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@CastlTrAstonDrs Not only relevant for #breastcancer but also for #colorectalcancer and more...central not only to bone metabolism but also relevant for the immune system...so consider Vit D levels in #cancer patients, even if they are exposed to the sun daily... @cyrilpedia #immunology

@biorxivpreprint Modulation of immune surveillance occuring during metastatic progression is still a major issue in #cancer #Immunology...and a recurring "smoking gun" are #macrophages and other #myeloidcells ...also here in this experimental model that uncovered a TLR-NFκB myeloid inflammatory program which correlates with pre-metastatic #niche formation and reflects similar signatures of CD14+ 'activated' myeloid cells in the primary tumor @cyrilpedia

If thoughts and prayers did any good, all of mine would have seen Ted Cruz lose his job long ago.

@gpollara @cyrilpedia @mucida Is absolutely intriguing... maybe #monocytes are compartimentalized in a way that the differential IL-24 profile can associated... #immunology

@cyrilpedia @gpollara @mucida And it also may be the link between #interferons , IL-10 and IL-1 bringing innate and adaptive #immunity together ...and very precise to point out the epidermal vs dermal compartimentalization @gpollara

I wrote this little program to visualise biological tracking data from #microscopy. We used it a lot for sense checking and verifying a lot of our data, but sadly it won't make it into our next paper. Anyway, today I tidied it up a bit and will make it available with all the rest of the code for others to use.

#reproducibility #CellBiology #ScienceMastodon

#cancerresearch #Cancerepidemiology #breastcancer Patients with low baseline Vit D levels had a larger tumor size, more positive lymph nodes & were diagnosed at a later stage. Following follow-up,Vit-D deficiency was associated with a significantly increased risk of bone metastases .As result vit D can be used as a prognostic factor in breast cancer patients
📌 sciencedirect.com/science/arti
📌 sciencedirect.com/journal/canc

This is an outstanding reply to, and analysis of that Pamela Paul column in the New York Times that began this way:

"A paper that says science should be impartial was rejected by major journals. You can’t make this up."

Dave Karpf, an academic, takes it apart. He also testifies as a particiant in the peer review system. Worth your time.

davekarpf.substack.com/p/pamel

#nytimes #journalism #peerreview #science

#OtD 7 May 1945 Nazi Germany surrendered unconditionally, leading to the end of WWII in Europe. But many fascists were reinstalled into positions of power without punishment, especially in West Germany and Greece, as well as Bulgaria and Hungary

In March, more than 100 years after insulin was developed, manufacturers announced price reductions for insulin products. Pressure to reduce prices had long been building, so why would they act now? Read @leemoredafny's Perspective: nej.md/3KXP1F0

"It is conceivable that, although extensive genetic and epigenetic evolution occurs within cancer models, such evolution might not translate into biologically meaningful cellular properties. That is, this phenomenon could represent a molecular curiosity with little practical implication. Unfortunately, this does not seem to be the case. Genomic changes that arise throughout model propagation have been associated with marked phenotypic changes across all cancer model types"

nature.com/articles/s41568-018

Jack promoting RFK Jr. on Bluesky demonstrates that Bluesky intends to best Twitter in key time-to-enshitification metric.

'In Japanese, human survivors of the atom bomb are called hibakusha. These surviving trees have a name as well: hibakujumoku.'

nytimes.com/2023/05/05/opinion

'Their work paved the way for companies such as GSK, Pfizer and Moderna to develop the RSV vaccines in the pipeline today. “This is my lifetime's work. It’s very gratifying to see this finally happening,” Graham says. “It’s a good day for RSV.”

nature.com/articles/d41586-023

“Older adults, in particular those with underlying health conditions, such as heart or lung disease or weakened immune systems, are at high risk for severe disease caused by RSV,” said Dr. Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, in a statement. “Today’s approval of the first RSV vaccine is an important public health achievement to prevent a disease which can be life-threatening and reflects the FDA’s continued commitment to facilitating the development of safe and effective vaccines for use in the United States.”

edition.cnn.com/2023/05/03/hea

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