Interesting new piece to the Srebp puzzle. Glutaminolysis released ammonia activated Srebp by disrupting scap-insig interaction. This effect of ammonia is blocked by 25-Hydroxycholesterol.
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The team led by Deliang Guo (@OhioState) shows that ammonia released from glutaminolysis disrupts the SCAP/Insig association, thus activating SREBP-1 and promoting lipogenesis to suppor…
https://twitter.com/NatMetabolism/status/1604209063729893376