Thiago Carvalho @cyrilpedia@social.cleverlibre.org

My new Clinical Pipeline column is out in Nature Medicine.
It's on JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.
#Immunology #drugdiscovery #drugdevelopment #alopecia

https://www.nature.com/articles/d41591-023-00065-z

I don't think everyone realizes how much #neuroscience #opendata is really downloaded and reused...

e.g. our dataset of responses to visual stimuli has 18,000 downloads; wholebrain #zebrafish neural activity from the Ahrens lab has 7,000 downloads; Nick Steinmetz's eight-probe Neuropixels data has 6,500 downloads. and there are many commonly used neuro datasets on websites that don't count downloads that must have thousands too!

post your data and they will come :) #openscience

One day we're going to have to stop trusting papers from people who have demonstrated their untrustworthiness.

https://www.nature.com/articles/d41586-023-02401-2

Senior Bioinformatician

MRC London Institute of Medical Sciences

We are seeking a skilled and motivated Senior Bioinformatician with significant experience in genomics and transcriptomics to join the Facility.

See the full job description on jobRxiv: https://jobrxiv.org/job/mrc-london-institute-of-medical-sciences-27778-senior-bioinformatician-2/?feed_id=52713

#ScienceJobs #hir...
https://jobrxiv.org/job/mrc-london-institute-of-medical-sciences-27778-senior-bioinformatician-2/?feed_id=52713

Now it's Global Boiling:

https://www.theguardian.com/science/2023/jul/27/scientists-july-world-hottest-month-record-climate-temperatures

#GlobalWarming #climatechange #climatecrisis #News #heatwave

@cyrilpedia honestly, speaking from a UK perspective, the idea that (obviously non-generic) drugs are marketed straight to patients utterly bemusing!

Is the idea genuinely that the half-informed patient sees it and then goes to their doctor asking about/for it?!

I guest-posted on @DNA 's Samuraipunk substack "Accidental Samurai: How I became, despite my best intentions, a cyber-biopunk novelist.

https://samuraipunk.substack.com/p/accidental-samurai

@cyrilpedia interesting. You can see how a signal came out in that population. My hunch is that it's time & dose dependent, but that doesn't massively help in autoimmune conditions in which treatment is long, spanning into years potentially.

Thank you.

Well, I'm on the #job market. I hold a master in Computational Social Science and am currently based in #Madrid, #Spain.

💻 I am proficient in #R and #SQL, and capable to work with #Python and #QGIS.

🗣️Spanish and English

If anyone has information on any jobs related to Data Analysis, Data Science, Research, etc. I would be very grateful if you could let me know!

#jobsearch

"Maps 1 & 4 The Conan Map (Brest, France, 16th Century)

This Renaissance print is a copy of a vellum drawn circa 1156 at the behest of Conan IV (“the Black”), Duke of Brittany, during a dynastic dispute with King Henry II of England, who was also Count of neighboring Anjou. As shown in the inset, the image’s purpose is solely to assert power and legitimacy. The multiple lines shown in the inset (the only remaining panel of a set of three) proclaim the conquest and rule of the corresponding regions by the Duke and his kinsmen in the House of Penthièvre."

#Art #Print #Printmaking #Etching #Handmade #Cartography#ArtGallery #Maps #artmastodon

https://madalenaparreira.com/SPAM

Upon their return, Black veterans encountered violence back in America. In 1946, an appalling incident occurred in Georgia, where a mob shot and killed 2 Black men and their wives, with no one brought to trial for the crime. In South Carolina, police subjected Army Sergeant Isaac Woodard to a brutal beating with night sticks after pulling him from a bus, leaving him permanently blind.

23/

#BlackMastodon #Histodons #History #BlackMastodon #BlackHistory #Military #StillWeRise #Truman #Missouri

#IDMastodon #Viralimmunology #CaseReport @Cureus A Case of #postCOVID19 Rhino-Cerebral #mucormycosis in an Immunocompromised Patient . It is theorized that the infection caused by severe acute #SarsCoV2 might impact the cluster of differentiation CD4+ & cytotoxic T cells (CD8+), which play a significant role in the pathological progression of #COVID19.