Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Does anyone remember Sideshow, by William Shawcross? It’s a book that should be read again, and no time better than now.

https://electricliterature.com/my-year-in-re-reading-after-40-sideshow-by-william-shawcross/

You want to estimate FST for a polyploid? or a partial selfer? or some species with a weird reproductive mode? You want population specific FST as well as global FST? You have population sizes and migration estimates and want to predict FST? Check our latest paper with Bruce Weir:
https://tinyurl.com/3av4w7wu

"In this brief review, we present and summarize the data describing how newly described enhancers located within the large V gene portion of Igκ and Igh loci work as a higher-order mechanism for the regulation of the Ab repertoire formation by regulating chromatin interactions and epigenetic milieu, which in turn alter the 3D chromatin topology of the loci."
#immunology

https://journals.aai.org/jimmunol/article/211/11/1613/266443/Enhancers-within-the-Ig-V-Gene-Region-Orchestrate

"In 1921, nearly 30 per cent of 19-year-old Swiss conscripts had a goitre. In the cantons of Luzern and Obwalden, one in four men were exempt from military service as a result of goitres so large they struggled to breathe. For every man with a goitre, three women suffered from the condition"

https://www.lrb.co.uk/the-paper/v45/n23/jonah-goodman/a-national-evil

I'm looking forward to attending the ISSCR Vienna 'Elucidating Principles of Development with Stem Cells' symposium next week, on behalf of @Dev_journal @the_node and @Co_Biologists

We've put together a subject collection to accompany the meeting: In vitro models of development

https://journals.biologists.com/dev/collection/10030/In-vitro-models-of-development

Online Now: Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00921-8?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Behold LEGO Reenactments of Famous Psychology Experiments, as Imagined by Artificial Intelligence

https://www.openculture.com/2023/11/behold-lego-reenactments-of-famous-psychology-experiments-as-imagined-by-artificial-intelligence.html

'He told me he had started writing the song for a prospective musical version of Nosferatu years before, but never finished it. Around the time we were recording, Meat Loaf had lost his voice, and after it was a hit he always used to say: “Dang. That song should have been mine!”

https://www.theguardian.com/culture/2023/nov/27/bonnie-tyler-total-eclipse-of-the-heart-nosferatu-musical

"I'm not particularly impressed with Large Language Models as they apply to natural human languages - "plausible sentence generators" is the phrase that I've seen that sums up my beliefs about them. But for things that are less complex than natural language, these techniques have more real-world uses. Coding is one, naturally, because programming languages are smaller and more orderly than human ones. The language of protein sequences is another example"

https://www.science.org/content/blog-post/ai-hypotheses

@IanSudbery @copdeb @cyclotopie @cyrilpedia @academicchatter as I understand it, the NIH DP5 program is intended to transition early career scientists to independence without a postdoctoral period https://commonfund.nih.gov/earlyindependence

@cyclotopie @cyrilpedia @academicchatter

These graphs show the increased scarcity of #PI and other (possibly) stable #academic jobs. #PostDoc jobs cover a good part of the difference.

My colleague Joachim Wistuba is looking for a #PhDstudent for his fully funded
@dfg_public project on #KlinefelterSyndrome Deadline for application 27th December. More information on the position and how to apply here: https://jobs-sf.ukmuenster.de/job/UKM-Wissenschaftlicher-Mitarbeiter-%28gn%29/1011115001/
#PhDposition #Reproduction #Andrology

Harvard scholars call to eliminate orphan drug exemption in IRA to save Medicare more

https://endpts.com/harvard-scholars-call-to-eliminate-orphan-drug-exemption-in-ira-to-save-medicare-more

#pharma #pharmaindustry #pharmaceuticalindustry #orphandrugs

@cyrilpedia
Many interesting things in there about the increasing scarcity of stable #academic jobs …and also #gender inequalities.

@academicchatter