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#LongCovid 

'Anecdotally, from the clinics we know that some people come back and say, “I feel better” or “I feel I improved.” If you dig a little bit deeper, they did not get back to their baseline; they adjusted their baseline ... Recovery, unfortunately — for fatigue and dysautonomia and all that — is actually quite rare'

#LongCovid

statnews.com/2023/09/20/do-lon

'El teniente coronel brasileño Mauro Cid, que durante cuatro años fue secretario particular de Jair Bolsonaro, ha declarado a la policía que, tras la derrota electoral, el aún presidente se reunió con la cúpula militar para consultarles sobre un posible golpe de Estado'

elpais.com/internacional/2023-

'Their personalities were fundamentally unalike, in ways that could scratch like sandpaper. The Irish critic George Moore, who hung out with them in Paris, described them thus: “Manet loud, declaratory, and eager for medals and decorations; Degas sharp, deep, more profound, scornfully sarcastic.”

nytimes.com/2023/09/21/arts/de

'Because the scRNA-seq dataset had been obtained using CITE-seq, a method that keeps track of cell-surface markers by using oligonucleotide-tagged antibodies, we were able to identify surface markers for human exTreg cells. We found that CD56 and CD16 (normally expressed by natural killer cells) identify human exTreg cells.'

nature.com/articles/s41590-023

Gut microbial carbohydrate metabolism contributes to insulin resistance nature.com/articles/s41586-023

Interesting differences in SCFAs, too, with implications for obsession (of some) with increasing presence of these in the human gut.

Brazil supreme court rules in favor of Indigenous land rights in historic win

Court voted against agribusiness-backed attempt to prevent communities claiming land they did not physically occupy in 1988

theguardian.com/world/2023/sep

Corrupt public officials like #ClarenceThomas do double damage to the citizens they're entrusted to serve.

Not only do they subvert the functioning of democracy by allowing uberwealthy elites to tip the scales of justice in their own favor, they also destroy public confidence in democracy itself, opening the door for more corruption, and ultimately, authoritarianism.

For shame. A functional society would not stand for this.

propublica.org/article/clarenc

Much like why there's no bus route on Park Ave, "sustainability" is all platitudes from the rich and never action in their neighborhood.

'Much of the controversy arises from differing views on the defining characteristics of eukaryotes. We argue that eukaryotes should be defined phylogenetically, and that doing so clarifies where competing hypotheses of eukaryogenesis agree and how we may test among aspects of disagreement.'

cell.com/current-biology/fullt

"We established the Stroke Preclinical Assessment Network (SPAN) to design and implement a randomized, controlled, blinded, multi-laboratory trial for the rigorous assessment of candidate stroke treatments combined with intravascular thrombectomy."

science.org/doi/10.1126/scitra

It now looks like, per another brilliant report by ProPublica, that our dear Justice Clarence Thomas also participated in Koch Network donor events. Is there no end to his corruption and influence peddling? Don’t answer that, I know the answer.

'Para Luís Menezes Leitão existem os superiores interesses dos senhorios e pouco mais. Nem uma palavra acerca das circunstâncias em que se encontram milhares de inquilinos e outros tantos que nem conseguem arrendar casa.'

publico.pt/2023/09/22/opiniao/

'One lesson is that when it comes to technology, we’re lazy. We reach for the nearest familiar tool without thinking about whether it’s the right one for the job, or even thinking clearly about what the job is. Are we trying to think through a problem? Get a discussion going? Show people that worth-a-thousand-words picture? We skip that vital contemplative step and load up a slide template instead. Because everyone can use PowerPoint, everyone does.'

ft.com/content/728cb9a0-aa62-4

V2 of my preprint with PhD student Kim Verity is now online: biorxiv.org/content/10.1101/20

tldr: If you want to assess the shape (e.g. balance, diversity) of a rooted tree then generally you're better off using our new indices than Sackin's index, phylogenetic entropy, etc.

The article is long mainly because we provide lots of examples. I plan soon to write a shorter #mathonco blog post explaining why these indices are better than prior approaches. Meanwhile, here's a poster.

Checkpoint inhibitors beyond cancer: targets for restoring CD8 T cell function in people living with HIV.

"Our results demonstrated a marked and significant increase in TIGIT CD8+ T-cells, particularly within the central memory compartment, not ameliorated by long-term ART."

elifesciences.org/articles/837

Out @PLOSBiology! Inhibitory signals from turning neurons gate the worm's response to mechanosensory stimuli! Beautiful work by Sandeep Kumar and co-authors Anuj Sharma, Andrew Tran & Mochi Liu plos.io/455hWOh

This “thought-provoking” paper exploits new #CryoET tools to examine the state of chromatin in situ, finding that nucleosomes in baker’s yeast cells are different from those in test tubes. elifesciences.org/articles/876

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