Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
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Let's give a spin to this! th here a Milanese splinter of the #drosophila community. Fly pushing since 1999
"The ability of thymic macrophages to engulf apoptotic thymocytes is well appreciated, but little is known about their ontogeny, maintenance, and diversity. Here, we characterized the surface phenotype and transcriptional profile of these cells and defined their expression signature."
Thiago Carvalho
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if you had to crosslink a small molecule like a drug to an inert matrix (eg agarose or beads) in as random a way as possible (ie the small molecule will be presented in many orientations) - what would you choice of linker be? can you source the matrix+linker already made? Thanks!
'The virus is ripping through the Chinese capital just a week after authorities abandoned nationwide zero-Covid controls with little forewarning, leaving many Beijing residents struggling to find medication and access medical care. The surge is pushing the healthcare system to its limits, with medical workers in the capital asked to remain on the job even if they are infected.'
https://www.ft.com/content/73eba78a-1bdb-4b32-be3e-b0329470b946
Thiago Carvalho
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Here is an incomplete list of journalists that Elon Musk has suspended from Twitter today.
He also suspended the Twitter account of Mastodon.
It's Going Down
Matt Bider
Aaron Rupar
Donie O’Sullivan (CNN)
Drew Harwell (Washington Post)
Ryan Mac (NY Times)
Matt Binder (Mashable)
Tony Webster (award winning freelancer)
Micah Lee (the Intercept)
Keith Olbermann
Elon Musk bought Twitter in order to suppress free speech and consolidate control of the spaces in which public discourse takes place to advance his authoritarian quest for profit and power. It's necessary to oppose him the way we would fight against any aspiring tyrant, any oppressor.
crimethinc.com/TwitterCanary
'Among other things, the latest report makes unmistakably clear that whatever Chevron, BP, Shell, Exxon and other members of the American Petroleum Institute may say about their climate policies, their investments show that they intend to continue producing and selling oil and gas deep into the future — and well beyond the carbon budgets implied by any of the world’s climate goals.'
https://www.nytimes.com/2022/12/15/opinion/chevron-exxon-shell-bp-climate-change-ro-khanna.html
Thiago Carvalho
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Postdoc position! Pls boost!
Want to devote your expertise in data science to accelerate the pace at which new medicines are found?
Join our lab at the Broad Institute in Cambridge, MA, USA to glean insights from biological images!
More info: http://broad.io/mlcbpostdoc
The Broad Institute provides a uniquely stimulating environment to advance and apply data science in collaboration with MIT, Harvard, and hospitals. (1/2)
Thiago Carvalho
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I am starting to lose track of all the new CRISPR enzymes:
Thiago Carvalho
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I’m a #cognitive and human #neuroscientist at #CarnegieMellon studying #logic and #concepts across species, age, and culture to try to find out #whatmakesushuman.
A few years ago, when I worked at a different university, a bunch of us were whistleblowers and it caused the president of the university to resign #metoo
Thiago Carvalho
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#introduction I am an assistant professor at the University of Rhode Island. I study spinal cord physiology and pathophysiology. My specialty is intracellular recordings of spinal motoneurons in vivo.
I am a pro #OpenScience and #OpenSource #FOSS. I love to write software (badly) and tinker with electronics (generally until the magic smoke comes out).
Thiago Carvalho
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#MastodonNews Dec 15, 2022
Forbes: Twitter Suspends Accounts For Rival Mastodon And Several High-Profile Journalists >>> https://www.forbes.com/sites/nicholasreimann/2022/12/15/twitter-suspends-accounts-for-rival-mastodon-and-several-high-profile-journalists/
Business Insider: Musk's Twitter is blocking links to its competitor Mastodon >>> https://www.businessinsider.com/twitter-blocks-links-to-mastodon-competitor-elon-musk-2022-12
Bloomberg.com: Twitter Suspends Accounts of Mastodon, Journalists Covering Musk >>> https://www.bloomberg.com/news/articles/2022-12-16/twitter-suspends-accounts-of-mastodon-journalists-covering-musk
Techdirt: Elon's... Blatant Hypocrisy >>> https://www.techdirt.com/2022/12/15/elons-commitment-to-free-speech-rapidly-replaced-by-his-commitment-to-blatant-hypocrisy-bans-the-joinmastodon-account/
#twittermigration
More News >>> https://medium.com/@mastodonmigration/sharing-advice-and-assisting-with-the-great-mastodon-migration-53c1a286b805#cfd1
Thiago Carvalho
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Ovarian cancer mutational processes drive site-specific immune evasion https://www.nature.com/articles/s41586-022-05496-1
Thiago Carvalho
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A fantastic group of authors, spearheaded by the amazing
@RebeccaSenft and Barbara Diaz-Rohrer
, have a new preprint for your end-of-year-reading lists! In the 🧵, learn a bit more about "A biologist's guide to the field of quantitative bioimaging"
https://zenodo.org/record/7439284#.Y5s_POzMI0R 1/x
Thiago Carvalho
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Thrilled to finally have our paper looking at the role of spatial structure in polymicrobial infections out today in @PNASNews! https://www.pnas.org/doi/10.1073/pnas.2212340119
#ChronicWounds #MRSA #Pseudomonas #SpatialStructure
Thiago Carvalho
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Many years later--in fact, not until 1983--McClintock would win the #NobelPrize for her discovery of mobile genetic elements and gene transposition. Here's McClintock holding an ear of maize:
[pic from https://en.wikipedia.org/wiki/Barbara_McClintock#/media/File:McClintock.jpg]
Thiago Carvalho
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OK, this is an experiment posting longer pieces to #ScienceMastodon, so consider this 1/n.
I wanted to share a fascinating piece of #ScienceHistory that I stumbled across not long ago while rummaging through old papers from early #genetics labs at the University of Texas. Deep in boxes of classic reprints, I found correspondence between Barbara McClintock, the famed Cold Spring Harbor labs maize geneticist, and UT fly geneticist Wilson Stone.
Thiago Carvalho
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The Nobel Prize was awarded for McClintock's work in the 1940's/50's characterizing mobile genetic loci in maize that she named Dissociation (Ds) and Activator (Ac) & how they contributed to the variable colors of maize kernels. She got such strong pushback that, in 1953, she stopped publishing altogether on this work.
The two letters I found date to the year before, 1952, and they're a lovely little treasure trove to a geneticist. Here they are in their entirety:
Tools
"We propose a statistical approach, CS-CORE, for estimating and testing cell-type-specific co-expressions, built on a general expression-measurement model that explicitly accounts for sequencing depth variations and measurement errors in the observed single cell data."
https://www.biorxiv.org/content/10.1101/2022.12.13.520181v1?med=mas
Thiago Carvalho
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Let’s take a moment and share the new and incredible US Postal Service Stamp honoring John Lewis while everyone is talking about Trump’s shitty cards.
'About 300 miles away, at a hospital outside Flint, Mich., similar scenes were unfolding. Chronic understaffing meant that patients languished in dried feces, while robots replaced nursing assistants who would normally sit with mentally impaired patients.
Both hospitals are owned by one of the country’s largest health systems, Ascension. It spent years reducing its staffing levels in an effort to improve profitability, even though the chain is a nonprofit organization with nearly $18 billion of cash reserves.'
https://www.nytimes.com/2022/12/15/business/hospital-staffing-ascension.html
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
