Apple pie @applepie@social.cleverlibre.org

#JobOffer: We are looking for an associate #professor in #genomics. Please apply or share!

The application deadline is 16/01/2023.

https://www.jobbnorge.no/en/available-jobs/job/230702/associate-professor-in-genomics

Intro post: PhyloPic is a website by @keesey with thousands of organism silhouettes available under Creative Commons licenses. Everything is taxonomically indexed, so you can find related species, or search all silhouettes within a clade. And anyone can submit silhouettes through the Contribution Website! Have a look at the beta version of PhyloPic 2.0: https://beta.phylopic.org

2 years ago, I jumped into the personal knowledge management craze, especially the #zettelkasten system, as implemented in Obsidian or (in my case) org-roam on top of #Emacs .
How did it go?

I've actually kept using it this whole time!

How do I use it? Mainly, when I learn about a new topic, I make a new note for that topic. For instance, I got obsessed with Lagrangians towards the end of 2020 and made a note about that. I later made more notes for "Lagrangian biomechanics" and "Non standard Lagrangian". The new thing here is the concept of "backlinks". Each of the 2 notes above link to "Lagrangian", and so just by going to "Lagrangian" note I can see the notes linking to that. It's really magic! I often rediscover notes I wrote months ago and almost always find what I stashed away.

I find this most useful for literature reviews or just to recollect my thoughts about specific subfields. I also have notes for books, admin stuff (like one with all the zoom links), ideas for stories, class notes, and notes on how to do things.

One revelation about the zettelkasten system I got from browsing Scott Scheper's materials, https://zettelkasten.de/posts/introduction-antinet-zettelkasten/ , is how useful it is to have a full tree hierarchy, rather than a set of interconnected notes. I do this in org-roam by linking to the "parent" at the top of each note. This makes the graph so much more browsable and naturally interconnects subjects. Just go up and down the hierarchy to see links!

#zettelkasten #workflow #academia

#PROTAB proteolysis-targeting antibody
An evolving #PROTAC variant

Use tumor-enriched cell surface #E3Ligase RNF43/ZNRF3 for targeted degradation of transmembrane proteins IGF1R/HER2/PD-L1

Dr. N. Agard & F. de Sousa e Melo labs @Nature 2022 @genentech
https://www.nature.com/articles/s41586-022-05235-6

Something I find fascinating is how different #germline mutations can affect the risk of acquiring somatic mutations and #cancer. In this recent #hematology paper, the authors found that germline #DDX41 mutations lead to myeloid neoplasia with a different spectrum of somatic mutations. Intriguingly, they also found that DDX41-mutated patients did not have worse survival even with acquired #TP53 mutations (which is normally very bad!): https://ashpublications.org/blood/article/doi/10.1182/blood.2022018221/486974/Germline-DDX41-mutations-define-a-unique-subtype #science #medicine #genomics

An #introduction into our work on #glycotime! We are a lab joint between the Francis Crick Institute and the Department of Chemistry at Imperial College London. We develop what we call chemical "precision tools" to investigate protein #glycosylation. These tools are specific for individual #glycosyltransferases, #glycan subtypes or cell lines. We employ methods of #chembio including #OrgChem, protein engineering, #glycoproteomics, #imaging, #chemoenzymatic synthesis and drug discovery.

#introduction: I am obsessed with the biology of #hallucinations and #delusions.

I am a #newPI at the Francis Crick Institute, London. In our lab, the #Psychosis Collective, we study the neural circuits and immune processes underlying unfounded perceptions and thoughts 🐭 👤 . I look forward to great #neuroscience #immunology #neuroimmunology #psychiatry here!

This is me moving to London without ever having been to London before.

I freaking love chromoproteins. Legit all I want to do is make new ones and share them with y'all. No IP, just vibes.

Would be neat to have an auto language translator in the extension app..

My #introduction is that I'm a 3rd year graduate student in #biochemistry and #molecularbiology .
I study the RAG1/2 recombinase and its binding motif, which facilitates V(D)J recombination. I am actively trying to improve my knowledge and use of #programing #datascience and #machinelearning . Though I am fairly new to programing in general.

I have Functional Movement Disorder, which causes me to have episodes of shaking and various other symptoms.

I enjoy growing #plants and spending time in my #greenhouse and in the outdoors. I grow succulents, cactus, tropicals, and orchids.

When selecting a lab, prioritize mentoring. A good mentor will invest in your success & will be committed to provide you with the space/resources/training/network for you to thrive. Find the lab that will make you feel part of it.

#mentoring #graduatestudent #introduction #mastodon #twitter

Hi
My names in Nicolas, and as many you come from Twitter. I am #Biologist by training, and currently I am finishing a PhD in medicine, where I am studying how #DNAmethylation (#epigenetics) is associated with cardio metabolic phenotypes, such as insulin resistance and diabetes. I have also collaborated in other projects related to the genetics field in general. In my daily basis use #R, and want to learn #python and #machinelearning.
Aside for my academic interest, I am really interested in weird #movies in a wide spectrum of genres, I love both classic and mainstream #literature. I like #art in general, and enjoy going to museums.
Also really into #memes, I CAN see them all they and my day will be fulfilled he. Hope to meet good folks here!

You know who you are😂

#AcademicTwitter #phdlife #phdmemes