Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Streptomyces spp. as biocatalyst sources in pulp and paper and textile industries: Biodegradation, bioconversion and valorization of waste

@MicrobialBiote1 by @mcuebs and Amy M Grunden @NCState

https://ami-journals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.14258?campaign=wolearlyview

For Throwback Thursday, an #EMBOPodcast episode with Akiko Iwasaki at the start of Covid year 2 (2021). We talked about the pandemic of course, but a lot more. Including her Immunology course at Yale.

"Ruslan (Medzhitov) and I have worked together to construct a course of introductory #immunology for medical students over the last several years. We wanted to approach immunology from first principles, not throwing some CD numbers and IL-whatever at the students, but really starting form how the system is established, how it works, what detection systems there are, and the arsenal of immune effector functions that are used to fight infection."

https://www.embo.org/podcasts/the-right-place-at-the-right-time/

A new preprint from Ainsley Lockhart & @mucida has, as the cool kids say, just dropped:

"Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells"
#immunology #MucosalImmunology #preprint

https://www.biorxiv.org/content/10.1101/2023.04.11.536475v1?med=mas

Aux Deux Magots.

#SimoneDeBeauvoir by #RobertDoisneau.

He was born #otd 111 years ago, she left us 37 years ago.

#photography #photodons #portrait

Assistant Professorship tenure track in Analysis

The Faculty of Science at the University of Zurich (UZH) invites applications for the Assistant Professorship tenure track in Analysis.

https://jobrxiv.org/job/university-of-zurich-faculty-of-science-27778-assistant-professorship-tenure-track-in-analysis/?feed_id=42426

#ScienceJobs #job
Zurich #Switzerla...
https://jobrxiv.org/job/university-of-zurich-faculty-of-science-27778-assistant-professorship-tenure-track-in-analysis/?feed_id=42426

Best opening line of a paper I've read in a while:

"The analogy of mitochondria as powerhouses has expired."

Interesting review on mitochondria signal transduction from Martin Picard (http://www.picardlab.org/):

https://www.sciencedirect.com/science/article/pii/S1550413122004594?via%3Dihub

Learned so much (and had a lot of fun) from talking w @mkirschenbaum for #scholarlykitchn -- about writing, technology and the "gray goo" of AI-- spurred by his Atlantic essay "Textpocalypse." #ChatGPT #bookhistory #humanities #scholcomm https://scholarlykitchen.sspnet.org/2023/04/13/textpocalypse-a-literary-scholar-eyes-the-grey-goo-of-ai/

Brexanolone is administered as an iv infusion over a 60 hour period (in a hospital setting).

As Pam Belluck of the NYT had noted in 2019, making an orally available form was the clear next step.

"A pill made with a similar molecule, which would be much more accessible and easier for patients, is showing promise in its clinical trials and would be submitted for approval in a couple of years if the results are good, according to Sage."

https://www.nytimes.com/2019/03/19/health/postpartum-depression-drug.html

The topic of my latest #NatureMedicine Clinical Pipeline column, zuranolone, represents an improvement in both safety & ease of administration over its on its predecessor, brexanolone (which was the first drug approved specifically for postpartum depression in 2019). The case for it in major depressive disorder is more complex.

https://www.nature.com/articles/d41591-023-00032-8

"Maps 6 & 9. The Origami Maps (Dresden, 1914-1918)

These maps, or objects, represent the sole known instance of an attempt at creativity by the Margrave. Like so many Europeans of his generation, von Willebrand was enthralled by Japanese art, and he developed a particular fascination with origami – a set of techniques with ancestral origins in Japan whose basic principles influenced the “folds of truth, folds of life and folds of beauty” ideas of German pedagogue Friedrich Fröbel.
Tragically, von Willebrand brought his newfound creativity to bear on the problems of cryptography – the Margrave was ever mindful of his duty to the Fatherland. von Willebrand’s work on the tactical applications of origami in the battlefield somehow managed to pique the interest of the Kaiser’s father, Frederick III, during his brief 99-day reign. When Frederick died, his relationship with the Margrave ultimately led his son Kaiser Wilhelm II to authorize a field test of the origami system during the Third Battle of Ypres. As a result, an entire German reconnaissance platoon was picked off one by one by a perplexed British sniper as they tried to fold paper while wearing full anti-gas gear."

#prints #Printmaking #cartography #handmade #artmastodon #artgallery #origami #origamiart

https://madalenaparreira.com/SPAM

"These drugs (such as semaglutide, which is Ozempic/Rybelsus/Wegovy) are famous now because of the huge impact they’ve made in the obesity market, and the market is increasing every day. We’re going to have a lot more people taking these drugs, and we may find out a lot more about them in the process."

https://www.science.org/content/blog-post/ozempic-and-other-glp-1-drugs-more-people-realize