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Tavo boosted
Thiago Carvalho

I love Current Biology - probably my favorite journal ever since I haunted the university library waiting for each new issue to read Sidney Brenner's Loose Ends. But maybe "Free Vaginas" is not the best layout option for their webpage.

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Tavo

A consequence of not knowing the seasonality behind COVID-19 is that some activities are inherently safer. Positivity peaks around midday and SARS-Cov2 follows patterns of solar activity, mainly UVB.

Other examples of its seasonality are winter and summer as well as the min and max points within the solar cycle. Finding other similar points could help to understand its transmission.

Grouping cases and environmental data by day of the week shows a linear correlation between changes in atmospheric ozone and cases.

This specific pattern as well as all the data hints that the bulk of the transmission happens in the daytime. And something similar happens at weekends.

Engaging in activities at low susceptibility conditions will lead to believe that everything is safe. But it was just less likely to happen.

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Tavo boosted
🇳🇱 Covid Analytics NL

💩🇳🇱 Wastewater SARS-CoV-2 RNA flow per capita on a national level at 32514314 and moving down.

Half-life at 14 days.

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Tavo boosted
Renshaw01

Meet 10 Women in Science Who Changed the World

Great article in the March Discover magazine. The 10 women mentioned in the article are:
1. Ada Lovelace, Mathematician
2. Marie Curie, Physicist and Chemist
3. Janaki Ammal, Botanist
4. Chien-Shiung Wu, Physicist
5. Katherine Johnson, Mathematician
6. Rosalind Franklin, Chemist
7. Vera Rubin, Astronomer
8. Gladys West, Mathematician
9. Flossie Wong-Staal, Virologist and Molecular Biologist
10. Jennifer Doudna, Biochemist

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Tavo

covid variant data, machine learning 

@beadsland yes that's why I started to write a substack trying to explain everything a little bit more in depth but I'm not sure if I'm making myself clear.
open.substack.com/pub/tavoglc/
I think this is a somewhat complete index of all the work I've done regarding COVID. Code, examples, blog posts and another preprint.
github.com/TavoGLC/SARSCov2Sol
And it's exactly a marketing campaign, the phrase was used on a TensorFlow advertising from last year.

Thanks I think I'm going to make a web app or something like chat GPT, perhaps that brings a little bit more attention.

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Tavo

covid variant data, machine learning 

@beadsland yeah is for people in general just try to get the word around. I think bulk of the transmission happens at daytime and things that aid the circadian rhythm could be used as prophylactic treatment in general. And a bunch of viruses will pop out of nowhere for at least 15 years.

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Tavo

covid variant data, machine learning 

@beadsland you're right is the alternative to TensorFlow, although there's also a TensorFlow version of most of the models. There are examples linked on the GitHub repo in the paper. And live examples at kaggle for most of the models and datasets.

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Tavo

covid variants map USpol 

@beadsland don't wait for the new variant to rise out of nowhere predict it yourself with jax. researchsquare.com/article/rs-

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Tavo

@Syphilia@todon.eu want to know why ? researchsquare.com/article/rs-

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Tavo

@NatalieDavis don't wait for the new variant make your own with jax. researchsquare.com/article/rs-

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Tavo boosted
nathan@fosstodon:~$:idle:

Sounds like Laura Loomer has long Covid

#USPol #Politics #LauraLoomer #GOP #AltRight #RightWing #COVID #LongCOVID

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Tavo

Tired of all those COVID variants? get ahead of the game, and predict them yourself with JAX.
github.com/TavoGLC/SARSCov2Sol

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Tavo boosted
Simon Willison

Being able to pipe code to an LLM in the terminal is really fun

`symbex Request | llm --system 'add type hints to this'`

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Tavo

PPP1R12A is a gene involved in the regulation of microvilli in nasal epithelial cells. This pathway has been suggested as a target for SARS Cov 2 infection. .
sciencedirect.com/science/arti

Mutations in PPP1R12A can lead to a condition known as Coronary Artery Vasospasm, a condition related to angina pectoris and orthostatic intolerance. .
malacards.org/card/coronary_ar

Cases of coronary vasospasms have been reported in COVID-19 patients but in low numbers.
sciencedirect.com/science/arti

C9orf72 is a gene related to Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis a neurodegenerative disease. Patients with mutations on C9orf72 have a propensity toward psychosis or hallucinations.
malacards.org/card/frontotempo

Specific mutations in C9orf72 have been found to influence SARS Cov 2 infection and perhaps drive it toward a more pathogenic phenotype.
mdpi.com/1422-0067/22/13/6991

Mutations in TRNT1 can lead to Sideroblastic Anemia with B-Cell Immunodeficiency, Periodic Fevers, and Developmental Delay.
malacards.org/card/sideroblast

Mutations in TRNT1 could also be used as a risk factor for COVID-19. A case report study shows recurrent infections in patients with such mutations.
bmcinfectdis.biomedcentral.com

RORA is a gene related to Intellectual Developmental Disorder with or Without Epilepsy or Cerebellar Ataxia and Autism.
malacards.org/card/intellectua

RORA SNPs have also been found to be differentially expressed in different COVID-19 phenotypes. frontiersin.org/articles/10.33

Also, RORA is differentially expressed in heart failure among other genes. .
onlinelibrary.wiley.com/doi/fu

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Tavo boosted
Infectious Disease Tracker

Florida 🇺🇸 reports its first known case of chronic wasting disease (CWD) in a white-tailed deer in Holmes County.

CWD is a prion disease that affects deer, elk, reindeer, sika deer and moose. It has been found in some areas of North America, Norway and South Korea.

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Tavo boosted
Infectious Disease Tracker

⚠️ BREAKING:

Peru's 🇵🇪 health minister resigns as dengue fever case count surpasses 146,000 with 248 deaths in the country's largest dengue outbreak ever.

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Tavo

ADAM10 is a gene related to the neurodegenerative Alzheimer's disease.
malacards.org/card/alzheimer_d

Regarding SARS Cov2 infection ADAM10 mediates the priming of the spike protein and lung cell fusion.
embopress.org/doi/full/10.1525

ADAM10 inhibition reduces the entry of viral particles in cell culture.
journals.asm.org/doi/full/10.1

ADAM10 inhibition by Disulfiram has shown positive effects, as it inhibits the interaction between ACE2 and the spike protein in cell culture.
ncbi.nlm.nih.gov/pmc/articles/

While patients treated with Disulfram for alcohol user disorder showed a reduced risk for COVID-19.
ncbi.nlm.nih.gov/pmc/articles/

PDE4D is a gene related to Acrodysostosis 2 with or Without Hormone Resistance a condition with endocrine abnormalities and in females irregular menses.
malacards.org/card/acrodysosto

Although there's no information linking PDE4D and some SARS Cov 2 components, targeting it has been successful.

Tanimilast regulates the immune activation derived from SARS Cov 2 ssRNA. .
frontiersin.org/articles/10.33

While Dyphylline showed antiviral activity in cell culture, its effect is attributed to an off-target effect.
future-science.com/doi/full/10

CAMK4 is a gene related to autism and Cerebral hypoxia disease. A disease characterized by "Having a hard time paying attention * Poor judgment and decision making * Memory loss * Having a hard time controlling movement"
malacards.org/card/cerebral_hy

Clinical data shows elevated levels of CAMK4 in the kidneys of COVID-19
patients.
sciencedirect.com/science/arti

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Tavo boosted
Julie Webgirl - Just Your Luck

"Basic antibiotics have been in short supply in the US since October, when rising rates of respiratory infections led to increased demand for amoxicillin..."

Gee, I wonder why.

Rising rates of respiratory infections.

How odd.

#CovidIsNotOver #LongCovid #Covid

Pfizer Sees Antibiotic Supply Running Out as Shortage Worsens

bloomberg.com/news/articles/20

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Tavo boosted
Infectious Disease Tracker

Dengue fever cases tripled in Cambodia 🇰🇭 compared to the same time period last year.

3,439 cases have been reported in the country so far in 2023.

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Tavo

INPP4B is differentially expressed in COVID-19 patients. Particularly had a negative correlation with disease severity.
sciencedirect.com/science/arti

DSC2 is a gene related to Arrhythmogenic right ventricular cardiomyopathy. A disease characterized by the breakdown of the myocardium and an increased risk of sudden death.
medlineplus.gov/genetics/condi

SARS Cov 2 infected cardiomyocytes with mutations in the DSC2 gene showed an increased viral load in cell culture.
jacc.org/doi/full/10.1016/S073

LAMP2 is a gene related to Left Ventricular Noncompaction, this disease is characterized by impaired cardiac development. Some of the symptoms of this disease are blood clots, shortness of breath, exercise intolerance, and sudden death.
malacards.org/card/left_ventri

LAMP2 also has a role during SARS Cov 2 infection, as a specific spike mutation accumulates in LAMP2-positive membranes.
ncbi.nlm.nih.gov/pmc/articles/

Furthermore, LAMP2 interacts with the 5' end of the SARS Cov 2 genome regulating the amount of viral RNA inside the infected cell.
journals.asm.org/doi/full/10.1

High expression of AGPAT5 in the livers of COVID-19 patients has been found.
nature.com/articles/s41392-020

TLR3 mutations are related to immunodeficiency that increases the susceptibility to herpes simplex virus (HSV), varicella-zoster virus (VZV), influenza A virus (IAV), hantavirus, and possibly respiratory syncytial virus (RSV).
malacards.org/card/immunodefic

Also, mutations in TLR3 are markers of COVID-19 disease severity in males.
tandfonline.com/doi/full/10.10

TLR3 induces the innate immune response against the SARS-Cov2 infection.
mdpi.com/1999-4915/14/2/189

A case report of interferon therapy in patients with TLR3 mutations shows that interferon therapy could be beneficial to patients that present such mutations.
link.springer.com/article/10.1

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