Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
We privatised the water companies into an artificial market. We failed to regulate or control that artificial market. So instead of investing in infrastructure, the private companies sold out to foreign investors, who borrowed debt to give to execs and shareholders. And now they want the customers to pay for the infrastructure upgrades. To deal with the water shortages and sewage spills.
It's a long con.
Thiago Carvalho
boosted
Postdoc Position in Single-Molecule Biophysics
Albert Einstein College of Medicine
The Laboratory of Prof. Arne Gennerich at the Albert Einstein College of Medicine invites applications for a Postdoc position.
See the full job description on jobRxiv: https://jobrxiv.org/job/albert-einstein-college-of-medicine-27778-postdoc-position-in-single-molecule-biophysics/?...
https://jobrxiv.org/job/albert-einstein-college-of-medicine-27778-postdoc-position-in-single-molecule-biophysics/?feed_id=60403
'Por exemplo, no Verão de 2021, diziam: “Primeiro, vão vacinar-nos, depois vão tirar-nos as armas e as bíblias.” Tornou-se uma espécie de plataforma importante do Partido Republicano. Durante esse Verão, quando a variante Delta atingiu a Europa e os Estados Unidos, as pessoas morreram nos Estados Unidos porque se recusaram a aceitar as vacinas, apesar de estas estarem disponíveis gratuitamente.'
Thiago Carvalho
boosted
Oh yeah, maybe we should pay some attention to this. #clarencethomas #scotus #KochBros #corruption #propublica
'Los notables avances contra el cáncer logrados por la medicina en las dos últimas décadas tienen para el oncólogo Aleix Prat (Barcelona, 44 años) un lastre que limita su potencial: el escaso diagnóstico molecular que se realiza de los tumores, algo que impide identificar a los pacientes que más podrían beneficiarse de las terapias innovadoras. “Necesitamos tratar a 10 enfermos para que apenas se beneficien dos o tres. El resto paga un alto precio en toxicidad y, además, el coste económico para el sistema es insostenible”
"Defining that threat is not simple. The challenge is to do for infectious diseases what other researchers can now do for droughts or hurricanes: “attribute” events to climate change. “The very cutting edge right now is actually trying to start doing attribution … to say, for each degree of temperature change, how many more cases do we get?” says Erin Mordecai, an infectious disease ecologist at Stanford University."
"Psychologists in particular wanted a statistical skeleton key to unlock true experimental insights. It was an unrealistic burden to place on statistics, but the longing for a mathematical seal of approval burned hot."
https://www.sciencenews.org/article/statistical-significance-p-value-null-hypothesis-origins
Thiago Carvalho
boosted
The Republican billionaire donors using anti-trans talking points to buy the bigoted evangelical voting block are about to lose their minds. Yay.
https://www.nytimes.com/2023/01/25/us/politics/transgender-laws-republicans.html
Thiago Carvalho
boosted
Classic Radiohead Songs Re-Imagined as a Sci-Fi Book, Pulp Fiction Magazine & Other Nostalgic Artifacts
Thiago Carvalho
boosted
It's a bumper news month for next generation Covid vaccines!
My @PLOS Update 11 is online now:
- Govt support for 2 vaxes, in Japan & US - $$$ hundreds of millions
- Encouraging early phase 2 trial results for immunocompromised people on blood cancer treatment
- Another Covid nasal spray vax into clinical trial (USA)
- First large study on nasal Covid vax to prevent infection underway in China
Plus more clinical & preclinical results:
'However, as Keller would often emphasize later on, this approach did not mean that McClintock was pursuing science in a distinctively feminine way, either. Instead, as Horning notes, Keller’s aim, stated in “Reflections on Gender and Science,” was the “reclamation, from within science, of science as a human instead of a masculine project.”
https://news.mit.edu/2023/professor-emerita-evelyn-fox-keller-dies-0925
"Further, when CART cells were treated with IL-4, they developed signs of exhaustion, but when CART cells were treated with an IL-4 monoclonal antibody, they showed improved antitumor efficacy and reduced signs of exhaustion in preclinical models."
Thiago Carvalho
boosted
Aardvark in progress by @hunchbacksociety
https://madalenaparreira.com/Hunchbacksociety
#Ceramics #Handmade #Art #stoneware #artgallery #artmastodon
"After realising that many notable women working in science, technology, engineering and maths (Stem) and others from minority backgrounds did not have Wikipedia pages, though they were deserving of them, she decided to start them herself, one every day. Each one takes “a few hours” to write, she says. It’s a task, she confesses, that she somehow completes while simultaneously watching real estate shows on Netflix in the evening. To date, she has contributed more than 2,000 entries."
Thiago Carvalho
boosted
At this point, I fear we might only be weeks away from Musk tweeting "you know, Hitler had a point..."
Elon Musk Attacks German Support for Migrants, Boosts Far-Right Extremists
https://www.businessinsider.com/elon-musk-immigration-migrants-germany-far-right-extremism-twitter-x-2023-9
Thiago Carvalho
boosted
Merck filed a biologics license application for sotatercept in pulmonary arterial hypertension & now the FDA has granted it priority review.
https://www.merck.com/news/merck-receives-priority-review-from-fda-for-new-biologics-license-application-for-sotatercept-an-activin-signaling-inhibitor-to-treat-adults-with-pulmonary-arterial-hypertension-pah/
I wrote about the drug last fall for Nature Medicine:
"BMPR-II regulates apoptosis and has anti-proliferative effects on pulmonary smooth muscle and endothelial cells. Sotatercept should assist BMPR-II in its tug-of-war with another TGF-beta family member, ActRIIA (which promotes proliferation), by selectively trapping activin pathway ligands. Unlike existing therapies that provide symptomatic management, sotatercept has the potential to be a curative treatment for pulmonary arterial hypertension by modifying the underlying causes of the disease."
Thiago Carvalho
boosted
"Salmonella Typhimurium mutants for spermidine transport and synthesis cannot mount an antioxidative response, resulting in high intracellular ROS levels. These mutants are also compromised in their ability to be phagocytosed by macrophages"
#Microbiology #Preprint #Salmonella #MucosalImmunology #immunology
https://www.biorxiv.org/content/10.1101/2023.09.29.560257v1?med=mas
Thiago Carvalho
boosted
“It became the custom in such cases to give credit solely to the one who actually made the experiment work, even if others may have also conceived the idea. It was the drosophilists’ golden rule. Ideas that were engendered in the group’s informal shoptalk were treated as communal resource and not as personal property.”
(Robert E. Kohler, Lords of the Fly)
#Books #Bookshelf #ScienceHistory #SciComm #Drosophila #bookstodon
Thiago Carvalho
boosted
Thiago Carvalho
boosted
Tomorrow morning the Noble Prize in Physiology or Medicine will be announced.
The new Ground Truths makes the case for transformer model #AI as having made an essential contribution for the recent Lasker "American Nobel" Award and throughout life science
https://erictopol.substack.com/p/a-new-precedentai-gets-the-american
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
