Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'We are starting a clinical trial where 50 patients will be treated with the antiviral drug Paxlovid and 50 will be given a placebo. This is to probe whether persistent virus infection may be causing long Covid in a subset of people. We’re not giving them the conventional five-day course, but a 15-day course of treatment, to see if that can eliminate the source of the problem, which is the remnants of replicating virus'

https://www.theguardian.com/society/2023/may/27/immunologist-akiko-iwasaki-we-are-not-done-with-covid-not-even-close

Pathogenic forms of the ANT1 protein lead to harmful consequences in yeast and mice by clogging the channels that allow mitochondria to import proteins. https://elifesciences.org/digests/84330/a-novel-way-to-cause-disease?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Postdoctoral Scientist - Cell Cycle/Cell Metabolism

Nationwide Children's Hospital

Post-Doctoral Researcher Fellow or Research Associate positions are available in the Center for Childhood Cancer and Blood Diseases.

See the full job description on jobRxiv: https://jobrxiv.org/job/nationwide-childrens-hospital-27778-postdoctoral-scientist-cell-cycle-cell-metabolism/?...
https://jobrxiv.org/job/nationwide-childrens-hospital-27778-postdoctoral-scientist-cell-cycle-cell-metabolism/?feed_id=46669

Wow, those are some high #ciclosporine levels at baseline!

#transplantation #nephrology

Evaluation of drug interaction between cyclosporine and lercanidipine: a descriptive study https://pubmed.ncbi.nlm.nih.gov/37236776/?utm_source=Feedly&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1pq-4TZ0w1pCinD_GHL9_2WNbZ7J_Sy6TyOPWav10SQEpUpQS6&fc=20230515214155&ff=20230527124951&v=2.17.9.post6+86293ac

Master or PhD positions

University of Ottawa

Master and PhD in #Canada fully funded positions in #bioinformatics

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-ottawa-27778-master-or-phd-positions/?feed_id=46627

#ScienceJobs #hiring #research #bioinformatics #machine learning
Ottawa #Canada #PhDStudent #ResearchAssistant
https://jobrxiv.org/job/university-of-ottawa-27778-master-or-phd-positions/?feed_id=46627

Great opening by Carolyn Wilke:

"Costello the octopus was napping while stuck to the glass of his tank at the Rockefeller University in New York. He snoozed quietly for half an hour, and then entered a more active sleep stage, his skin cycling through colors and textures used for camouflage — typical behavior for a cephalopod.
But soon things became strange."

https://www.nytimes.com/2023/05/25/science/octopus-nightmare-dream.html

If you're in Lisbon, @joanagsa @JoanaLA & I will discuss the importance of failure in scientific progress & what this means for how we design our research institutions.

This Sunday, at Feira do Livro

Postdoc position - Lipid Network Reconstruction & Computational Modeling

Osnabrück University

The Holthuis Lab at Osnabrück University is looking for a Postdoc to work on LIPID NETWORK RECONSTRUCTION & COMPUTATIONAL MODELING FOR IMDs

See the full job description on jobRxiv: https://jobrxiv.org/job/osnabruck-university-27778-postdoc-position-lipid-network-r...
https://jobrxiv.org/job/osnabruck-university-27778-postdoc-position-lipid-network-reconstruction-computational-modeling/?feed_id=46620

'El gran peligro, coinciden los expertos, es que una vez que las vacunas estén firmemente establecidas en África, y los casos y muertes empiecen a descender, el riesgo de resurgimiento de la malaria será alto. Bawa recuerda que “la historia ha demostrado que esto es lo que ocurrió en Latinoamérica y otras partes del mundo que llegaron a un buen punto y entonces se relajaron, y antes de que se dieran cuenta, se produjo un rebrote”.

#malaria

https://elpais.com/planeta-futuro/red-de-expertos/2023-05-25/las-nuevas-vacunas-contra-la-malaria-un-exito-con-algunas-sombras.html

Ooops indeed:

"In other words, the university had patted itself on the back for helping postdocs find a place to live, but its solution turned out to financially exclude, you know, postdocs. Oops!"

https://www.science.org/content/article/when-universities-are-theme-parks-postdocs-and-grad-students-suffer

The new oral vaccine for type 2 #polio is a lot safer than the Sabin vaccine it has replaced. But it may not be quite as effective, and it will not solve all the eradication program's problems, some campaign veterans warn. #nOPV2 https://www.statnews.com/2023/05/26/some-hoped-a-new-oral-vaccine-would-solve-all-the-polio-campaigns-problems-reality-is-settling-in/

"Anthropocene 'sixth mass extinction' event predicted to be worse than previously thought"
https://phys.org/news/2023-05-anthropocene-sixth-mass-extinction-event.html

The paper: "More losers than winners: investigating Anthropocene defaunation through the diversity of population trends" by Finn, Grattarola and Pincheira-Donoso 2023 https://onlinelibrary.wiley.com/doi/full/10.1111/brv.12974

Causes: not really #GlobalWarming/#ClimateChange but rather from #EcosystemCollapse and #Ecocide–the sistematic dismantling of Earth's ecosystems–, and primarily from our present approach to food production and consumption.

Meanwhile, most of us continue to commute by car, consume red meat, fly for holidays and work, and in other words, pretend this `problem` clearly somebody else must be solving, or there isn't a problem at all because this very minute we aren't inconvenienced by it.