PPMOs: A Case Study for Cell-Penetrating Peptide Application. https://onlinelibrary.wiley.com/doi/10.1002/9783527835997.ch15 #Morpholino
LOF variants identifying candidate genes of laterality defects patients with congenital heart disease. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010530 #Morpholino
Synapsin III Regulates Dopaminergic Neuron Development in Vertebrates. https://www.mdpi.com/2073-4409/11/23/3902 #Morpholino
Transposable elements drive the evolution of metazoan zinc finger genes. https://www.biorxiv.org/content/10.1101/2022.11.29.518450v1 #Morpholino
Parental mutations influence wild-type offspring via transcriptional adaptation. https://www.science.org/doi/10.1126/sciadv.abj2029 #Morpholino
Top2a promotes the development of social behavior via PRC2 and H3K27me3. https://www.science.org/doi/pdf/10.1126/sciadv.abm7069 #Morpholino
Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11. https://www.nature.com/articles/s41467-022-34909-y #Morpholino
Microenvironmental Snail1 is a driver of immunosuppression in melanoma. https://www.biorxiv.org/content/10.1101/2022.11.23.517623v1 Vivo-#Morpholino
N-Fluoroalkylated Morpholinos – a New Class of Nucleoside Analogues. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202203248 #Morpholino
Use of vivo-morpholinos for gene knockdown in the postnatal shark retina. https://www.sciencedirect.com/science/article/pii/S0014483522004146 Vivo-#Morpholino
Loss of Apical Sodium Bile Acid Transporter Disrupts Bile Acid Circulation and Reduces Biliary Damage in Cholangitis. https://journals.physiology.org/doi/abs/10.1152/ajpgi.00112.2022 Vivo-#Morpholino
Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac1054/6833243 #Morpholino
Hnf1b renal expression directed by a distal enhancer responsive to Pax8. https://www.nature.com/articles/s41598-022-21171-x #Morpholino
Rassf7a promotes spinal cord regeneration and controls spindle orientation in neural progenitor cells. https://www.embopress.org/doi/abs/10.15252/embr.202254984 #Morpholino
The effect and underlying mechanism of yeast β-glucan on antiviral resistance of zebrafish against spring viremia of carp virus infection. https://www.frontiersin.org/articles/10.3389/fimmu.2022.1031962/full #Morpholino
Developing Therapeutic Splice-Correcting Antisense Oligomers for Adult-Onset Pompe Disease with c.-32-13T>G Mutation. https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_14 #Morpholino
Peptide-Conjugated PMOs for the Treatment of Myotonic Dystrophy.
https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_13 #Morpholino
Morpholino-Mediated Exons 28–29 Skipping of Dysferlin and Characterization of Multiexon-skipped Dysferlin using RT-PCR, Immunoblotting, and Membrane Wounding Assay. https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_11 #Morpholino
Restoring Dystrophin Expression with Exon 44 and 53 Skipping in the DMD Gene in Immortalized Myotubes. https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_7
#Morpholino
Restoring Dystrophin Expression by Skipping Exons 6 and 8 in Neonatal Dystrophic Dogs. https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_6 #Morpholino
It's been all Morpholinos all the time for about 23 years. I'm a scientist with Gene Tools LLC.