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"Patients with Crohn’s disease have increased levels of anti-S. cerevisiae antibodies (which detect mannan, a common component of the fungal cell wall. Measurement of these antibodies can be used to distinguish between Crohn’s disease & ulcerative colitis"

nature.com/articles/s41575-023

Closing libraries is how you burn books without lighting a match.

There's something delicious about a brilliant, Nobel-prize-winning scientist being wrong.

I'm reading Richard Feynman's (throroughly enjoyable) "Six Easy Pieces" (amzn.to/45ie510). In a fine bit of epistemic trespassing, he decides to sum up biology. This is how he starts...

'For example, loss of function of the microglial gene Trem2 renders microglia dysfunctional and causes an early-onset neurodegenerative syndrome, and Trem2 variants are among the strongest genetic risk factors for AD. Thus, restoring microglial function represents a rational therapeutic approach. Here, we show that systemic hematopoietic cell transplantation followed by enhancement of microglia replacement restores microglial function in a Trem2 mutant mouse model of AD.'

cell.com/cell-stem-cell/fullte

Tricky Dick strikes again:

'Nixon’s advisers reportedly coined the phrase “pulling a Nixon” for the oenophile president’s predilection for pouring official guests vin ordinaire while surreptitiously drinking First Growth Claret.’

ft.com/content/b31ce09e-6909-4

The dangers posed by nuclear weapons are great and growing.

Editors of health journals call on health professionals to support efforts to eliminate nuclear weapons
bmj.com/content/382/bmj.p1682 @kamranabbasi @parveenazamali @mja_editor @kbibbinsdomingo @ippnw

Very interesting thoughts happening: "In vivo hematopoietic stem cell modification by mRNA delivery"
science.org/doi/10.1126/scienc

“Mosquitoes are evolving as humans have pushed them to adapt. Climate change is adding to the health crisis in India.”

@aliyabashir reports on how climate change is changing dengue fever
bmj.com/content/382/bmj.p1690

I will die on this hill:
We will not fix our democracy until we start doing criminal prosecutions of the wealthy again. Not just weakly using DPAs and fines
and prosecutions of corporations.

Musk and the hospital execs in the news today must face threats of *jail*.

No fine will ever break a billionaire— they just pay out some funds and move on. But criminal charges can take down their lifestyle and hold them truly accountable.
#musk #doj #trump #indictment

The rank corruption of Clarence Thomas continues to be exposed, one sleazy item at a time.

How are we learning about this? Not from law enforcement or others who have subpoena power (e.g. Congress), but by journalists.

Latest example, from the NY Times. nytimes.com/2023/08/05/us/clar

Public health in action! Though it shouldn't need to be if the water was clean enough!

#Ecoli #sewage #water #triathlon #diarrhoea #diarrhea #ukpolitics #publichealth #microbiology #infectiousdiseases #medicine

Investigation after 57 swimmers fall sick and get diarrhoea at Sunderland world triathlon championship race

> Athletes competing on stretch of UK coastline where reduced water quality at centre of dispute over sewage discharges

theguardian.com/environment/20

Going out on a limb here to speculate that these problems are not limited to the Geoscience community:

"Admission to doctoral study is a crucial step in the academic pipeline, but discriminatory procedures can disproportionately impact students from ethnic minority backgrounds. We show how these policies contribute to inequity in the geosciences and propose strategies for change."

nature.com/articles/s41561-023

'Imitating each hormone individually can lead to weight loss, Tschöp says. But together, they work synergistically to keep each other in check. GIP activation suppresses GLP-1 activation’s side effects, and both of these hormone copycats stimulate insulin, preventing glucagon from raising blood glucose too high.'

nature.com/articles/d41586-023

“Tellingly, though, the lawsuit didn’t allege theft or its civil-law cousin — “conversion,” in lawyers’ language. It alleged only unjust enrichment. That’s probably because under current law and precedent, proving that Thermo Fisher Scientific or Johns Hopkins took anything from Lacks illegally would have been difficult or impossible..”

nytimes.com/2023/08/04/opinion

"La derecha tiene en EE UU, no sé si en España sucede lo mismo, una maquinaria. Facebook ha dado a esa maquinaria una difusión que no habría tenido de otra manera”.

elpais.com/tecnologia/2023-08-

'Este espetáculo ignominioso é tanto mais chocante quando decorre durante uma maioria de um partido de matriz laica e social-democrata e sob os auspícios delirantes de um presidente que passa a vida a pregar sobre transparência, escrutínio democrático e uma correta alocação dos recursos, mas, miguelisticamente, esquece tudo isso estando em causa a sua fação religiosa.'

dn.pt/opiniao/-o-tao-velho-por

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