Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"The first successful in-vitro fertilization, in 1978, made it possible to conceive an embryo outside the body. Today, approximately two per cent of all babies in the United States are conceived in a lab, through I.V.F.—last year, analysts valued the global I.V.F. market at more than twenty-three billion dollars."

https://www.newyorker.com/magazine/2023/04/24/the-future-of-fertility

'Studies herein with Salmonella demonstrate that the interactions of structurally related, but functionally unique, α-helical Gre factors with the secondary channel of RNA polymerase elicit the expression of metabolic signatures that are associated with resistance to oxidative killing.'
#Microbiology #HostPathogen

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002051

"When we hear a great talk, we recognize how we may be able to use the conclusions (and whether we want to), integrating them into how we think about, well, everything pertaining to the subject at hand. The same conclusions, offered during a bad or mediocre version of the talk, may well lose this potential (unless the listener works very hard to ignore the distractions of the presentation to reach the conclusions from the data alone). When we leave a really great seminar, we can understand and communicate those conclusions."

https://journals.biologists.com/jcs/article/136/7/jcs261147/306217/We-need-to-talk

This makes sense - PD1/PDL1 are great targets, but the degree of dominance over the last decade was worrisome. Great to see more diversity

"Our current analysis of global IO clinical trials shows that the field took a turn in 2022 with respect to previous years. After more than a decade of an upward trajectory, we notice a decrease in new clinical trials, a shift driven largely by the reduction in phase II studies using anti-PD1/PDL1 mAbs."
#immunology #immunotherapy #immunooncology

https://www.nature.com/articles/d41573-023-00066-0

"Depletion of mTECs showed an effect on Treg production quantitatively and qualitatively more profound than that of DCs followed by the development of distinct organ-specific autoimmune lesions in the hosts."

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2200780/263620/Cooperative-but-Distinct-Role-of-Medullary-Thymic?redirectedFrom=fulltext

'Using fluorescence microscopy, we show that B. burgdorferi associates with mouse and human cells in culture, and we document that internalized spirochetes colocalize with the pattern recognition receptor cyclic GMP-AMP synthase (cGAS).'

#Immunology #InnateImmunity #Borrelia #HostPathogen

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2200354/263621/Borrelia-burgdorferi-Engages-Mammalian-Type-I-IFN?redirectedFrom=fulltext

I have to say this sounds more appealing than another 12 to 14 hour Marvel or Tolkien adaptation:

"Yet here he is again, resurrected by a glorious, vamping Nicolas Cage, swinging a cape, baring his fangs and stealing his every scene. The Count is playing second banana in “Renfield,” but he’s nevertheless a main attraction in this cheerfully disposable entertainment, which perfectly understands that sometimes all you want from a movie is 93 minutes of well-wrought absurdity."

https://www.nytimes.com/2023/04/13/movies/renfield-review-dracula-nicolas-cage.html?action=click&module=Well&pgtype=Homepage&section=Movies