Oooh, I do like a lymphocyte adopting a novel metabolic configuration 😁🤓.

Resilient anti-tumour CD8 T with high Malic enzyme 1 expression.

ME1 makes glycolysis independent pyruvate and NADPH - the first for energy, the second supports GSH levels.

https://www.biorxiv.org/content/10.1101/2022.11.25.517988v1