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Hao Yin boosted

Hi #MedMastodon! 👋

#Introduction: I'm an #Endocrinologist at #Stanford, specializing in #Osteoporosis and #MetabolicBoneDisease. My lab studies #StemCells in bone 🦴 and the bone marrow microenvironment.

Some of my favorite topics: #WomenInMedicine #WomenInSTEM #PhysicianScientists #AAPI

Hao Yin boosted

I guess I should introduce myself #onhere: I am a postdoc in the Schier Lab at the Biozentrum (Switzerland). I am using #zebrafish to understand the #development of the nervous system. I love developmental biology of classic and non-canonical organisms, microscopy, loud music and comic books. Very much looking forward to meeting other scientists and cool people!
PS: I also help co-managing @ZebrafishRock , so make sure to give them a follow for the latest zebrafish community news

Evidence on in human

Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction & occurs during multiple sclerosis pathophysiology

Dr. Helga de Vries lab Cell Death Dis 2019
nature.com/articles/s41419-018

ARF6 GTPase links IL-1β inflammation with TGFβ/BMP-SMAD1/5

EC Arf6 KO in🐭->
⏫
⏬T cell infiltration & demyelination
w/o altering normal immunity

Dr. Shannon Odelberg, Weiquan Zhu labs Neuron 2022
sciencedirect.com/science/arti

Hao Yin boosted

Issue 21 is complete!

On the cover is a 3D surface rendering of a lung lobe from a mouse #embryo, showing the relationship between the arterial network (red) and the lung epithelium (grey) from Chandrasekaran et al.

Also in Issue 21:
- 8 #Research Highlights
- In #preprints article on reconstituting the ovary
- Ruth Bellairs obituary
- 2 author interviews
- Poster & article on resolving #morphogenesis into quantifiable cell behaviours
- Nuclear movement Review

journals.biologists.com/dev/is

Hao Yin boosted

Meet the #preLighters: Chee Kiang (Ethan) Ewe. 🌟

prelights.biologists.com/news/

Ethan is a #postdoc in the lab of @Odedrechavi at Tel Aviv University, Israel, where he studies the molecular basis of epigenetic #inheritance.

We spoke about his very international #career, the #mentors along the way, his future #goals, and the importance of #preprints both to him and the biological #community.

#Introduction #Interview #ECRs

Hao Yin boosted

Ooh another really interesting paper on #alzheimers and #lactadherin

Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease

nature.com/articles/s41586-022

Phospholipase Cε

Plce1 KO🐭 are susceptible to ANGII-induced ascending +Dissection

Role of adventitial myofibroblast cytokines?😎

Dr. Alan Smrcka, Santhi Ganesh, Markus Bitzer labs AJP Heart Circ 2022
journals.physiology.org/doi/ab

Hao Yin boosted

A new #SpatialTranscriptomics technique was published on Cell! The authors used polony gels to capture the RNA in situ, and used pixel-seq to map #singlecell transcriptomes back to the tissue. Amazing experimental design! cell.com/cell/fulltext/S0092-8

Hao Yin boosted
Hao Yin boosted

Kidney epithelial

CD24+ epithelial progenitor-derived
4-phase protocol, Matrigel +Wnt3a/RSPO1, grow > 6 mo
CRISPR modeling , Cyst size responsive to

Super-impressive single-cell or single-nuclei RNAseq analyses to dissect the spatiotemporal molecular/cellular dynamics of this cool renal tubuloid, laying a critical foundation to enhance its clinical utilities👍

Wonderful of CD24+ epithelial progenitor-derived nephrospheres, day 7 in Matrigel🤠

Dr. Rafael Kramann lab @NatureGenet 2022 @jackxuyx @KuppeChristoph @rkramann
nature.com/articles/s41588-022

Hao Yin boosted

Welcome @karinayaniv ! I’m also just testing the waters here. I like it :) Slowly but surely finding all ours friends and colleagues! #science

Hao Yin boosted

Slides of my talk "An ABC of fluorescent proteins: Advances, Brightness and Considerations" presented at Symposium of the Microscopy Imaging Center (MIC) in Bern 2022 are available on Zenodo: doi.org/10.5281/zenodo.7341801

Editing a gateway for across

An excellent review🤠 Learn a lot!

Lesson from Leukocyte- interaction->
Engineering strategies->
⏫Cell delivery to injured🧠

Dr. Rust Ruslan lab Brain 2022
academic.oup.com/brain/advance

Hao Yin boosted

MEK1

P1 topical 4OHT-induced mosaic EC MEK1 K57N transgene (what is the efficiency🧐)->
50% death by P30 +multiorgan VM (Arteriovenous malformation or other lesions) & Hemorrhage

Lesions composed of both mutant & WT EC

Dr. Patrick Smits lab Angiogenesis 2022
link.springer.com/article/10.1

Hao Yin boosted

The latest from the lab spearheaded by @vijaykrishnarag: Cell derived matrices from bovine corneal endothelial cells as a model to study cellular dysfunction. @nationaleyeinstitute sciencedirect.com/science/arti

Hao Yin boosted

Hi everyone👋 #preLights is a #preprint highlights service run by the biological #community and supported by #Co_Biologists allowing researchers to:

🔎 Sift through the growing volume of preprints.
💡 Highlight new thinking or new techniques across the biological sciences.
📝 Comment on preprints that are of particular interest.
👥 See comments and opinions of other researchers.

Toots from Reinier Prosée, the preLights community manager.

#Introduction #Biology #ECRs #Science #AcademicMastodon

12q, an optimized small chemical activator of
Comprehensive analyses vs MDL-800->
⏫Sirt6 deacetylase & demyristoylase activities
⏫Anti- activity

Look forward to more studies on its Non-tumoral benefits?🧐

Dr. Shengyong Yang lab J Med Chem 2022
pubs.acs.org/doi/full/10.1021/

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