Apple pie @applepie@social.cleverlibre.org

#PROTAB proteolysis-targeting antibody
An evolving #PROTAC variant

Use tumor-enriched cell surface #E3Ligase RNF43/ZNRF3 for targeted degradation of transmembrane proteins IGF1R/HER2/PD-L1

Dr. N. Agard & F. de Sousa e Melo labs @Nature 2022 @genentech
https://www.nature.com/articles/s41586-022-05235-6

Something I find fascinating is how different #germline mutations can affect the risk of acquiring somatic mutations and #cancer. In this recent #hematology paper, the authors found that germline #DDX41 mutations lead to myeloid neoplasia with a different spectrum of somatic mutations. Intriguingly, they also found that DDX41-mutated patients did not have worse survival even with acquired #TP53 mutations (which is normally very bad!): https://ashpublications.org/blood/article/doi/10.1182/blood.2022018221/486974/Germline-DDX41-mutations-define-a-unique-subtype #science #medicine #genomics

An #introduction into our work on #glycotime! We are a lab joint between the Francis Crick Institute and the Department of Chemistry at Imperial College London. We develop what we call chemical "precision tools" to investigate protein #glycosylation. These tools are specific for individual #glycosyltransferases, #glycan subtypes or cell lines. We employ methods of #chembio including #OrgChem, protein engineering, #glycoproteomics, #imaging, #chemoenzymatic synthesis and drug discovery.

#introduction: I am obsessed with the biology of #hallucinations and #delusions.

I am a #newPI at the Francis Crick Institute, London. In our lab, the #Psychosis Collective, we study the neural circuits and immune processes underlying unfounded perceptions and thoughts 🐭 👤 . I look forward to great #neuroscience #immunology #neuroimmunology #psychiatry here!

This is me moving to London without ever having been to London before.

I freaking love chromoproteins. Legit all I want to do is make new ones and share them with y'all. No IP, just vibes.

Would be neat to have an auto language translator in the extension app..

My #introduction is that I'm a 3rd year graduate student in #biochemistry and #molecularbiology .
I study the RAG1/2 recombinase and its binding motif, which facilitates V(D)J recombination. I am actively trying to improve my knowledge and use of #programing #datascience and #machinelearning . Though I am fairly new to programing in general.

I have Functional Movement Disorder, which causes me to have episodes of shaking and various other symptoms.

I enjoy growing #plants and spending time in my #greenhouse and in the outdoors. I grow succulents, cactus, tropicals, and orchids.

When selecting a lab, prioritize mentoring. A good mentor will invest in your success & will be committed to provide you with the space/resources/training/network for you to thrive. Find the lab that will make you feel part of it.

#mentoring #graduatestudent #introduction #mastodon #twitter

Hi
My names in Nicolas, and as many you come from Twitter. I am #Biologist by training, and currently I am finishing a PhD in medicine, where I am studying how #DNAmethylation (#epigenetics) is associated with cardio metabolic phenotypes, such as insulin resistance and diabetes. I have also collaborated in other projects related to the genetics field in general. In my daily basis use #R, and want to learn #python and #machinelearning.
Aside for my academic interest, I am really interested in weird #movies in a wide spectrum of genres, I love both classic and mainstream #literature. I like #art in general, and enjoy going to museums.
Also really into #memes, I CAN see them all they and my day will be fulfilled he. Hope to meet good folks here!

You know who you are😂

#AcademicTwitter #phdlife #phdmemes