'In an ideal world, the authors would engage collaboratively with journals and those who have raised concerns on determining how to adjust the scientific record to account for these problems, and journals would post updates quickly. This rarely happens, and that needs to change.'
https://www.latimes.com/opinion/story/2023-08-31/stanford-marc-tessier-lavigne-science-retractions
"A PSP é a responsável pelos sistemas. Isto significa que será a PSP a ver e a guardar as imagens e que fará isso sem nenhuma supervisão. Tem tudo para correr bem. Numa situação em que direitos fundamentais das pessoas estão em causa, ninguém tomou a liberdade de pensar na necessidade de uma supervisão."
https://www.publico.pt/2023/09/01/opiniao/opiniao/dermos-big-brother-esquina-2061835
ER stress induces #caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with #herpes simplex #virus type 2
#HSV type 2 infection promotes #neuronal #celldeath and #inflammatory responses via #ERstress-dependent #gasdermin E activation.
Søren Paludan and colleagues
2 x fully funded four year PhD positions in Aquatic Ecology here at SLU AQUA - Swedish University of Agricultural Sciences (SLU). Both are broadly related to the effects of algal toxins
https://www.slu.se/en/about-slu/work-at-slu/jobs-vacancies/?rmpage=job&rmjob=8890&rmlang=UK
https://www.slu.se/en/about-slu/work-at-slu/jobs-vacancies/?rmpage=job&rmjob=8881&rmlang=UK
How do new #TasteBud cells connect with a taste ganglion #neuron? @ZacharyWhiddon1 @Krimmlab &co use in vivo 2-photon microscopy to observe motility & branching of taste axon arbors, revealing remarkable structural plasticity in taste buds #PLOSBiology https://plos.io/3PlIRAH
The best time to join a union was yesterday, the second best time is today.
https://www.timeshighereducation.com/opinion/bullying-feature-uk-research-universities-not-bug
"As a research community, we must crack the myth of a single career trajectory from masters to PhDs to post-docs to tenured faculty. That’s merely one path in the maze of the scientific landscape"
My friend Scott Wesley Long and his team at Houston Methodist today identified the first case of BA.2.86 in Texas, only the 4th so far in the US! It’s spreading slowly (other lineages still dominant) but it’s spreading. https://www.linkedin.com/posts/swesleylong_houston-is-in-a-summer-covid-wave-what-to-activity-7103071664933933056-KS4a?utm_source=share&utm_medium=member_ios
Population collapse almost wiped out human ancestors, say scientists
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#EvolutionMEWS #BiologyMEWS #ScienceMEWS #GeneticsMEWS #WorldNewsMEWS #MEWS
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Genomics analysis indicates that at least 800,000 years ago breeding individuals sank to as few as 1,300Early human ancestors came close to eradication in a severe evolutionary bottleneck between 800,000 and 900,000 year...
'From their first appearance in the U.S., the syringe tides were a ready-made tabloid sensation, and a shocking visualization of the perils of a throwaway society. In the years that followed, major efforts would be taken to reduce Americans’ solid-waste production and protect its shores. But the steel-and-plastic flotsam raised a more specific warning, too, about the increasing and deliberate wastefulness of the American health-care system. That concern went unheeded at the time.'
Ten new faculty positions at the The Okinawa Institute of Science and Technology (with ten more to open by 2026).
Application deadline: October 31, 2023.
Tardigrades have survived every mass extinction on Earth since they evolved about a 1/2 billion years ago.There are ~1,300 known species.
And millions of years from now, they won’t even notice we’re gone.
https://www.smithsonianmag.com/smart-news/tardigrades-turn-out-not-be-dna-thieves-180964236/ #nature Image: Eye of Science/Science Photo Library
Biochemical analysis revealed that Lft1 and Laa2 bind to Laa1 via the same interface. Following a suggestion by a colleague to try Alphafold2, we found that the two likely bind via a common mechanism, although the Lft1 interface is a little larger—something confirmed by our biochemical results.
So, what does this new Lft1-Laa1 complex do? Frankly, it’s still a mystery. However, if you dig into the literature, especially proteomics and high-throughput data, it looks like HEATR5 proteins are involved in non-AP1 pathways in other organisms,
endocytosis in worms, https://nature.com/articles/ncb1627
AP2, https://pubmed.ncbi.nlm.nih.gov/15811338/
AP-AP3 in human cells, https://doi.org/10.1101/2021.11.19.469212
endocytosis in plants
https://doi.org/10.1101/2022.03.17.484738
Today's must read.👇
"For a long time, democracy in the U.S. meant democracy only for white men. Constitutional sheriffs are making this argument again in their quest to keep the country white, one county at a time." https://www.democracydocket.com/opinion/sheriffs-who-back-the-great-replacement-as-the-new-big-lie/
“My only advice to our large and diverse community is to do everything we can to make science and peer review transparent.”
Author, Subhash Kulkarni, tells us about their experience of publishing a Reviewed Preprint.
https://elifesciences.org/inside-elife/96648f88?utm_source=mastodon&utm_medium=social&utm_campaign=organic
X wants permission to start collecting your biometric data and employment history
https://www.theverge.com/2023/8/31/23853618/x-privacy-policy-update-biometrics-job-history
Finally, we know that HEATR5B in humans is mutated in a rare human disorder that causes pontocerebellar hypoplasia. Whether this is due to effects on AP1 or other pathways is unclear.
New anti-CD40L
'AT-1501, as a monotherapy and in conjunction with other immunosuppressive agents to prevent graft rejection in nonhuman primates. Encouragingly, AT-1501 promoted survival and function of islet and kidney allografts in cynomolgus and rhesus macaques, respectively, without evidence of thromboembolism.'
For the last two summers, some of Europe’s most notorious neo-Nazi networks met for a recreational retreat, with concerts, combat fighting and hot tubs, at undisclosed resorts in the Finnish wilderness. Teemu Nieminen and @ColborneMichael found the location. https://www.bellingcat.com/news/2023/08/31/saunas-and-swastikas-finlands-summertime-neo-nazi-meet-up/?utm_source=mstdn
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com