DaveFinlayTCD @finlayd@social.cleverlibre.org
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
RT @SNI_NKMeeting
Putting together a great program for NK2023, registration opens January 15! More info to come at http://nk2023.org
RT @RCSI_Irl
RCSI research published today in @NatureComms could help improve the effectiveness of #vaccines.
The study shows how our circadian clock is changing the shape of mitochondria within a key immune cell, influencing our vaccine response.
Cable cars 🚠 are great. Wouldn’t have made it on my 2 🦶
Thanks for taking me to see the view @fernojohan and @bjorkstrom_lab. Here in Bergen to examine their fantastic student Martha, who just aced her viva.
RT @SahilBloom
Researchers studied the effects of a 20-minute walk on the cognitive performance of a group of children.
This is fascinating…
RT @lynchielydia
"Fundamental science takes time and patience... and must be allowed to thrive" https://twitter.com/EricTopol/status/1598001973168857090
RT @AndyHogan82
On what would have been my Dad's 68th birthday - a little nod to him here & my unusual route to biology - https://www.siliconrepublic.com/innovation/andrew-hogan-maynooth-obesity-research-immunology
RT @MSularea
Our new review on antiviral immunometabolism in hepatocytes is out today! @MrJamieSugrue @ClionaOfarrelly
https://www.sciencedirect.com/science/article/pii/S0952791522001145
DaveFinlayTCD
boosted
We're up next for #globalimmuno talk this Wednesday, November 30th at 9am PST, noon EST, 5pm GMT. It says #Tcells but there will be some #Bcells and #NKcells too!
Title: "CD4 T cells Sans Frontières"
LINK: ucsd.zoom.us/j/91053505061
How does the non-physiological cell culture conditions affect cellular immunotherapies? A question on lots of peoples minds.
This study suggests controlling oxygen simply at point of CAR-T activation (not thereafter) provides cytotoxicity advantage
Oooh, I do like a lymphocyte adopting a novel metabolic configuration 😁🤓.
Resilient anti-tumour CD8 T with high Malic enzyme 1 expression.
ME1 makes glycolysis independent pyruvate and NADPH - the first for energy, the second supports GSH levels.
This one from John O’Shea’s group ticks a lot of boxes for me: common γ cytokine receptors, IL2, STAT5, mTOR, Myc, metabolism……all with genome wide analyses. 😁 nice!!
Lipid overloaded alveolar macrophages when they lack a NK cell receptor 🤔
NKR-P1B, best known as a NK inhibitory receptor, is required by alveolar macrophages to shape its metabolic configuration. KO AM take up more lipid but can’t metabolise it.
RT @LabWaggoner
Reproductive failure may be caused by global reduction in expression of uNK receptors important for interaction with HLA-C and HLA-G on EVT during early pregnancy, leading to reduced uNK activation @VikiLovesFACS https://www.biorxiv.org/content/10.1101/2022.11.25.517971v1
Surprising data showing that “MMR vaccination induces a trained immunity phenotype in γδ T cells”. Effect on γδ T cells is much greater than for NK cells and monocytes, known for their trained phenotype in response to the BCG vaccine.
RT @Rainmaker1973
How a book written in 1910 could teach you calculus better than several books of today
[Calculus Made Easy, by Silvanus P. Thompson, 1910 - full text pdf: http://bit.ly/2pThkf1 or with the table of contents: http://calculusmadeeasy.org]
Shhhh…do you hear that…👂. That is the sound of a massive energy barrier breaking 💥. Maybe I will do some RNASeq after all 😁
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RT @biorxiv_bioinfo
RNAlysis: analyze your RNA sequencing data without writing a single line of code https://biorxiv.org/cgi/content/short/2022.11.25.517851v1 #biorxiv_bioinfo
https://twitter.com/biorxiv_bioinfo/status/1596183814354530309
@gpollara I think that failure is crucial in developing resilience and perseverance from when we are children. Not a new idea. Inspirational to those who just missed out on a grant - what you learn from this will make you a better scienctist
Interesting study looking at the impact of setbacks on early-career scientists
“Overall these findings are consistent with the concept that ‘what doesn’t kill me makes me stronger’.”
DaveFinlayTCD
boosted
@finlayd And also understanding protein levels can provide insights into regulation, secretome, metabolism, and human disease
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
