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Biochemical analysis revealed that Lft1 and Laa2 bind to Laa1 via the same interface. Following a suggestion by a colleague to try Alphafold2, we found that the two likely bind via a common mechanism, although the Lft1 interface is a little larger—something confirmed by our biochemical results.

#Alphafold #AlphaFold2 #ProteinPrediction

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So, what does this new Lft1-Laa1 complex do? Frankly, it’s still a mystery. However, if you dig into the literature, especially proteomics and high-throughput data, it looks like HEATR5 proteins are involved in non-AP1 pathways in other organisms,
endocytosis in worms, nature.com/articles/ncb1627
AP2, pubmed.ncbi.nlm.nih.gov/158113
AP-AP3 in human cells, doi.org/10.1101/2021.11.19.469
endocytosis in plants
doi.org/10.1101/2022.03.17.484

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Today's must read.👇

"For a long time, democracy in the U.S. meant democracy only for white men. Constitutional sheriffs are making this argument again in their quest to keep the country white, one county at a time." democracydocket.com/opinion/sh

“My only advice to our large and diverse community is to do everything we can to make science and peer review transparent.”

Author, Subhash Kulkarni, tells us about their experience of publishing a Reviewed Preprint.
elifesciences.org/inside-elife

Finally, we know that HEATR5B in humans is mutated in a rare human disorder that causes pontocerebellar hypoplasia. Whether this is due to effects on AP1 or other pathways is unclear.

nature.com/articles/s41431-021

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New anti-CD40L

'AT-1501, as a monotherapy and in conjunction with other immunosuppressive agents to prevent graft rejection in nonhuman primates. Encouragingly, AT-1501 promoted survival and function of islet and kidney allografts in cynomolgus and rhesus macaques, respectively, without evidence of thromboembolism.'

science.org/doi/10.1126/scitra

For the last two summers, some of Europe’s most notorious neo-Nazi networks met for a recreational retreat, with concerts, combat fighting and hot tubs, at undisclosed resorts in the Finnish wilderness. Teemu Nieminen and @ColborneMichael found the location. bellingcat.com/news/2023/08/31

📢New #BehindthePaper story on the Node

Tirtha Das Banerjee and Antόnia Monteiro tell the story behind their paper exploring the expression and function of Wnt signaling pathway members in setting up butterfly wing patterns 🦋

thenode.biologists.com/pattern

“Justice #ClarenceThomas disclosed Thursday that Republican megadonor #HarlanCrow paid for private jet trips for Thomas in 2022 to attend a speech in Texas and a vacation at Crow's luxurious New York estate, according to newly released financial disclosure forms.” #SCOTUS

apple.news/AspJPYdTMQsaYlwKsSY

'She is one of the 4.2 million South Africans living with diabetes, according to 2021 estimates from the International Diabetes Federation. The prevalence has more than doubled between 2011 and 2021 and is by far the highest in sub-Saharan Africa: by 2045, more than 7.4 million South Africans could be diabetic.'

theguardian.com/global-develop

#throwbackthursday Here is an old image I took many moons ago.
#confocal #microscopy image of #MouseFibroblast cell with multiple nuclei. False coloured and inverted to be on a white background. Blue microtubules, green nuclei

Are you ready to dive into a whirlwind of knowledge, fun, and free lunch? Our #OpenScience Workshop is just around the corner!

📅 When: Oct 16th - 20th

🕒 Where: Bordeaux Neurocampus

💲 How much: FREE!

💸 Travel grants: Not in Bordeaux? No problemo, we have a few travel grants available!

✅ ECTs: Yup! This week can be validated as training hours!

👥 Who: Anyone interested in improving their research practices!

Link: bordeaux-neurocampus.github.io

📢 Help us spread this event by sharing this post!

Why haven't #hospitals' & #doctors' associations spoken out about the #Medicare #drug negotiations?

Because if they supported price-fixing, they'd have to support the regulation of their own rates, which they've protested for years.

(they're also making money off of expensive drugs 👀)

@STAT's Bob Herman with the incisive take:

statnews.com/2023/08/31/pharma

#CMS #pharma #bigpharma #health #healthcare #medicine

Hi there!

I am a biologist working in the University of Antioquia, in Medellín, Colombia. I am mostly involved in #ComputationalBiology and #Bioinformatics, but I enjoy and work in other subjects too:

- Molecular Biology
- Genetics
- Dynamical systems (ODEs)
- Systems Biology
- Microbiology

I believe in #OpenScience and I could say that #Linux and free software changed my life.

Currently I am promoting the field of Computational Biology in Colombia: biologia-computacional.github.

#introduction

FYI

'That said, the Food and Drug Administration has extended the expiration dates for certain brands of tests. You can check a test by finding the lot number (typically found right by the expiration date) and cross-referencing it at this F.D.A. website.'

nytimes.com/2023/08/29/well/li

'With hospitalisation rates low but rising, experts said Covid-19 cannot yet be treated as a seasonal virus like flu. The US Centers for Disease Control and Prevention warned last week that a new sub-variant, BA. 2.86, may be more able to cause infection in people who have previously had Covid-19 or been vaccinated against it, and urged the vulnerable to wear masks in public places.'

ft.com/content/5ec35a44-eadd-4

'New tracking tools are also helping us to scale up from spatiotemporal analyses of behavioral components to a systems-level view of the whole. The systems approach focuses on structure–function relationships, moving from cause-and-effect thinking to synergistic thinking, by emphasizing interactions, linkages, and integrated phenotypes'

journals.plos.org/plosbiology/

'Es un tipo muy duro. Meticuloso. Comprometido. Y ese espíritu se refleja en sus proyectos, como Amazônia, al que pertenecen las imágenes de estas páginas: travesías por la selva amazónica a lo largo de varios años para retratar la tragedia ecológica y humana de la destrucción del pulmón del planeta.'

elpais.com/eps/2023-08-30/seba

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