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'Here, we investigate the susceptibility of natural variants of the main protease (Mpro/3CLpro) of SARS-CoV-2 to protease inhibitors. Multiple single amino acid changes in Mpro confer resistance to nirmatrelvir (the active component of Paxlovid).'

biorxiv.org/content/10.1101/20

There's going to be quite a lot to learn about the interactions between viral infections and susceptibility to Group A strep infections once we get through the current wave in 🇬🇧
#GAS #streptococcus #microbiology #IDMastodon
thelancet.com/journals/laninf/

The historic MBL Physiology Course is now accepting applications! If you're interested in learning more about the course and the application process, be sure to join us on Friday, January 13 at 9 AM PT for a virtual open house (berkeley.zoom.us/meeting/regis).

More info about the course is available here: mbl.edu/education/advanced-res

'Inevitably, it raises a question about the purpose of biography. In reviewing the first volume of my own life of Keynes, the economist Maurice Peston wrote: ‘What help is knowledge of the lives of Newton and Einstein in predicting the movement of the planets?’ To which the answer is that economics is not a natural science like physics. One needs to know the economist, and his location in the flow of events, not to test his theories but to judge their value for our own time.'

spectator.co.uk/article/friedr

All 23 of Timothy Snyder’s free lectures on “the Making of Modern Ukraine” are now posted. Millions of people have tuned in — everyone should listen to the whole course (they are also on Spotify).

youtu.be/nLfFmYWjHtc

podcasts.apple.com/us/podcast/

#ukraine #podcast #history #yale #timothysnyder #highered #histodons @histodons

Nice RNA virus paper from earlier this year: Transcriptome Mining Expands Knowledge of RNA Viruses across the Plant Kingdom.

"these data highlight that ... the apparent scarcity of RNA viruses found in lower plants likely reflects a lack of investigation rather than their absence"

journals.asm.org/doi/10.1128/j

#viruses #virology

"In this work, we explored possibility of using drug-sensitivity data together with basal gene expression data on pancreatic cell lines to predict the combinatorial options available for HDACi and developed bioinformatics screening protocol for predictions of synergistic drug combinations in PDAC. "

biorxiv.org/content/10.1101/20

Fission is in the news, but few recognize that a woman physicist was behind the discovery.

Lise Meitner’s brilliance led to the discovery of nuclear fission. But her long time collaborator Otto Hahn, was awarded the Nobel Prize in Chemistry w/o her in 1944, even though she had given the first theoretical explanation.

Albert Einstein called Meitner “our Marie Curie." She also adamantly refused to work on the atomic bomb during WWII. aps.org/publications/apsnews/2 #women #history #science #energy

Here’s one of my favourite artefacts: an ancient amber bear. Carved some 10,000 years ago, it washed up on a beach at Fanø in Denmark, from a submerged Mesolithic settlement.
On display National Museum of Denmark, Copenhagen. Read more about amber from submerged settlements: en.natmus.dk/historical-knowle

#Archaeology
#Art

Staggering charts in the FT by John Burn-Murdoch show that after 12 years of Tory rule we are poorer, sicker and will die sooner than our peers. Utterly disgraceful.

The great Paulino Vieira, the genius of Cabo Verde music. Here, in an thrilling harp solo (1995, Paris). youtu.be/WfUARGzNqY0 via @YouTube

RT @phalpern@twitter.com

At the age of 99, French mathematical physicist Yvonne Choquet-Bruhat, a pioneer in the study of general relativity, is one of the last people alive who engaged in research discussions with Albert Einstein in his office at the Institute for Advanced Study

cqgplus.com/2015/12/14/some-me

🐦🔗: twitter.com/phalpern/status/16

As a human rights lawyer who has done extensive immigration work, let me make something absolutely clear.

Asylum is legal immigration.
There's no "port of entry" requirement.
There's no "visa" requirement.
There's no "first country" requirement.
You enter the United States, and you apply for asylum.

Because asylum is legal immigration. Period.

Period.

RT @Shouval
📢 We are recruiting! The @shouval_lab is looking for bright and motivated researchers interested to join us in our quest to dissect fibroblasts and cancer associated fibroblasts in inflammation and cancer! #Recruiting #CancerResearch

@Aethelred_unread China's mass vaccination campaigns were done with locally developed vaccines that turned out to be significantly less protective than the mRNA vaccines

@gershbrain There's an inspiring paper by @Katejjeffery, Pollack and Rovelli 2019 "On the Statistical Mechanics of Life: Schrödinger Revisited" mdpi.com/1099-4300/21/12/1211 that argues how life, and specifically complex structures, opens up the space of possible variations in the organization of components and therefore more entropy. And that statistically this implies life is entropically favoured.
#entropy #science

Happy to announce that I have been awarded a @snf_ch to study the impact of gut on natural antibodies in patients. Grateful to all reviewers for their positive comments and collaborators who believe in this Project @unibern @inselgruppe @DBMR_UniBe
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RT @snsf_ch
How endemic viruses spread, optimised hardware thanks to AI, and equal opportunities put to the test: 62 researchers receive an SNSF Starting Grant 2022. …
twitter.com/snsf_ch/status/159

'But an abrupt U-turn by Beijing this month on its former zero-Covid policy of containing the disease has sparked an explosion of cases and prompted a surge in the number of mainlanders seeking mRNA jabs in Macau. The former Portuguese colony and special administrative region is the only place outside mainland China where the country‘s citizens can travel without having to quarantine on return.'

ft.com/content/d89551a9-4f7e-4

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