Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Whole Genome Duplication and Gene Evolution in the Hyperdiverse Venomous Gastropods https://doi.org/10.1093/molbev/msad171 #science #evolution #biology #genome #evolgen_paper

📢 Nominations now open for the Lifetime Achievement Award! 🏆

Whose conceptual advances, impactful publications, outreach & education efforts, mentorship & training, service to the community, or diversity & inclusion work has contributed to the field & community?

Nominate them for this award! We also welcome self nominations!

The initial nomination form requires just two 250-word statements, with longer letters of support requested later.

Deadline: September 30

http://www.evolutionsociety.org/society-awards-and-prizes/lifetime-achievement-award.html

New study suggests people who tested negative for Covid-19 can still develop long Covid

https://www.statnews.com/2023/08/23/long-covid-diagnosis-negative-test/?utm_medium=social&utm_source=mastodon&utm_campaign=mastodon_organic

"The Art of Anatomy in Medieval Europe
Taylor McCall Reaktion (2023)

Art historian Taylor McCall dismantles the common belief that Renaissance figures such as Leonardo da Vinci and Andreas Vesalius founded the field of human anatomy. Assisted by vivid medieval illustrations, she argues that the earliest anatomical images date from the twelfth century, in monasteries and then early universities. Her scholarly book, the first in this field, aims to show that such imagery is “its own visual language”, by exploring anatomy in religious contexts, medical teaching and practice, and the work of professional artists."

https://www.nature.com/articles/d41586-023-02634-1

'La campaña de vacunación frente a la covid comenzará en otoño junto con la de la gripe, enfocada a los colectivos más vulnerables a la enfermedad. Pero todavía no está claro qué fármacos se utilizarán.'

https://elpais.com/sociedad/2023-08-23/como-sera-la-campana-de-vacunacion-de-covid-tras-el-verano-sanidad-estudia-que-farmaco-inyectara.html

"An influential expert panel has given its highest recommendation to an expanded menu of H.I.V. prevention strategies for adults and adolescents, a move that will require private insurers to cover the drugs without a co-pay or deductible under the Affordable Care Act."
#HIV #publichealth

https://www.nytimes.com/2023/08/22/health/hiv-prep-truvada-descovy.html?action=click&module=Well&pgtype=Homepage&section=Health

Links 8/23/23 https://mikethemadbiologist.com/2023/08/23/links-8-23-23/

'Meanwhile, scientific interest in vagus nerve stimulation is exploding, with studies investigating it as a potential treatment for everything from obesity to depression, arthritis and Covid-related fatigue. So, what exactly is the vagus nerve, and is all this hype warranted?'

https://www.theguardian.com/society/2023/aug/23/the-key-to-depression-obesity-alcoholism-and-more-why-the-vagus-nerve-is-so-exciting-to-scientists

'The elucidation of the lipid metabolic pathways that promote innate immune memory contributes to our understanding of trained immunity and may help identify therapeutic tools and targets for the modulation of innate immune responses.'
#immunology #InnateImmunity #Preprint

https://www.biorxiv.org/content/10.1101/2023.08.22.554295v1

"On Tuesday, an international team announced in the journal Cell that they had identified a potential new antibiotic lurking unnoticed in the sandy soil of North Carolina. The compound, called clovibactin, employs an unusual method of killing bacteria that makes it tough for targets to develop resistance. While clinical trials in humans are several years away, the finding is a glimmer of hope in an increasingly drug-resistant world."

#microbiology #antibioticresistance #antibiotics #drugdevelopment

https://www.ft.com/content/a8d62524-3f3f-4d61-a27f-a689a13f9232

Interesting work from the labs of David Baker and Carolyn Bertozzi showing EndoTag proteins, designed to bind extracellular face of receptors, target complexes for degradation.

Designed Endocytosis-Triggering Proteins mediate Targeted Degradation and amplify signaling
https://www.biorxiv.org/content/10.1101/2023.08.19.553321v1

#CellBiology #MembraneTrafficking

Turtle Shells Record Nuclear History https://www.scientificamerican.com/article/turtle-shells-record-nuclear-history/

'Together, these results demonstrate that host cGAS–STING senses T. cruzi infection, enhancing parasite growth at the site of entry, and contributes to acute-phase parasite restriction in the heart, a major site of tissue damage in chronic T. cruzi infection.'
#immunology #InnateImmunity #HostPathogen

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2300373/265860/cGAS-STING-Pathway-Activation-during-Trypanosoma?redirectedFrom=fulltext

'Sharing your setbacks can seem counter-intuitive, especially when these events stir up feelings of shame and inadequacy. But that’s why Geszvain shares her experiences and encourages her students to do the same.'

https://www.nature.com/articles/d41586-023-02603-8

'Coinciding with rising awareness about the risks of R.S.V., there are finally tools available to prevent severe infections in both infants and older adults.'
#Infection #immunology #vaccines #MonoclonalAntibody #RSV

https://www.nytimes.com/article/rsv-vaccine.html

AHR is also highly active in endothelial cells lining BV in 🫁 .
🫁 barrier between the body & the air outside is only made up of 2 layers, one of endothelial cells and one of epithelial cells to allow oxygen to enter & the barrier also has to be kept strong against pollution or 🦠 &bacteria.
https://www.crick.ac.uk/news/2023-08-16_research-finds-that-molecules-in-vegetables-can-help-to-ease-lung-infection