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"We established the Stroke Preclinical Assessment Network (SPAN) to design and implement a randomized, controlled, blinded, multi-laboratory trial for the rigorous assessment of candidate stroke treatments combined with intravascular thrombectomy."

science.org/doi/10.1126/scitra

It now looks like, per another brilliant report by ProPublica, that our dear Justice Clarence Thomas also participated in Koch Network donor events. Is there no end to his corruption and influence peddling? Don’t answer that, I know the answer.

'Para Luís Menezes Leitão existem os superiores interesses dos senhorios e pouco mais. Nem uma palavra acerca das circunstâncias em que se encontram milhares de inquilinos e outros tantos que nem conseguem arrendar casa.'

publico.pt/2023/09/22/opiniao/

'One lesson is that when it comes to technology, we’re lazy. We reach for the nearest familiar tool without thinking about whether it’s the right one for the job, or even thinking clearly about what the job is. Are we trying to think through a problem? Get a discussion going? Show people that worth-a-thousand-words picture? We skip that vital contemplative step and load up a slide template instead. Because everyone can use PowerPoint, everyone does.'

ft.com/content/728cb9a0-aa62-4

V2 of my preprint with PhD student Kim Verity is now online: biorxiv.org/content/10.1101/20

tldr: If you want to assess the shape (e.g. balance, diversity) of a rooted tree then generally you're better off using our new indices than Sackin's index, phylogenetic entropy, etc.

The article is long mainly because we provide lots of examples. I plan soon to write a shorter #mathonco blog post explaining why these indices are better than prior approaches. Meanwhile, here's a poster.

Checkpoint inhibitors beyond cancer: targets for restoring CD8 T cell function in people living with HIV.

"Our results demonstrated a marked and significant increase in TIGIT CD8+ T-cells, particularly within the central memory compartment, not ameliorated by long-term ART."

elifesciences.org/articles/837

Out @PLOSBiology! Inhibitory signals from turning neurons gate the worm's response to mechanosensory stimuli! Beautiful work by Sandeep Kumar and co-authors Anuj Sharma, Andrew Tran & Mochi Liu plos.io/455hWOh

This “thought-provoking” paper exploits new #CryoET tools to examine the state of chromatin in situ, finding that nucleosomes in baker’s yeast cells are different from those in test tubes. elifesciences.org/articles/876

'Their personalities were fundamentally unalike, in ways that could scratch like sandpaper. The Irish critic George Moore, who hung out with them in Paris, described them thus: “Manet loud, declaratory, and eager for medals and decorations; Degas sharp, deep, more profound, scornfully sarcastic.”

nytimes.com/2023/09/21/arts/de

Marine Le Pen should stand trial over alleged misuse of EU funds, say prosecutors

Request comes after a seven-year investigation into far-right leader’s party

theguardian.com/world/2023/sep

On this day in 1863: Alexandre Yersin born, co-discovered bacteria that causes the plague (Yersina pestis) & diphtheria toxin #ThisDayInBiotech

'El teniente coronel brasileño Mauro Cid, que durante cuatro años fue secretario particular de Jair Bolsonaro, ha declarado a la policía que, tras la derrota electoral, el aún presidente se reunió con la cúpula militar para consultarles sobre un posible golpe de Estado'

elpais.com/internacional/2023-

Michael Faraday was born #OTD in 1791. English scientist who contributed to the study of electromagnetism and electrochemistry. His main discoveries include the principles underlying electromagnetic induction, diamagnetism and electrolysis. As a chemist, he discovered benzene, investigated the clathrate hydrate of chlorine, invented an early form of the Bunsen burner and the system of oxidation numbers. via @wikipedia

Michael Faraday at PG:
gutenberg.org/ebooks/author/55

#books #science #physics

'Because the scRNA-seq dataset had been obtained using CITE-seq, a method that keeps track of cell-surface markers by using oligonucleotide-tagged antibodies, we were able to identify surface markers for human exTreg cells. We found that CD56 and CD16 (normally expressed by natural killer cells) identify human exTreg cells.'

nature.com/articles/s41590-023

I talked to Inside Science on BBC Radio Four about our upcoming ocean-based carbon dioxide removal (#CDR) experiment in San Francisco Bay here. I also said other things about CDR and MRV. Starts at 21:45.

bbc.co.uk/programmes/m001qmpq

"(...) in 2022, the College Board boasts, roughly 1.2 million students took more than four million A.P. exams in public high schools throughout the country. And when I teach a first-year writing course, or an introductory course in the English major, I inevitably spend the first few weeks undoing the damage the A.P. system does to how students understand both writing and the study of literature."

newrepublic.com/article/173547

Chromosome-Scale Genome Assembly of the Solitary Parasitoid Wasp Microplitis manilae Ashmead, 1904 (Braconidae: Microgastrinae) doi.org/10.1093/gbe/evad144 #science #evolution #biology #genome #evolgen_paper

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