Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Christmas is coming early this year: we just dropped a new preprint!

"Beyond networks: explaining dynamics in the natural and social sciences."

https://osf.io/htc78

It's a broad criticism of network modeling in both the natural & social sciences & a study of where its shortcomings originate historically. 🧵

"However, the metrics generally used to evaluate protein structure prediction methods—including all of those used in CASP—focus on the overall accuracy of predicted structures, rather than on their utility in predicting ligand binding. This has left the large community of academic and industrial researchers who wish to use protein structures to design drugs and other ligands unsure of whether, when, and how to use the new structural models. Improvements in protein structure prediction are widely assumed to lead to better models of ligand-binding pockets and thus more accurate predictions of ligand binding (Beuming and Sherman, 2012; Bordogna et al., 2011; Erickson et al., 2004), but to what extent do these assumptions hold?"

https://elifesciences.org/articles/89386

The AMA says that repeated Covid infections greatly increase the risk of serious disease.

https://www.ama-assn.org/delivering-care/public-health/what-doctors-wish-patients-knew-about-covid-19-reinfection

#covid

Today we celebrate the birth of Sir Isaac Newton. Without his invention of calculus we would have no way to stop people who are bad at math from becoming engineers.

Today‘s temperature deviation, relative to the average 25 Dec during the period 1979-2000. Some areas are 18°C or more warmer than normal. Where “normal” is a time interval already affected by global warming.

We have "a rare chance to unbundle the #internet, to pull apart an existing system and rebuild it, piece by piece, in vastly better ways…if the next phase of how we congregate and communicate online is built for #humans and not advertisers.

What we’ll get instead is something much bigger: an entirely new infrastructure for our online lives that no company or platform controls."

https://www.theverge.com/23990974/social-media-2023-fediverse-mastodon-threads-activitypub

Researchers have discovered a way to build three-dimensional #organoids that resemble how skeletal muscle develops in the fetus. https://elifesciences.org/digests/87081/growing-skeletal-muscle?utm_source=mastodon&utm_medium=social&utm_campaign=organic

"Venice was a city of printers and readers. In his World of Aldus Manutius, Martin Lowry made a rough guess that, in 1500, Venetian presses produced twenty books per member of the city’s population. There were more printshops – and more booksellers, stationers, bookbinders – in Venice than anywhere else in Europe: twice as many editions were printed there than in Paris, its closest rival."

https://www.lrb.co.uk/the-paper/v45/n24/erin-maglaque/case-endings-and-calamity

The gift that keeps on giving:

"Os governos que saíram vencedores da II Guerra Mundial não deram de imediato atenção à ideia de criar uma carta de direitos para a Humanidade, interessados que estavam em discutir esferas de influência e em arquitetar a Carta das Nações Unidas de maneira a garantir os seus poderes de veto"

https://leitor.expresso.pt/semanario/semanario2669/html/revista-e/fisga/humanizar-os-direitos-humanos

#IDMastodon #Covid especially in vaccinated people the most common symptom is “sneezing”. So if you are sneezing on top of other ,known your symptoms & please get a RATest done- Don’t spoil 🎄 for everyone ,the advice to health professionals to return to work even if +ve RATest is simply reckless…

"When people have their biases and prejudices, yes, I am aware. My head is not in the sand. But my thing is, if I can't work with you, I will work around you. I was not about to be so discouraged that I'd walk away."

-- Annie J. Easley, NASA rocket scientist

"The Chinchorro culture began mummifying their dead in what is now southern Peru and northern Chile around 6000 bce, making South America’s earliest mummified bodies two thousand years older than those of Egypt."

https://www.lrb.co.uk/the-paper/v46/n01/erin-l.-thompson/even-the-eyelashes

'Measles cases continued to pop up here and there in the densely populated city in 1989 and 1990 — as is common with highly contagious infectious diseases. But measles never managed to get a firm grip on any particular neighborhood or community in that two-year period, in part because the vaccination rate among the overall population was reasonably good. That all changed once the illness made its way to the Faith Tabernacle school.'

https://www.phillymag.com/news/2021/03/20/philadelphia-measles-outbreak-1991/