Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"Ultimately, however, Factor VIII killed many of those who infused it in the 1970s and 1980s. For decades, British officials and ministers claimed that the contaminated blood scandal was a tragedy no one could have prevented: when haemophiliacs began to be infected, hepatitis C hadn’t even been named, and HIV/Aids was entirely unknown; new protocols were introduced once the dangers became clear. According to Margaret Thatcher, ‘all patients received the best treatment available in light of the medical knowledge at the time.’ These claims were not true."
https://www.lrb.co.uk/the-paper/v45/n22/florence-sutcliffe-braithwaite/we-ve-messed-up-boys
"Factor VIII concentrate was developed later in the decade. Production involved pooling many batches of donated blood, then fractionating it. The Factor VIII was freeze-dried and packed into bottles. Haemophiliacs could get it out of the fridge themselves, mix it and inject it to stop bleeds. It was a miracle treatment: in 1962 the median life expectancy for severe haemophiliacs in Britain was 37; by 1980 it was practically normal."
https://www.lrb.co.uk/the-paper/v45/n22/florence-sutcliffe-braithwaite/we-ve-messed-up-boys
Thiago Carvalho
boosted
Wegovy cuts risk of heart attacks in milestone cardiovascular trial
Thiago Carvalho
boosted
My colleagues recently published a paper on #apoptosis in the #drosophila dorsal #epidermis. They have shown that two factors can predict #cell #extrusion and apoptosis. Cell size sensed by #hippo and relative cell size (compared to neighbors) sensed by #notch
https://www.cell.com/current-biology/fulltext/S0960-9822(23)01298-8
Thiago Carvalho
boosted
Did you know that ErrantScience has an impact factor of 3 top hats, we hope one day to get it up to 6 imaginary frogs
Thiago Carvalho
boosted
Weekend #Plankton #Factoid 🦐🦠
A bit of a strange one. Rotifers can increase #microplastics particles by their feeding mechanism. #Rotifers feed by a ciliated corona, which looks like a wheel spinning (thus "wheeled animacules") into a pharynx with calcified trophi. When plastic particles are eaten, they are broken up into smaller bits. Rotifers are very common in #freshwater where most microplastics are deposited, potentially making the situation worse. #zooplankton
https://www.theguardian.com/environment/2023/nov/09/microplastic-eating-plankton-worsening-crisis-oceans-plastic-pollution
Thiago Carvalho
boosted
"Anita fue derivada, junto a otros 52 niños, al Hospital Universitario Psiquiátrico de Heidelberg. Estaba dirigido por Carl Schneider, uno de los más reputados psiquiatras de su tiempo. Dirigía un estudio que buscaba establecer las diferencias entre discapacidades del desarrollo congénitas y las adquiridas en los primeros meses y años de vida. Schneider era también el responsable de Aktion T4, el programa estatal de eutanasia. Tras ser estudiada, Anita fue asesinada y, como ella, otros 10.000 niños con alguna discapacidad."
Thiago Carvalho
boosted
"Not everyone who develops a psychiatric disorder later in life will also develop dementia, but given how often the two types of conditions occur together, Dr. Garcia-Ptacek advised that doctors order cognitive testing for older adults with new psychiatric symptoms, as a precaution."
https://www.nytimes.com/2023/11/08/well/mind/mental-illness-depression-dementia.html
Tools
"Here we present a new optogenetic CRISPR tool, BLU-VIPR, that diverges from prevailing split-Cas design strategies and instead focuses on optogenetic regulation of gRNA production."
Thiago Carvalho
boosted
According to Leibniz's notebooks, a critical breakthrough occurred #OTD in 1675, when he employed integral calculus for the 1st time to find the area under the graph of a function y = f(x). He introduced several notations used to this day, for instance the integral sign ∫ (∫f(x)dx)
representing an elongated S, from the Latin word summa, & the d used for differentials (dy/(dx), from the Latin word differentia. Leibniz did not publish anything about his calculus until 1684.
Thiago Carvalho
boosted
Researcher resignations from UKRI mount amid Israel–Hamas row
Thiago Carvalho
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PhD Position Optical bio*materials: composition, function, development
University of Salzburg, Chemistry and physics of materials
Do you want to earn a PhD exploring composition and development of photonic structures at U Salzburg, and learn how colours are made and seen?
See the full job description on jobRxiv: https://j...
https://jobrxiv.org/job/university-of-salzburg-chemistry-and-physics-of-materials-27778-phd-position-optical-biomaterials-composition-function-development/?feed_id=65032
Thiago Carvalho
boosted
"So the foundations of the entire Cassava Alzheimer's program are shaky. And as you'll see from this, that's not the end of it. Thirty-four papers by Cassava-associated scientists have come under scrutiny for research irregularities, and this led to a petition filing to the FDA asking that the company be investigated and their clinical trials halted."
Thiago Carvalho
boosted
"Although my letter precedes the furore ignited by Michelle Donelan’s missive to UKRI raising her concerns about tweets by members of Research England’s Equality, Diversity and Inclusion (EDI) Advisory Group, it touches on a related issue: the use and interpretation of evidence in political discourse on matters that are central to research and higher education."
https://occamstypewriter.org/scurry/2023/11/10/open-letter-secretary-of-state-edi/
Thiago Carvalho
boosted
"At least two million low-income children have lost health insurance since the end of a federal policy that guaranteed coverage through Medicaid earlier in the Covid-19 pandemic, according to newanalyses by researchers at the Georgetown Center for Children and Families and KFF, a health policy research organization."
https://www.nytimes.com/2023/11/09/health/medicaid-children-lost-coverage.html
Thiago Carvalho
boosted
(settler colonialism🧵)
The French laws that applied in Algeria discriminated against Indigenous nations and privileged the white Europeans rights over those of the majority Indigenous nations. In fact, different laws applied to Muslims in Algeria, whom for example were not allowed to vote, whereas white French people were allowed to.
Thiago Carvalho
boosted
(Settler colonialism 🧵)
5M indigenous Algerians were killed and crimes including torture, murder, rape, displacement, nuclear tests, land theft, and denial of the most basic rights were committed.
Many Algerian cities saw their names changed to be “Francized”. E.g. the name of the capital of Algeria, Algiers (in Arabic Al-Jazaïr) was changed into La Pointe-Pescade.
The main objective of settler colonialism is to totally erase the culture of indigenous’ people and destroy their legacy.
Thiago Carvalho
boosted
An example of settler colonialism can be found in the History of Algeria. Between 1830 and 1962, Algeria was considered a “French Department.”
Algeria was annexed and made officially a part of France in 1848. The French’s aim was to make Algeria a part of France by erasing the Indigenous’ rights and displacing them from their lands. Atrocious crimes were committed by French colonial authorities in Algeria throughout the 132 years of colonization.
'In an ingenious study published this summer, US researchers showed that within a few months of the launch of ChatGPT, copywriters and graphic designers on major online freelancing platforms saw a significant drop in the number of jobs they got, and even steeper declines in earnings.'
https://www.ft.com/content/b2928076-5c52-43e9-8872-08fda2aa2fcf
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
