Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Lisbon

"To explore the feasibility of eliciting CD4+ T cell responses widely cross-recognizing different CoVs, we utilized samples collected pre-pandemic to systematically analyze T cell reactivity against representative alpha (NL63) and beta (OC43) common cold CoVs (CCC)."

#immunology #Coronavirus #Vaccines #Preprint

https://www.biorxiv.org/content/10.1101/2023.01.04.522794v1

'
The Natural History Museum has been denounced for signing a gagging order which prevented it from criticising a Danish oil company that sponsored its wildlife photography competition.

The clause was put into a contract with Dong Energy, now known as Orsted, for its sponsorship of the Wildlife Photographer of the Year competition.'

https://www.theguardian.com/culture/2023/jan/08/natural-history-museum-gagging-order-danish-oil-sponsor

"However, isolation of ‘TCR-mimic’ (TCRm) Abs is laborious because Abs have not evolved the structurally nuanced peptide–MHC restriction of αβ-TCRs. Here, we present a strategy for rapid isolation of highly peptide-specific and ‘MHC-restricted’ Abs by re-engineering preselected Abs that engage peptide–MHC in a manner structurally similar to that of conventional αβ-TCRs."

https://www.nature.com/articles/s41587-022-01567-w

"But in some residential neighbourhoods where the NEA and Verily have run field trials, it is a different story. Verily’s tech fights dengue-carrying Aedes aegypti mosquitoes with the release of other facility-bred Wolbachia-Aedes mosquitoes. The NEA has reported up to 98 per cent suppression of the Aedes aegypti population and an 88 per cent reduction in dengue cases after at least one year of releases under Project #Wolbachia, which Verily joined in 2018."

#Dengue
https://www.ft.com/content/9ee5a38f-9f5e-4434-89ec-309f6d2513ca

'In her shattered Philadelphia neighborhood, and increasingly in drug hot zones around the country, an animal tranquilizer called xylazine — known by street names like “tranq,” “tranq dope” and “zombie drug” — is being used to bulk up illicit fentanyl, making its impact even more devastating.'

https://www.nytimes.com/2023/01/07/health/fentanyl-xylazine-drug.html

"Chaotic is how I’d describe my childhood. My parents shuffled between the US and Korea. I had a tapeworm at one point. My American doctor, who had never seen one, asked to keep it. I wonder where it is – and if my name is on it."

https://www.theguardian.com/lifeandstyle/2023/jan/07/margaret-cho-i-was-never-in-doubt-that-id-do-standup

"There is one obvious way in which human neurons and their dendrites are different from dendrites in, say, cats or rats: they are bigger. However, are these anatomical differences, which alone could change the signal processing capabilities of dendrites [2.,3.], also accompanied by differences in functional properties?"

#Neuroscience #Evolution

https://www.cell.com/trends/cognitive-sciences/fulltext/S1364-6613(20)30069-3