@Demosthenes That is a good question. I use web clients mostly -- Pinafore most of the time, running on a Browser window.

I do believe the excluded languages would be stored as a user preference, and the server would not send content to a client with that language.

But it's worth trying. I would also suggest looking for the Fedilab Lite version, at F-Droid.org, as it is lighter on resources use.

Good luck! :)