Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
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A Framework for Descriptive Epidemiology: New article by Lesko et al (2022), American Journal of Epidemiology
https://academic.oup.com/aje/article/191/12/2063/6623869 #epidemiology #publichealth #causalinference v @MaartenvSmeden
Thiago Carvalho
boosted
RT @agristok
📌 5 Research Assistant Positions in Agricultural Microbiology, Plant Pathology, Agricultural Machinery and Botany at Free University of Bozen/Bolzano, Italy 🇮🇹... Please Retweet and spread the word! For details visit the link below👉 https://wp.me/pbv48T-4XX
Thiago Carvalho
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Three years ago, on this day, the Wuhan municipal health service put out a notice on unusual cases of pneumonia
https://twitter.com/who/status/1213795226072109058
RT @WHO@twitter.com
On 31 December 2019, WHO was informed of cases of #pneumonia of unknown cause in Wuhan City, #China. A total of 44 cases have been reported: 11 patients are severely ill, while the remaining 33 are in stable condition.
Thiago Carvalho
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Need a good read for your holidays? Have a look at our work showing how too much sugar makes a good protein turn bad. Work with the Chiosis lab at MSKCC, G. Chiosis, M. Castelli, E. Moroni #CompChem #Glycotime #Proteins @eLife @CellChemicalBiology
"Patterns extracted from proteins in the Protein Data Bank (PDB) provide a ready “parts list,” circumventing the folding process entirely. These patterns are “fully baked.” That is, a pattern extracted from a solved structure in the PDB is fully preorganized; any physical–chemical organizing interactions have already been realized during folding. The situation is analogous to interpreting a movie by fast-forwarding to the final scene without first watching the previous two hours; we know how it ends, but we don’t know why."
Thiago Carvalho
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Hi there, it is time for an #Introduction !
We are #Berlin #Bayesians, a group for Bayesian enthusiasts and practitioners based in Berlin. We organize talks (mostly in person, sometimes online) on all things Bayesian.
You can check out our events here: https://www.meetup.com/berlinbayesians/
If you'd like to speak at our meetup you can: present your research, give a tutorial on a Bayesian framework or summarize a paper. Feel free to write us, even if you are not based in Berlin.
Thiago Carvalho
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Hello! An #introduction after weeks of lurking—I'm a #writer, #editor, and #author interested in #conservation, #climate, #science, #environment, #ecology, and paths to a better future. Soft spot for #frogs. Proud to be working with the whip-smart #HighCountryNews team as acting EIC. Grateful to those stewarding the growth of #mastodon.
Next time
"Anyone who visits Pages & Cépages in Paris is not only likely to leave with a bottle of wine; they might also pick up a comic book about wine to enjoy it with. Indeed, this independent wine and bookshop carries around 2,000 books dedicated exclusively to food and wine, a full tenth of which tell their stories through illustrated strips."
From a small producer in Dao (a very underrated region of Portugal), a red
#WinesOfMastodon
cc @BLMG
"E desde o século XV somam-se seis séculos em que a ilustração se senta à mesa com a ciência. Anna Escardó olha precisamente para este período, onde encontra e escolhe os capítulos que espelham esta relação íntima entre a ciência e a ilustração. As conclusões são retiradas pelo leitor, depois de mais de 300 ilustrações compiladas em Ilustração Científica: Uma História do Conhecimento Visual do Século XV até Hoje (editora Taschen), obra escrita em espanhol, inglês e italiano."
https://www.publico.pt/2022/12/31/ciencia/noticia/ciencia-tambem-faz-desenhos-2028240
Thiago Carvalho
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Intriguing scientific insights:
🌍 A protected geotope
🐧 The frozen shadows of Adélie penguins
❄️ Arctic circle in August
Take part in the SNSF Scientific Image Competition.
Deadline: 31 January 2023
"There is literally never a dull shot. And he found in Toshiro Mifune, star of Rashomon and 15 other films in the Kurosawa canon, an antic presence with acting strokes to match. Mifune’s performance is as vivid as a Japanese ideogram. (Note for Kurosawa biographical completists: he studied calligraphy and kendo swordplay as a child.)"
https://www.ft.com/content/29b63a0f-3c30-4de9-9456-fa48118978ff
"If you’re doing that having already written your conclusions, it takes a strong will not to lean—consciously or unconsciously—in your pre-determined direction. The idea that all the low-integrity, low-proficiency stuff happens in the study before any writing takes place is just not an accurate description of how normal, everyday science is done."
https://stuartritchie.substack.com/p/science-isnt-storytelling?utm_medium=web
Thiago Carvalho
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We miss Jony dearly, and I like to imagine that he would be as happy as we are to see this out. We dedicate this paper to him and his family!
Thiago Carvalho
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This work was published together with a study on similar concept but with a very different flavor by our colleagues at the Nussenzweig lab. Short-lived immunization GCs allow quite a bit of invasion too, just following a different set of rules. Check it out!
Thiago Carvalho
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Renan recently put up a thread on the science on the bird site. In a very short summary: flu is a classic way to generate “long-lived” germinal centers in mice, which last for several months (≥1/4 of a mouse’s typical lifespan). Turns out germinal centers last this long not by evolving the same B cell clones over and over, but by constantly replacing old clones with new ones allowing the same structure to persist for a long time. Check out his thread 👇👇👇.
https://twitter.com/deCarvalhoRenan/status/1606336361476366336
Thiago Carvalho
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Enormous credit to the whole lab, but especially to Renan de Carvalho and Alex Barbulescu, who gladly put their main projects on hold to focus on dissecting Jony’s puzzling finding. Renan played a particularly important role in setting the final of shape the story. Thanks also to our many co-authors from the Utz, Rice, Baric, and Mucida labs.
Thiago Carvalho
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Really happy to see this paper is out! It’s the brainchild of our dear postdoc Jonatan Ersching, who passed away in 2020. It’s not only a science story, but also the story of how we came together as a lab to finish what Jony started.
Thiago Carvalho
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https://doi.org/10.1016/j.immuni.2022.12.002
PMID: 36580918
_ We found that unlike canonical CD8+ #TCell activation seen against viral infections where T cells rapidly acquire effector function, #tumor -specific CD8+ T cells proliferate in TDLNs but fail to express effector molecules. _
_ In human TDLNs, these cells could have been in this state for years. These undifferentiated cells instead turn on co-stimulatory receptors and several chemokine receptors and slowly migrate to the tumor._
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
