Tavo @tavoglc@social.cleverlibre.org

Specific molecular machinery involved in circadian regulation and highjacked by SARSCov2 infection has already been found. BMAL1, a protein that interacts with CLOCK to synchronize the circadian rhythm, regulates the entry of the virus into the cell. #COVID19 #LongC
https://www.sciencedirect.com/science/article/pii/S2589004221011123

Involvement between SARS Cov2 and the circadian rhythm has been proposed before. #COVID19 #LongC
https://onlinelibrary.wiley.com/doi/full/10.1002/ctm2.949

Delayed sleep phase disorder(DSPD) and Major depressive disorder are diseases associated with CLOCK. DSPD disrupts the timing of biological rhythms such as sleep, periods of alertness, body temperature, and hormonal cycles. #COVID19 #LongC
https://en.wikipedia.org/wiki/Delayed_sleep_phase_disorder

One of the main regulators of the circadian function inside cells is the CLOCK protein, a gen with high compositional similarity to SARS-Cov. CLOCK is involved in chromatin organization and the circadian cycle. #COVID19 #LongCovid
https://www.genecards.org/cgi-bin/carddisp.pl?gene=CLOCK

Due to its seasonality(solar radiation changes), I think that one of the main dysregulations is the circadian one. Scheduling of circadian events could be disrupted and some daily variations in symptom severity might also be possible. #COVID19 #LongCovid

Posts data and code are free and open source, feel free to subscribe if you think the following can be useful. Supporting this project will allow me to continue to work on these analyses. #COVID19 #LongCovid

This is not medical advice, it's just an effort to broaden the discussion regarding post-acute sequelae and long covid. I have a substack on which I describe other methods to analyze genomic data. #COVID19 #LongCovid
https://tavoglc.substack.com/

The following will be a long evolving thread of previously selected genes with high similarity to SARS-Cov2. And its possible involvement in long covid. But some disclaimers. #COVID19 #LongCovid

Detecting highly similar genes could provide some insight into the kind of dysregulation resulting from the acute phase infection. #COVID19 #LongCovid

If the virus adapts to the cellular resources, then the seasonality of the virus could be traced by measuring an environmental variable or by selecting genes with high similarity to the virus. #COVID19 #LongCovid

This over time creates a series of waves of resources inside the cell. If we frame a viral infection as a resource optimization problem then a virus will have seasons with low and high resource availability. #COVID19 #LongCovid

Changes in the environment generate changes in gene expression patterns. Those changes will also modify the nucleotide and the amino acid pools inside the cell. #COVID19 #LongCovid

Algunos eventos desafortunados debidos a malas decisiones del pasado terminaron acelerado varias cosas.

Would you like to know more?
https://tavoglc.substack.com

Also by approaching polar latitudes the frequency of those periods increases. #COV1D #COVID

If we plot the cases using the sunshine duration as a measure of time the different waves are located at the extremes of the axis. But if we look at how the sunshine duration changes specific rates appear to constrain the duration of the waves #COV1D #Covid

Training a VAE with a custom sequence representation sports the different genomes by a temporal variable. Currently, the best fit is the sunshine duration rate of change. A proxy measure of the rate of change of solar radiation at a specific location. #COV1D #Covid

In the case of COVID-19, the data source will be the genomic sequences obtained through genomic surveillance. #COV1D #Covid