📢 New preprint out ! 📢
We investigate how and why the disruption of the astrocyte network (through the KO of gap junctions) affects the neuronal bursting phenotype.
Combining experiments and a new mathematical model based on synaptic short-term plasticity we found that the main affected mechanism is afterhyperpolarization through KCNQ channels regulation !
https://www.biorxiv.org/content/10.1101/2022.12.14.520502v1
#astrocytes #glia #neuroscience #modeling #dynamicalSystems #afterhyperpolarization
@kswilcox thanks a lot !!