Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
"A neuroscientist whose studies undergird an experimental Alzheimer’s drug was “reckless” in his failure to keep or provide original data, an offense that “amounts to significant research misconduct,” an investigation by his university has concluded."
https://www.nytimes.com/2023/10/14/health/alzheimers-drug-research-simufilam.html
Thiago Carvalho
boosted
Science in Portugal never recovered from the Troika. According this piece in Expresso (a credible newspaper) public investment has now regressed to 1991 levels.
"Os números são inequívocos: se em 2010 a despesa pública em investigação e desenvolvimento chegou a 0,54% do PIB, em 2023 não ultrapassa os 0,32% — um valor inferior ao registado em 1991 e que representa menos de metade da média atual da OCDE."
Thiago Carvalho
boosted
"Over the past week, Jews living in Germany’s capital Berlin have been waking up to a chilling sight — Stars of David sprayed on the front doors of their apartment blocks."
https://www.ft.com/content/ed744535-d04f-4519-ac27-2be077cac912
"What’s most important is that these models ensure equitable access to these treatments for any eligible patient. The tens of thousands of people with sickle cell should all have the same opportunity as Carter: to wake up one day and feel what it’s like to not be in pain. Equitable access is also what matters for the future of the technological revolution brewing in medicine. After all, what good are miracle cures if only the few can get them?"
"Altogether, these data demonstrate that MMRd in these models is not sufficient to increase immunogenicity or sensitivity of tumors to ICB, alone or in combination with chemotherapy, in stark contrast to previous reports in cell-line transplant models"
Thiago Carvalho
boosted
Since 2010, the 10 executives who served as CEO of Ford, GM, and Stellantis raked in more than $1 billion in compensation.
Don't tell me these companies can't afford to give auto workers better wages and benefits.
Thiago Carvalho
boosted
A wonderful turnaround since it was less than a decade ago that most European countries got rid of their night trains
From the bad place (come on @miguelgf ...), Miguel Godinho & Claudio Sunkel.
Thiago Carvalho
boosted
Online Now: PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00755-4?rss=yes&utm_source=dlvr.it&utm_medium=mastodon
Thiago Carvalho
boosted
What do students at the University of Rijeka, Croatia, think about open access and open science practices?
Dejana Golenko, Evgenia Arh, and Ksenija Bazdaric offer theoretical and practical reflections on the importance of scientists' information literacy skills and their experiences with #OpenAccess when implementing #OpenScience policies.
Read it for free: https://doi.org/10.3897/ese.2023.e106656 #InformationLiteracy #EuropeanScienceEditing #SciencePolicy
"Importantly, being an author is not only about credit but also about accountability. Typically, an author will be accountable for the quality and integrity of their own contribution, but also for the work as a whole by ensuring that questions arising post-publication are investigated thoroughly and that materials and data remain available."
#ResearchAssessment #ResearchIntegrity #ScientificPublication
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002364
Thiago Carvalho
boosted
Everyone gets imposter syndrome at some point. It's not fun and feels terrible but it'll pass #MentalHealth #SelfCare #ImposterSyndrome
Thiago Carvalho
boosted
The #UMontana is cancelling more than 5,000 #journals from #Elsevier, #TaylorAndFrancis, and #Wiley, forced by "rising journal… #prices and a stagnant #budget… The library has seen a $700,000 reduction in money received since fiscal year 2020."
https://nbcmontana.com/news/local/mansfield-library-at-um-set-to-cut-largest-e-journal-packages
#Academia #Cancellations #Libraries #Publishers #Universities
@academicchatter
Until I worked on this piece, I had no idea how out of control blood pressure still is for most people. Estimates are that only one fifth of those with high blood pressure manage it effectively. New RNA drugs that may only require dosing two to four times a year could really help, but at what cost? My latest Clinical Pipeline column.
"We found that pDCs express the IgA-specific Fc receptor, FcαR , and there was a striking ability of IgA1 autoantibodies to synergize with IgG in RNA-containing ICs to generate robust pDC IFNα responses."
#Preprint #Immunology #Lupus
Thiago Carvalho
boosted
Review in Issue 20:
The plant non-coding transcriptome
Highlight: How centrosomes & PIDD1 help natural killer cells clear polyploid cells
Inflammation caused by exosome-secreted mtDNA
Pioneer activity distinguishes SOX2 binding sites
Cover: Wolfgang Zachariae et al
Thiago Carvalho
boosted
The Ants Who Build Barns for their Livestock:
Everyone knows ants are excellent little architects building homes of leaves, silk, or paper (an "ant carton" similar to material made by wasps) & of course, homes in soil or tree cavities.
But, some ants also build homes for their livestock. Little brown ants who live in English Oaks build barns out of moss to house their favorite aphids & accompany their heard to & from the pasture each night. (the pasture is in the tree)
"Questions about whether Covid leaked from a Chinese laboratory have cast a chill over American virus research, drying up funding for scientists who collect or alter dangerous pathogens and intensifying a debate over those practices."
https://www.nytimes.com/2023/10/16/science/lab-leak-virus-research-gain-of-function.html
Thiago Carvalho
boosted
"Regulators have taken notice after a study sparked fresh doubts over the usefulness of a Covid drug (molnupiravir) made by US pharma group Merck, raising questions about the costly procurement of antivirals during the peak of the pandemic."
https://www.ft.com/content/c4b3f696-327f-4a3a-8594-885599ae6f8d
Thiago Carvalho
boosted
"That lack of surprise is the scar tissue that Black Americans have built up — the knowledge that the worst is always possible. The mind and spirit continually make space for it, forever hoping, but preparing contingencies for hope’s inevitable betrayal."
https://www.nytimes.com/2023/10/11/opinion/rsv-vaccine-race-ethics.html
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
