jonmoulton @jonmoulton@social.cleverlibre.org

Determining the importance of the stringent response for methicillin-resistant Staphylococcus aureus virulence using a zebrafish model of infection. https://www.biorxiv.org/content/10.1101/2023.07.12.548523v1 #Morpholino

A side-by-side comparison of peptide-delivered antisense antibiotics employing different nucleotide mimics. https://www.biorxiv.org/content/10.1101/2023.07.11.548539v1 #Morpholino

Minichromosome maintenance protein 10 (mcm10) regulates hematopoietic stem cell emergence in the zebrafish embryo. https://www.cell.com/stem-cell-reports/pdfExtended/S2213-6711(23)00201-1
#Morpholino

Modulation of miR-146b by N6-methyladenosine modification remodels tumor-associated macrophages and enhances anti-PD-1 therapy in colorectal cancer. https://link.springer.com/article/10.1007/s13402-023-00839-0 Vivo-#Morpholino

RAS-independent ERK activation by constitutively active KSR3 in non-chordate metazoa. https://www.nature.com/articles/s41467-023-39606-y #Morpholino

Unnexin is a protein subunit of a large-pore channel expressed by unicellular organisms. https://www.pnas.org/doi/10.1073/pnas.2307898120 #Morpholino

Prediction of human pharmacokinetics of phosphorodiamidate #morpholino oligonucleotides in Duchenne muscular dystrophy patients using viltolarsen. https://dmd.aspetjournals.org/content/early/2023/07/19/dmd.123.001425.long

I am headed for the Society for Developmental Biology conference in Chicago. The tooting of #Morpholino citations will take a break for a week.

Development of small fluorescent probes for the analysis of autophagy kinetics. https://www.cell.com/iscience/fulltext/S2589-0042(23)01295-6 #Morpholino

lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway. https://www.mdpi.com/2073-4425/14/7/1371 #Morpholino

Upf3a but not Upf1 mediates the genetic compensation response induced by leg1 deleterious mutations in an H3K4me3-independent manner. https://www.nature.com/articles/s41421-023-00550-2 #Morpholino

Deep intronic founder mutations identified in the ERCC4/XPF gene are potential therapeutic targets for a high-frequency form of xeroderma pigmentosum. https://www.pnas.org/doi/10.1073/pnas.2217423120 #Morpholino

Synthesis and Biophysical Studies of High Affinity #Morpholino Oligomers Containing G-clamp Analogs. https://chemrxiv.org/engage/chemrxiv/article-details/649ae6c1ba3e99daef1f7404

Identification of protein phosphatase 4 catalytic subunit as a Wnt promoting factor in pan-cancer and Xenopus early embryogenesis. https://www.nature.com/articles/s41598-023-35719-y #Morpholino

Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation. https://elifesciences.org/reviewed-preprints/87434 #Morpholino

UBAP2 plays a role in bone homeostasis through the regulation of osteoblastogenesis and osteoclastogenesis. https://www.nature.com/articles/s41467-023-39448-8 #Morpholino

Patent
Morpholino oligonucleotides useful in cancer treatment
https://patents.google.com/patent/US11679121B2/en
Includes delivery of #Morpholinos by irradiation

Transmembrane protein 150b attenuates BMP signaling in the Xenopus organizer. https://onlinelibrary.wiley.com/doi/10.1002/jcp.31059 #Morpholino

The Crucial Role of CTCF in Mitotic Progression during Early Development of Sea Urchin. https://onlinelibrary.wiley.com/doi/10.1111/dgd.12875 #Morpholino

Defective neurite elongation and branching in Nibp/Trappc9 deficient zebrafish and mice. https://www.ijbs.com/v19p3226.htm #Morpholino