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'Picking out proteins and sending them into the vicious shredder that is the proteasome is a completely new mode of action for drugs, and there are many examples of it leading to effects that you just don't see (can't see!) with traditional small-molecule inhibitors. But as these things get further and further into development, and as more and more effort has been poured into them in both industry and academia, details inevitably emerge that make the whole picture more complicated.'

science.org/content/blog-post/

@cyrilpedia Our lab recently catalogued our biggest energy slurpers. The -80C freezers easily came out on top, 10s of kWh/day according to the data sheet. Computation came as a surprising second, and we don't have any clue what the terribly insulated 1960s building costs to keep moderately warm in winter.

My previous institute ran a "get a new -80 freezer for free if you scrap two old ones" challenge for a while. Apparently the new freezers paid for themselves within a couple years.

'Implementing a series of sustainable practices in health research could help the field to reduce its hefty carbon footprint, according to a report commissioned by health-research funder Wellcome.'

nature.com/articles/d41586-023

'Here, once again, my personal landscape shifted and the possibility of a career in science seemed beyond my reach. I struggled to sleep at nights. I even tried distracting myself with daily 7 mile runs, every pounding step the question echoing: What do you do when you don’t know what to do?'

thenode.biologists.com/crackin

“But the analysis discovered one major change: The incomes of the rich grew much faster in countries where tax rates were lowered. Instead of trickling down to the middle class, tax cuts for the rich may not accomplish much more than help the rich keep more of their riches and exacerbate income inequality, the research indicates.”

#tax #taxes #inequality #rich #middleclass

cbsnews.com/news/tax-cuts-rich

'From their first appearance in the U.S., the syringe tides were a ready-made tabloid sensation, and a shocking visualization of the perils of a throwaway society. In the years that followed, major efforts would be taken to reduce Americans’ solid-waste production and protect its shores. But the steel-and-plastic flotsam raised a more specific warning, too, about the increasing and deliberate wastefulness of the American health-care system. That concern went unheeded at the time.'

theatlantic.com/technology/arc

Postdoc and Postgrad Positions in Computational Biology, Human Genetics, an

Yale University School of Medicine

Postdoc and postgrad positions open in Dr. Renato Polimanti’s group at the Yale University School of Medicine

See the full job description on jobRxiv: jobrxiv.org/job/yale-universit...
jobrxiv.org/job/yale-universit

Now that the Republican former Lieutenant Governor of Georgia admits that Trump is running "a Ponzi scheme of lies" with the "moral compass of an axe murderer," I wonder what it would take for my #GOP-voting relatives to admit how profoundly they fucked up? theguardian.com/us-news/2023/a

A large share (estimates range from 25% to 40%) of #COVID19 infections are nosocomial (occurring in medical facilities.) And, people who are infected in hospitals are MUCH more likely to suffer complications and have a lower rate of recovery.

Why aren't masks required in hospitals all the time? Why wait for a surge that hospitals helped create? The modern Hippocratic Oath states, “I will prevent disease whenever I can, for prevention is preferable to cure.”

scrippsnews.com/stories/hospit

FYI: Clarence Thomas and Samuel Alito — both of whom accepted luxury vacations from billionaires — could rule on an upcoming Supreme Court case that would ban a federal wealth tax.

If they don’t recuse themselves, why would we expect Americans to ever trust SCOTUS again?

'Politicians have become particularly skittish about what ought to be common-sense steps to protect basic public health. The Pasteur Act, for instance, would address the antibiotic resistance crisis that threatens our entire system of medical care, but it’s been stalled in Congress for years. Funding for federal pandemic preparedness programs comes up for reauthorization in September, but its passage is in doubt.'

nytimes.com/2023/08/28/opinion

'As climate-related disasters grow in frequency and intensity, major home insurers in some locations are concluding that no premium—or at least no premium that customers are willing to pay and state regulators are likely to permit—will cover the potential losses.'

theatlantic.com/ideas/archive/

'Acontece que um espaço de cinema (e, no caso do Monumental, de salas de cinema e de um teatro, depois da demolição do edifício original dos anos 50) só pode ser destruído — a lei define a situação com o preciosismo da “desafectação do espaço da actividade cinematográfica” — com autorização do ministro da Cultura.

Esperamos que o senhor ministro da Cultura esteja à altura dessa responsabilidade.'

publico.pt/2023/08/29/culturai

Not good.

'Data from Uganda showed the emergence of partial resistance to artemisinins in multiple geographic locations, with increasing prevalence and regional spread over time.'

nejm.org/doi/full/10.1056/NEJM

'Nicola Sacco and Bartolomeo Vanzetti, Italian immigrants, had been arrested, tried, convicted, and would be executed for a crime they didn’t commit. My grandfather had immigrated to the United States in 1907, the same year they did—paesani—and in the 1910s he and Vanzetti had worked together in Clinton, Massachusetts, building a railroad and living, with all the other immigrant workers, in railroad sleeping cars in a part of town known as Little Italy.'

nybooks.com/online/2023/08/27/

'Loan them out, get them back. Head to the library. Get some more. Pass them on, every book a gift, every library an inheritance, a scroll, unfurling, like a newborn’s tiny hand, opening, the child of a whole family, each of its ancestors.'

nybooks.com/online/2023/08/27/

'The “pooled fund” is designed to reduce the high costs of developing new treatments. It would do so partly by increasing the number of experimental drugs being tested, raising the chances that some will succeed. It would also reduce the risks of unsuccessful new products by bringing in capital from non-profit backers who do not seek financial returns.'

ft.com/content/2f939fbd-06ee-4

'Contrary to maternal antibodies, maternal microchimeric cells (MMc) show a high longevity, as they can persist in the offspring until adulthood. Recent evidence highlights that MMc leukocytes promote neonatal immunity against early-life infections in mice and humans.'

Yuzen et al @emboreports

embopress.org/doi/full/10.1525

Lots of clever ideas here for new air conditioning technologies, including ways to separate cooling from dehumidifying scientificamerican.com/article

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