"In particular, our results show that AlphaFold predictions are not better representations of the contents of a crystal than the models deposited in the PDB, as the deposited models agree much more closely with experimental data where the predicted and deposited models differ."
"The test’s panel of 47 genes includes the BRCA1 and BRCA2 genes. Certain DNA changes in these genes increase the risk of hereditary forms of breast and ovarian cancer as well as several additional types of cancer."
https://www.cancer.gov/news-events/cancer-currents-blog/2023/fda-blood-test-hereditary-cancer-risk
"The fact that we saw attacks on the [police] cordon and the crime scene, these are clearly organized and orchestrated activities which need quite a lot of background organization… this is where we see the far-right's use of X," he said. "They were able to get a lot of people there very quickly to basically take control of that situation, direct it."
https://www.cbsnews.com/news/elon-musk-ireland-x-twitter-far-right-dublin-immigration/
“For years the EU has been trying to agree on a new system to respond to people moving or fleeing to Europe. The agreement now on the table would in many ways worsen existing legislation, and risks increasing suffering at European borders.”
Centrists are out of favour. But as the Netherlands is learning, the alternative is far worse | Arnon Grunberg
"After decades of steady environmental degradation in Xochimilco, Mexico wanted to know how many axolotls remained in the species’ last stronghold. Axolotls were of deep cultural importance, a feature of the region’s traditional diet and cosmology. And laboratory biologists all over the world, who for more than a century had used axolotls to study tissue regeneration, worried that their animals were becoming inbred, without a wild population from which to draw new bloodlines."
https://www.nytimes.com/2023/12/05/science/mexico-axolotl-biology.html
German Physicist And Philosopher Werner Heisenberg was born #OTD in 1901.
He was one of the main pioneers of the theory of quantum mechanics. He published his work in 1925 in a major breakthrough paper. In the subsequent series of papers with Max Born and Pascual Jordan, during the same year, his matrix formulation of quantum mechanics was substantially elaborated. He is known for the uncertainty principle, which he published in 1927. via @wikipedia
Advancing childhood cancer research through young investigator and advocate collaboration https://www.biorxiv.org/content/10.1101/2023.12.03.569769v1?med=mas
"The test’s panel of 47 genes includes the BRCA1 and BRCA2 genes. Certain DNA changes in these genes increase the risk of hereditary forms of breast and ovarian cancer as well as several additional types of cancer."
https://www.cancer.gov/news-events/cancer-currents-blog/2023/fda-blood-test-hereditary-cancer-risk
Pause to remind everyone that The Last Waltz is the greatest concert film ever made
"These crises are not about the planet going haywire. They are crises caused by failures to assign and enforce social responsibilities. And the wealthiest, most powerful and most capable societies that have ever existed on this planet are behaving as if they owe nothing for what they have gained at the expense of imperiling life on Earth."
https://www.nytimes.com/2023/12/04/opinion/rich-nations-climate-change-summit.html
UK immigration rules hit science just as it rejoins €100B Horizon program - https://www.theregister.com/2023/12/05/new_uk_immigration_rules_could/ further proof the tory morons haven't even begun to think this through...
"Here, we combine a stationary-phase screening method with deep learning-powered virtual screens and toxicity filtering to discover compounds with lethality against metabolically dormant bacteria and favorable toxicity profiles."
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00387-2
Nadine Randel and I wrote a dispatch on the recent miniature-wasp eye #connectome paper
Have a look:
https://www.sciencedirect.com/science/article/pii/S096098222301432X?dgcid=author
and here is the original paper on the Megaphragma eye by Chua and colleagues https://www.sciencedirect.com/science/article/pii/S096098222301237X
Interesting! L-fucose administration ameliorates the LPS-induced neuroinflammation in the Fut8+/− mice, suggesting that core fucosylation plays a vital role in anti-inflammation. L-Fuc as a potential drug against neuroinflammation?
"I wanted other people to know that if you fail the first time, it's not the end of the story."
https://nitter.cz/MaricutAkbik
won an ERC grant on her 2nd attempt. She explains her application strategy, plus use of ERC feedback. 👉
https://europa.eu/!Jhrk6D
https://nitter.cz/PolSciLeiden
https://nitter.cz/UniLeidenNews
https://nitter.cz/UniLeiden
🐦🔗: https://nitter.cz/ERC_Research/status/1732006990900281701#m
[2023-12-05 12:00 UTC]
rs - a multigenerational, ultra-wealthy drug-pusher dynasty - made billions while murdering hundreds of thousands of Americans by lying about the safety of #Oxycontin, the flagship product of their #PurduePharma drug company. *It's that they got away with it*.
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If you'd like an essay-formatted version of this thread to read or share, here's a link to it on pluralistic.net, my surveillance-free, ad-free, tracker-free blog:
https://pluralistic.net/2023/12/05/third-party-nonconsensual-releases/#au-recherche-du-pedos-perdue
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"Sellafield, Europe’s most hazardous nuclear site, has a worsening leak from a huge silo of radioactive waste that could pose a risk to the public, the Guardian can reveal."
“El caso es que esos hematófagos se extinguieron, y no sabemos por qué. Tal vez hubo más recursos para la hematofagia durante el cretácico temprano y luego los recursos disminuyeron o la competencia entre moscas hematófagas llevó a la extinción de los taxones menos adaptados”
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com