Thiago Carvalho @cyrilpedia@social.cleverlibre.org

There's more to gasdermin than just proptosis.

'Our study supports that differential cleavage of GSDMD can be understood as a regulatory hub controlling immunity versus tolerance in the small intestine.'
#Immunology #mucosalimmunology

https://www.cell.com/cell/fulltext/S0092-8674(23)00577-9

'The results highlight how widely and unpredictably disease severity and contagiousness vary between people. “And it’s that variability among humans that has made this virus so difficult to control,” says infectious-disease doctor Monica Gandhi at the University of California, San Francisco, who was not involved in the work. The study, published on 9 June in Lancet Microbe, also suggests that human physiology, not the virus, is to blame for some of the inconsistency of COVID-19'

https://www.nature.com/articles/d41586-023-01961-7

'As science becomes increasingly accessible to the general public, racist agendas can now more easily use science to disinform. All scientists must pursue and accomplish anti-racism efforts to achieve change at the system level. Juneteenth can remind us of what we still need to change, but doing so requires action from funding bodies, institutions, and the wider community.'

https://www.cell.com/cell/fulltext/S0092-8674(23)00536-6

JM Keynes FTW

"He championed better statistics and secured the appointment of a statistician to the department, but he also came to doubt the excessive claims statisticians made for quantitative knowledge. Too often, he thought, they slid unwittingly from precise description to sweeping interpretation. Numbers were essential to knowledge, but when they acquired a fetish-like quality they led to intellectual laziness—creating an aura of precision around unwarranted claims, fostering fantasies of control over the future."

https://www.commonwealmagazine.org/john-maynard-keynes-economics-uncertainty-woolf-lears

'Stanford’s railroad companies employed 10,000 to 12,000 Chinese laborers, whom they exploited even more brutally than they did the smaller number of mostly Irish white immigrant workers. To lay the rails and build stations, they displaced Native Americans from their lands: the federal Pacific Railway Act of 1862 undertook to “extinguish as rapidly as may be the Indian titles to all lands falling under the operation of this act.” The journalist and writer Ambrose Bierce called the Big Four the “rail-rogues” and referred to Leland Stanford as “Stealand Landford.”

https://www.nybooks.com/articles/2023/06/22/a-poisonous-legacy-who-killed-jane-stanford/

'People have been vaccinating domesticated animals for centuries, but only two reasons justify immunizing wildlife, says Tonie Rocke, a research scientist at the U.S. Geological Survey: “to prevent spillover to domestics and humans of a zoonotic disease, and for conservation purposes.”

https://www.theatlantic.com/science/archive/2023/06/vaccinating-wildlife-population-disease-bird-flu/674399/

Pause

https://www.youtube.com/watch?v=KXNKQhFUhiE

I love it when authors include the proper primary references:

"The discovery of dead, fungus-covered flies in elevated locales has fascinated the scientifically curious for at least the past 150 years (Berisford and Tsao, 1974; Cohn, 1855; Gryganskyi et al., 2013; Mullens et al., 1987)."

"For at least two centuries, scientists have been enthralled by the “zombie” behaviors induced by mind-controlling parasites. Despite this interest, the mechanistic bases of these uncanny processes have remained mostly a mystery."

https://elifesciences.org/articles/85410

The view from the new terrace at EMBO #Heidelberg

'The analyses of RANK and RANKL expression in large cohorts of breast cancer samples and functional studies in RANK+ breast cancer patient-derived xenografts (PDXs) revealed a key role for RANK in postmenopausal women with estrogen receptor negative (ER-) breast cancer.'
Ciscar et al @EmboMolMed
https://www.embopress.org/doi/full/10.15252/emmm.202216715