Tavo @tavoglc@social.cleverlibre.org

Animal models for long Covid, review at #PlosPathogens

"We review SARS-CoV-2 infection and disease manifestations in mice, Syrian hamsters, ferrets, and nonhuman primates (NHPs). Specifically, the virology, pathology, immune responses, and multiorgan involvement are summarized. These models are rationally examined for their use in understanding the complexities of the multiorgan involvement during Long COVID and the potential for their use in screening therapeutics such as anti-inflammatory drugs, which are currently used for treating other diseases. The aim of this review is to highlight Long COVID preclinical animal models that could be used for Long COVID research and to screen for pharmacological interventions."

#Covid19 #LongCovid #Covid #SarsCoV2

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010741

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A group of human brain cells, grown in a lab, learned to play Pong: https://www.bbc.com/news/science-environment-63195653

They couldn't play it *well*! But it was hitting the ball with well above random chance

It is both interesting and SUPER UNSETTLING but there you go

Roche anti-aggregated beta-amyloid monoclonal fails in phase III.

"The Swiss drugmaker said on Monday that two phase 3 trials of its antibody drug gantenerumab did not slow the decline in people with early- stage Alzheimer’s disease, with both failing to meet their “primary endpoint”, or most important research objective."

#Alzheimer

https://www.ft.com/content/df20b1b7-6368-44bb-803d-b8602d575275

"There are difficult decisions ahead on tax and spending. But some cuts, such as shrinking investment in research and development, would prove a tragically misguided false economy — and show that the UK had failed to learn from mistakes that have hampered us in the past."

#SciencePolicy #ScienceFunding

https://www.ft.com/content/aadb50d1-9025-4109-a123-f62f4113aeca

Since it proves challenging to find everybody at #mastodon, I thought it would be useful to add a little #introduction to my profile!
I am a neuroscientist, heading the research group Olfactory Coding at the MPI in Jena and interested in olfactory circuits, sensory processing and plasticity in #Drosophila. Key techniques are 2P functional imaging, SSR, anatomical tracing, neuronal reconstructions, neuro-/ optogenetics and diverse behavioral assays to study innate/ learned olfactory behavior.

I like how Mastodon breaks social media. A like button is the secret sauce that controls the masses. But on Mastodon, the like button is just a “send my complements to the chef.” It serves no other purpose.

If you download your Twitter archive it arrives wrapped as a static HTML page, which is not very useful for doing anything with, and worse: it requires the original account to be still active to do useful things like enlarge the images since they use t.co links.

So here's a Python script to convert a Twitter archive to markdown or other formats: https://github.com/timhutton/twitter-archive-parser

Now you can archive your tweets in any way you want.

In a recent study, researchers created #brain organoids and infected them with #COVID19.

They found that “an excessive number of synapses were eliminated – more than you would expect to see in a normal brain.”

https://www.psypost.org/2022/11/long-covid-study-suggests-lost-connections-between-neurons-may-explain-cognitive-symptoms-64291

#Research #science #health #mentalhealth #medicine #covid #longcovid #psychology #psychiatry #neuroscience #neurology

This morning, Health Department OIC, Dr. Vergeire mentioned the recent study on the risk of long term #COVID19 complications depending on the number of #reinfections.

This is a first! Are we reaching a breakthrough?

I keep seeing lots of long-time #fediverse users saying 'don't favourite posts it does nothing' but actually when you favourite my posts it makes me smile and I'm sure I'm not the only one.

#Change is when you see the opportunity. Transition is when you adopt it...

📢New episode !

We interview Dr Elisabeth Bik (@MicrobiomDigest ) on fraud in scientific publications

Listen here:
https://open.spotify.com/episode/5Wo8cdlEap9jq8s4MvBhiK?si=16a9f0786af140bd

#academia #PhD #science #xp @OpenAcademics @AcademicChatter

Looks like we're all getting out our @Introduction (thanks for the idea @JeffLieber ) Hi, I'm Adam, a former Army Officer, current writer/director/producer. I'm currently freelance and looking for full time work.
I'm a published author, award-winning screenwriter, and even wrote and directed live musical theater. I'm currently working on new pilots, features, and a pirate-based musical! Oh, and I host trivia nights in NoHo. #writing

For neuroscientists attending #sfn22: don’t miss the poster by Mitya Chklovskii’s group describing the completion status of the whole brain #connectome of the fairy wasp #Megaphragma, of expected completion early in 2022. Find the poster tomorrow Monday morning, number 328.16 / YY35.

Mitya kindly shared the poster image publicly elsewhere.

This tiny #wasp is famous for being the size of a large paramecium (a unicellular organism) and for enucleating the vast majority of its central neurons while pupating. The adult has less that 10,000 neurons in its central brain yet it isn’t missing any organ or body part. See the paper that jumpstarted this effort:

Polilov AA. The smallest insects evolve anucleate neurons. Arthropod structure & development. 2012 Jan 1;41(1):29-34. https://www.sciencedirect.com/science/article/pii/S1467803911000946

#neuroscience #connectomics

#introduction
PhD candidate in the Pornillos Lab. #cryoEM and #biochem to study #HIV capsid-host interactions. #Girldad #Horselife #biking #homerenovation #homestead

Charles Dana Gibson, Sweetest story ever told (ca. 1910)

#drawings https://artvee.com/dl/sweetest-story-ever-told/