m going to write something that people will read more than the Quixote.” He wasn’t far off.'
https://www.nytimes.com/article/gabriel-garcia-marquez-books.html
Thiago Carvalho
boosted
'Limitations in animal models that fail to recapitulate the features of progressive MS provide an immediate dilemma in linking physiologic and pathologic states and in translating preclinical findings to the clinic.'
Thiago Carvalho
boosted
'As the new coronavirus spread, pandemic-mitigation measures started to squash flu-transmission rates to record lows. The drop-off was so sharp that several flu lineages may have gone extinct, among them Yamagata, which hasn’t been definitively detected in more than three years despite virologists’ best efforts to root it out.'
Thiago Carvalho
boosted
Our new paper in @JAMA: Population-Level Health Effects of Involuntary Displacement of People Experiencing Unsheltered Homelessness Who Inject Drugs in US Cities led by @jabarocas along with the dream team of @BenjaminLinas, @jesselloyd_g, @sammy23_16, @alexhkral, @DrSarahAxelrath, @RNBluthenthal, @ashleyameehan, @AlSavinkina, @AlainaBoyer3, @jchiang22
https://jamanetwork.com/journals/jama/fullarticle/2803839
That's an impressive nosedive in fig 1 of this Nature Biotech piece (# of IPOs).
'To attract funding in 2023, biotechs need strong data (ideally clinical data), a differentiated asset or technology, disciplined spending, sensible time frames and realistic valuation expectations. Such basics were forgotten during the upturn, and inflated private valuations persisted beyond it — partly explaining the lower investment and merger and acquisition activity during 2022.'
Thiago Carvalho
boosted
Taxonomically Restricted Genes in Bacillus may Form Clusters of Homologs and Can be Traced to a Large Reservoir of Noncoding Sequences https://doi.org/10.1093/gbe/evad023 #science #evolution #biology #genome #SciComm #evolgen_paper
'The authors evaluated 29 anticancer drugs that received a first marketing authorisation for 32 separate cancer indications in 2017-19. Most (23/32, 72%) of the indications were not associated with any direct survival benefit; instead, approval was on the basis of surrogate outcomes, such as progression-free survival or tumour response.'
Thiago Carvalho
boosted
At the 2023 AAAS meeting, we learned about several successful pilot projects that offer models for drawing non-scientists into the conversation about how science is created, applied, and given priority. https://www.dana.org/article/building-trust-breaking-down-barriers/
#neurosociety #neuroethics #scicomm #outreach #neuroscience #brainscience #brainhealth #brain #AAASmtg
Photo courtesy of @ZuckermanBrain
'The report states “Genentech scientists and research associates had difficulty reproducing certain results reported in the 2009 Nature paper, in particular, the binding interaction between DR6 and N-APP.”
Thiago Carvalho
boosted
'Montmartre. Intérieur du cabaret L'Enfer, jumeau de celui du Ciel, 53, boulevard de Clichy. Paris (XVIIIème arr.), 1904. '
"An Alzheimer's disease-specific pattern of cytokine secretion reduces expression of mitochondrial electron transport complexes and impairs mitochondrial respiration in healthy neurons."
'Our study reveals that probiotic Lactobacillus reuteri (Lr) translocates to, colonizes, and persists within melanoma, where via its released dietary tryptophan catabolite I3A, it locally promotes interferon-γ-producing CD8 T cells, thereby bolstering ICI.'
Thiago Carvalho
boosted
RT @nromberg_
Out now in @SciImmunology! We explored an essential question in the field of human immunology: what keeps germinal center (GC) responses focused on foreign-antigens and away from self-antigens? A🧵 1/7 https://www.science.org/doi/10.1126/sciimmunol.ade8162#.ZDBrqaNe2HU.twitter
Thiago Carvalho
boosted
RT @alanmcn1
Two days left to apply for this 4 year post doc in our lab working on clinical metagenomics
Thiago Carvalho
boosted
📷 La photographe @karen1knorr est de passage à Paris, Galerie Les filles du calvaire, pour un «panorama» de son œuvre sophistiquée, qui traverse des salons bourgeois ou palais indiens où surgissent des animaux incongrus. ➡️ https://www.liberation.fr/culture/photographie/la-photographe-karen-knorr-dans-le-bestiaire-du-temps-20230409_Y5SL542IZNAY5IYLUUU5TDY7FA/
"A federal judge in Texas has taken a shocking and irresponsible action:invalidating the Food and Drug Administration’s approval of mifepristone, a medication used safely by hundreds of thousands of women each year to help terminate pregnancies as part of a two-pill regimen."
https://www.nytimes.com/2023/04/10/opinion/fda-mifepristone.html
Thiago Carvalho
boosted
RT @mneiman
Interested in learning more about #preprints and publishing? The #ProcB Editorial Preprint Team is now recruiting #ECR to assess preprints for potential submission to Proceedings B. We are especially focused on increasing diversity in our membership... 🧵1/3
'Using single i-cell transplantation from transgenic fluorescent donors to wild-type recipients, we find that these cells are pluripotent. Under physiological conditions, a single i-cell can differentiate into all somatic cell types and into gametes. The presence of embryonic-like, pluripotent cells throughout adult life facilitates their ability to grow indefinitely in a plant-like fashion.'
https://www.cell.com/current-biology/fulltext/S0960-9822(23)00404-9
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
