'Using several high-throughput sequencing approaches, we show that the H/ACA complex is recruited to actively transcribed genes genome-wide, where it performs mRNA pseudouridylation. Moreover, we demonstrate that this modification reduces the rate of mRNA translation and that loss of dyskerin-mediated pseudouridylation results in global elevation of protein synthesis.'
#MolecularBiology #mRNA
This is Switzerland taking Russia's side. This is Switzerland effectively arming aggressor Russia by stopping defender Ukraine from arming itself.
The Swiss government will not allow almost 100 Leopard I tanks stored in Italy to be sold to Ukraine.
George Takei on the Ugly Danger of Scapegoating: “There are few things more terrifying than demagogic populism, sharpened dangerously into authoritarian rule, with minorities left at the mercy of those now in charge of writing and enforcing the laws.”
https://www.thedailybeast.com/george-takei-on-the-ugly-danger-of-scapegoating?ref=home
'Why would blood group make any difference to SARS-CoV-2? Several new studies offer possible explanations. One from Stowell and colleagues, recently published in Blood, suggests that having type A blood makes SARS-CoV-2 “stickier” to host cells.'
'Resistant pathogens killed 1.26mn people in 2019, according to an analysis published in the medical journal The Lancet. “All of modern medicine is upheld by our ability to control infectious disease. If we can’t control infection, we can’t administer chemotherapy, do invasive surgery, and preterm birth becomes really, really challenging and risky”
https://www.ft.com/content/e9aeb9a3-a93c-439b-ab81-a7c71266d992
More cancer screenings sounds like good news. But can the NHS cope with them?
'But scientists who study viral transmission see another lesson in the pandemic school closures: Had the indoor air been cleaner and safer, they may have been avoidable. The coronavirus is an airborne threat, and the incidence of Covid was about 40 percent lower in schools that improved air quality, one study found.'
#Covid #Covid19 #PublicHealth
In Scotland, hundreds of hospital wards have been forced to close due to COVID outbreaks in the first seven months of this year. They ended testing last year and ended their mask mandate earlier this year. Pretending COVID is over equals constant disruption. https://www.heraldscotland.com/news/23746393.hundreds-hospital-wards-closed-due-covid-outbreaks/?ref=twtrec
Nematoceran fly —aka mosquito or midge-like— sipping nectar, its head and paintbrush antennae (the size alone labels it as male: their purpose is to locate females) bobbing up and down as if listening to heavy metal. Wish I recorded a video.
Faintest idea what species this is, I have not.
'To add insult to injury, the bot is being trained on pirated copies of my books. Now, really! How cheap is that? Would it kill these companies to shell out the measly price of 33 books? They intend to make a lot of money off the entities they have reared and fattened on my words, so they could at least buy me a coffee.'
https://www.theatlantic.com/books/archive/2023/08/ai-chatbot-training-books-margaret-atwood/675151/
@cyrilpedia
This 👇 is the key passage to me. Sadly no one wins from the #fragmentation that's come from the decline of #twitter / #X
#Threads #Bluesky #Bastodon #academicchatter #academia @academicchatter
Details
"Although there is widespread agreement that practicing reproducible research is a good idea, there is equally widespread variation in both how to practice reproducible research and what practicing reproducible research constitutes"
'In patients with heart failure with preserved ejection fraction and obesity, treatment with semaglutide (2.4 mg) led to larger reductions in symptoms and physical limitations, greater improvements in exercise function, and greater weight loss than placebo'
https://www.nejm.org/doi/full/10.1056/NEJMoa2306963?query=featured_homeo
'No se sabe; sobre lo que sí hay certeza es que, en sus últimas palabras desde La Moneda, se despidió del pueblo, de la madre obrera, de los profesionales, de la juventud, del trabajador, del campesino, del intelectual, pero omitió cualquier mención a esa Unidad Popular que fue creada por sus propias manos, así como a sus partidos, dirigentes y militantes.'
https://elpais.com/ideas/2023-08-27/salvador-allende-50-anos-de-inmortalidad.html
'Two more US Department of State documents relating to Augusto Pinochet’s coup d’état in Chile have been declassified, revealing how President Richard Nixon was briefed on the impending military takeover.'
Live long & prosper. And host pathogens.
"The white-footed deermouse Peromyscus leucopus, a long-lived rodent, is a key reservoir for agents of several zoonoses, including Lyme disease. While persistently infected, this deermouse is without apparent disability or diminished fitness"
#immunology #InfectiousDisease #HostPathogen #ResistanceTolerance
“AR Gov Sanders suggests course on Black history spreads ‘hate’ against U.S.”
I’ve said this before and I’ll say it again: Some white people were enslavers. Other white people were abolitionists. If you think teaching that accurate history “spreads hate”—then you’ll have to first explain why you associate more with enslavers than with abolitionists?🤔
https://www.msnbc.com/the-reidout/reidout-blog/sarah-huckabee-sanders-ap-african-american-history-hate-comments-rcna100657
'Concerns about the decline of X as a source of reliable information extends beyond the scientific and academic communities. During the apparent coup attempt in Russia in June, journalists noticed its relative uselessness at helping them find real-time, breaking information from the ground and sifting fact from fakery, due in part to Musk’s trashing of its account verification system.'
Fun fact for people who think #COVID19 is “just the flu”:
According to the CDC, in the four weeks of July 2023 (the weeks of 7/1, 7/8, 7/15/ and 7/22, which was during what many consider a “low” or “safe” period):
1,990 people died of COVID
86 people died of flu
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com