Thiago Carvalho @cyrilpedia@social.cleverlibre.org

I just found my read of the day:

https://www.biorxiv.org/content/10.1101/2022.12.31.521782v2

It makes so much sense to me that differentiation pathways in T cells(and biological processes i general) are much more flexible than currently depicted in literature! Why would a cell be fully stuck in one state with no way to return? HIgh time for studies like this to correct our current view on #immunology #memory #T cell #differentiation #gene regulation. So i look forward to read it!

Happy New Year 2023!
Our first issue brings:

#Calreticulin conformation changes in cold response

Mammalian #CDC14 #phosphatase controls #stemness exit in #pluripotent cells

#Exosomal #interleukin release via #IQGAP1-mediated #gasdermin-#ESCRT bridging

#Microglial TNFα and cortical protein #phosphorylation during #sleep

...and more:
https://www.embopress.org/toc/14602075/2023/42/1

Flore Castellan & Naoki Irie set up a transgenic mouse model to specifically deplete maternal cells in neonates. Subsequent immunophenotyping reveals that this depletion leads to early activation of splenic T and natural killer cells:

https://journals.biologists.com/bio/article/11/11/bio059334/278792/Postnatal-depletion-of-maternal-cells-biases-T

#Immunity #ImmuneSystem #AcademicMastodon #BiologyOpen #Biology #Science #MaternalCells

We found novel #papillomaviruses, that are prevalent, diverse, and with complete genomes, in the critically endangered Malayan and Chinese pangolins #paleovirology

https://royalsocietypublishing.org/doi/10.1098/rsbl.2022.0464

The painting features even more bottles with paper wrappers or paper pluggers. Have a look yourself. #PaperHistory

As this room is full of papers, almanacs glued on the wall, old paper books lying around, a broadside glued on the window shutter, another broadside glued to the wall storing also letters or comments made on paper sheets, I sense this paper re-usage to protect liquids in bottles was a common thing? Historians of early modern apothecaries, do you know more? #histodons

3/3

🆕 #HorizonEU 2023 calls for proposals for #EU funding on #food, the #bioeconomy, #naturalresources, #agriculture & the #environment are now open!

Applicants can apply by 23 March and 12 April (depending on the call).

Over €890 million is available to fund innovative solutions that support:

🍂 #biodiversity

🍎 #Healthy food

🚜 #sustainable #foodsystems

♻️ the #circulareconomy

🌍 the protection of #forests and #oceans

💨 #zeropollution

More information: https://europa.eu/!bHUYQP

It's back!
AI in Drug Discovery 2022 - A Highly Opinionated Literature Review
https://practicalcheminformatics.blogspot.com/2023/01/ai-in-drug-discovery-2022-highly.html

In Japanese Buddhist cosmology Gakido is a parallel realm, said to be one of the four unhappy rebirths. In this barren & inhospitable wasteland, a #yokai spirit known as gaki lives in terrible torment & suffering. As punishment for sins in a past life they wander this awful place, eternally hungry & thirsty. Even if they eat they'll never feel satisfied. During obon some Buddhist traditions perform ceremonies to ease the suffering of gaki.
#folklore @folklore #japodon #JapaneseFolklore

In the aging research field, probably everyone knows this review: The Hallmarks of #Aging . Now there is a revised version with brand new hallmarks! 🌟👇

https://www.cell.com/cell/fulltext/S0092-8674(22)01377-0

On #scienceTwitter, my favourite thing were reading and, on rare occasions, writing "paper/preprint threads". From the researchers I followed and through the #Twitter algorithm, this became my most important source for new #research.

While people start to do the same on #Mastodon, I have the feeling that I miss important work bc no algorithm "saves" it for me if I don't watch my timeline constantly.

Two simple solutions would be: a commonly accepted hashtag that everybody uses when writing "paper threads" or a [...] @ a.gup.pe group with a similar adaptation rate.

#Question 1: is there already a mechanism for this that I missed?
#Question 2: What hashtag or group name?
I saw #TootPrint before. Maybe #PaperInAToot? #PaperInAPost? #PaperInAThread? #PaperPost? #MastoPrint?

Suggestions and boosts, please, we need reach for this! 🤓​

#TwitterMigration #Science #Scientist @phdstudents @academicchatter @neuroscience @cognition

🚨neuro-ML internship in NYC 2023🚨

Passionate about comp neuro, neuro-AI, neural network theory, neural manifolds 🧠🤖💻?

Multiple summer intern openings at @FlatironCCN @SimonsFdn!

Recruiting both advanced undergraduate and graduate level students: https://www.simonsfoundation.org/flatiron/careers/?tab=job-openings&center=ccn

The collection of immune cell proteomes is really growing at http://ImmPRes.co.uk. Simply fantastic resource.
#Tcells (of many types)
#NKcells
#Neutrophils
#Macrophage
#Bcells
#Basophils
#TheListGoesOn

I know for a fact there’s lots of new datasets on the way too 😁
---
RT @ImmPRes_
we have now added our first #neutrophil dataset to ImmPRes. What effect does hypoxia have on neutrophils when they're activated with LPS? and what happens …
https://twitter.com/ImmPRes_/status/1610671220810203137