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German physicist Wilhelm Röntgen died #OTD in 1923.

Nobel Prize in Physics won for his discovery of the remarkable rays subsequently named after him. In November 8, 1895, he found that, if the discharge tube is enclosed in a sealed, thick black carton to exclude all light, and if he worked in a dark room, a paper plate covered on one side with barium platinocyanide placed in the path of the rays became fluorescent even when it was as far as two metres from the discharge tube.

#physics #science

Fresh water flowing into the North Atlantic from melting glaciers is slowing down the Gulf Stream and other currents.

At some unknown point, it will hit a tipping point that will cause dire global #climate disruption, within a human lifetime.

Details of new research:
theconversation.com/atlantic-o #climatechange (via @TheConversationClimate)

"When the spreadsheet launched in 1979, it was a bewildering piece of software. People had no idea what they were looking at. A computer screen, filled with a grid of numbers? As Keith Houston explains in his new history of the pocket calculator, Empire of the Sum, they hadn’t realised that the rows and columns of a spreadsheet could be functional rather than decorative."

ft.com/content/c5f7909f-0bac-4

Excellent news: Surge in #endometriosis research after decades of underfunding could herald new era for women’s health - Nature Medicine

"Endometriosis affects 1 in 9 women and people who menstruate (which can include transgender men and non-binary people) — an estimated 190 million people globally. But like women’s health in general, the condition has been “disregarded, overlooked or particularly underfunded”, says Krina Zondervan"

nature.com/articles/s41591-024

"The world is continuously being transformed by science and technology (S&T), but to deliver equitable benefits to the public, scientists must be embedded in influential sectors of society—policy, diplomacy, journalism, law, business, education, and more. This means injecting PhD-level experts at every stage of research and development, from ideation, investigation, and investment to manufacture, deployment, regulation, and after-market evaluation."

science.org/doi/10.1126/scienc

Caveat emptor.

"If the reagents used for building libraries themselves (or those used for amplifying and confirming the clones following screening experiments) inadvertently contain cross-contaminated oligos, it will make the situation more complex.
We realized this possibility recently, as we observed some unexpected results (presence of unrelated sequences) when setting up a CRISPR library screening, which prompted us to investigate the issue further. Our systematic analyses of various reagents, research equipment, and multiple vendor-supplied oligos suggested that commercially synthesized oligos are the source for such cross-contaminants."

academic.oup.com/nar/advance-a

'Sage said both experts had “identified fundamental problems with the study design and methodology, unjustified or incorrect factual assumptions, material errors in the authors’ analysis of the data, and misleading presentations of the data that, in their opinions, demonstrate a lack of scientific rigor and invalidate the authors’ conclusions in whole or in part.”

nytimes.com/2024/02/09/health/

“Neste momento, os nossos equipamentos já perderam todas as garantias de assistência técnica e começam a ficar obsoletos. Não nos conseguimos manter na crista da onda, porque não vamos conseguir acompanhar”, confessa.'

publico.pt/2024/02/10/ciencia/

"Physicists in Europe this week unveiled a €16bn bid to build the world’s costliest instrument dedicated purely to scientific inquiry. They plan a giant particle accelerator in a 91km ring beneath the Swiss-French borderlands, in which subatomic particles will collide almost at the speed of light. The project has crystallised a debate about whether so many billions should be ploughed into fundamental research or spent on more practical issues, such as pandemic readiness and climate change."

ft.com/content/4b3d1a11-3fb7-4

This Sunday is #InterationalDayofWomanandGirlsinScience 🎉

We want to celebrate the fantastic #WomenInScience in our Editor team and thank them for their dedication to DMM!

From left to right:
Liz Patton #UniversityOfEdinburgh
Elaine Mardis #NationwideChildrensHospital
Sally Dunwoodie #VictorChangInstitute
Vivian Li @thecrick
Karen Liu #KingsCollegeLondon
Monica Justice #SickKidsToronoto
Sumana Sanyal #Dunn_School #uniofoxford

#WomeninSTEM

@WhatisBiotechnology 30 years ago today. A variant of this photograph of Howard Temin at his microscope has been hanging in my office for nearly that long. He was my thesis advisor at the University of Wisconsin-Madison in the mid-80s.

On this day in 1994 Howard Temin died, won 1975 Nobel Prize for work on tumour viruses #NobelPrize #ThisDayInBiotech

Caveat emptor.

"If the reagents used for building libraries themselves (or those used for amplifying and confirming the clones following screening experiments) inadvertently contain cross-contaminated oligos, it will make the situation more complex.
We realized this possibility recently, as we observed some unexpected results (presence of unrelated sequences) when setting up a CRISPR library screening, which prompted us to investigate the issue further. Our systematic analyses of various reagents, research equipment, and multiple vendor-supplied oligos suggested that commercially synthesized oligos are the source for such cross-contaminants."

academic.oup.com/nar/advance-a

Climate scientist Michael Mann wins defamation case against conservative writers

npr.org/2024/02/08/1230236546/

> Michael Mann, a prominent climate scientist, has been awarded more than $1 million in a case more than a decade in the making.

#science #climatechange

"The wrong Amazon is burning"
Sticker spotted in Anchorage, Alaska

Good tip:

"Uma forma de ver se a informação essencial num documento é legível é converter o documento num ficheiro .txt, desprovido de formatação complexa, e ver se a informação continua perceptível."

publico.pt/2024/02/08/tecnolog

“Rehab delivered live online improves health-related quality of life for people with long Covid at three and 12 months,” study co-author Gordon McGregor, professor of clinical exercise physiology and rehabilitation at University Hospitals Coventry & Warwickshire NHS Trust, said on a call with reporters. “This is the first high-quality study to confirm the benefit and also confirm a lack of harm from rehabilitation.”

statnews.com/2024/02/07/can-ex

"Any AI system is defined by its reliance on the use of data from the past to make decisions about the future.

"But the government signaled it is concerned that the technology’s use by insurers is allowing them to bend the future to their own benefit."

via @STAT
statnews.com/2024/02/07/govern

#AI #health #healthcare #medicine #MA #Medicare #insurance #healthinsurance

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