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I've been comparing social media platforms for effictiveness at getting out a PhD advert. Comparing reposts not a like-for-like as TwiX and LinkedIn both use likes to populate your feed. On this basis, LinkedIn clear winner, X clear loser. LinkedIn stripped out links though, grr!

New blogpost, inspired, as usual, by irritation.
deevybee.blogspot.com/2023/09/
I sometimes think the research literature is so mired by questionable research practices that there is really no hope.
#integrity #p-hacking #PublicationBias #QRPs #neurodevelopment

@SteveRuss

Spare you the click:
3 post-doc vacancies to join the Steventon Lab at the Dept. of Genetics in Cambridge, UK, on:
1. peripheral nerve regeneration;
2. zebrafish imaging;
3. bioengineering.
gen.cam.ac.uk/join-us/current-

#PhDJobs #FediHire #jobs #academia #neuroscience #zebrafish

"Man lives consciously for himself, but is an unconscious instrument in the attainment of the historic, universal, aims of humanity."
War and Peace

Lev Nikolayevich Tolstoy was born #OTD in 1828. He is best known for his two longest works, War and Peace & Anna Karenina, which are commonly regarded as among the finest novels ever written. War and Peace in particular seems virtually to define this form for many readers and critics.

Leo Tolstoy at PG:
gutenberg.org/ebooks/author/13

#books #literature

Cool new work lead by John H Wen:

One-shot entorhinal maps enable flexible navigation in novel environments
biorxiv.org/content/10.1101/20

#neuroscience #research

"The importance of conformational ensembles to IDR function, coupled to the inherent sensitivity of IDRs to their physicochemical environment, gives rise to the possibility of IDRs acting as molecular sensors of their surrounding physicochemical environment"

sciencedirect.com/science/arti

'In some cases, GWAS results have highlighted previously underappreciated mechanisms contributing to pathogenesis. For example, genetic variants associated with AD risk are enriched in genes and enhancers (regions in the genome that control gene expression) acting in myeloid cells, likely microglia. This indicated the important role of innate immune cells in AD. Therefore, the enrichment of risk variants in specific biological pathways can deepen our mechanistic understanding of neurodegenerative diseases and may even point to new therapeutic targets.'

science.org/doi/10.1126/scienc

'Desde muy joven, Saura mostró su interés por diferentes disciplinas artísticas. La fotografía, la pintura y la música formaban parte del calor familiar. Pero la pasión por el cine nació en la calle, cuando en el Madrid pobre y apaleado de la posguerra el pequeño se escapaba a las sesiones de los cines de barrio cercanos a su casa familiar de la avenida de Menéndez Pelayo para ver una y otra vez la versión de los años treinta de El prisionero de Zenda.'

elpais.com/eps/2023-09-06/las-

You go through a lot of interns...

'Until recently, the only reliable way to determine the age of a polar bear has been to extract a premolar and inspect its growth rings. “No researcher wants to do it,” Dr. Woodruff said'

nytimes.com/2023/08/10/science

"Multivalent antigen display is strongly associated with higher antibody titers and therefore likely has a direct influence on the interaction with B cells. Yet, mechanistic studies in vivo of how antigen valency affects the B cell response are very limited."

cell.com/immunity/fulltext/S10

"New York is home to six species of Chiroptera that overwinter in the state; the animals cope with the cold by hibernating, usually underground, in caves or abandoned mine shafts. Dangling from the ceiling by their toes, the bats descend into a state of torpor so complete it resembles suspended animation. Because they don’t move, hibernating bats are easy to census."

nybooks.com/articles/2023/09/2

Closing a loop: The entire modern field of regulatory T cells emerged from the ashes of the suppressor T cell field because of experiments showing destruction of the reproductive system following neonatal thymectomy.

"We found that Treg depletion induces severe autoimmune orchitis and epididymitis, manifested by an exacerbated immune cell infiltration [CD4 T cells, monocytes, and mononuclear phagocytes (MPs)] and the development of antisperm antibodies (ASA)."

pnas.org/doi/10.1073/pnas.2306

In case you missed it: Matthias Tschöp told me the story of the science behind the popular new class of anti-obesity drugs.

Listen to "Obesity is a Brain Disease" 🎧 👇

open.spotify.com/show/5tiWyc9z

'Under the terms of the deal, the United Kingdom will pay in €2.6 billion per year to be an ‘associate’ member of Horizon Europe for the rest of the scheme’s current term, set to end in 2027.'

nature.com/articles/d41586-023

Postdoctoral Associate

University of Pittsburgh

Come join us for an exciting funded opportunity to explore the cell biology of #bipolar disorder and push the boundaries of imaging!

See the full job description on jobRxiv: jobrxiv.org/job/university-of-

#ScienceJobs #hiring #research #cryo-EM #dopamine #teamtomo #neuroscience #mitoc...
jobrxiv.org/job/university-of-

'We explored CDN-mediated immunity in 14 Drosophila species covering 50 million years of evolution and found that 2′3′-cGAMP and 3′2′-cGAMP failed to control infection by Drosophila C virus in D. serrata and two other species.'

cell.com/immunity/fulltext/S10

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