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#NewStudy “Vaccines were generally estimated to be effective against severe outcomes caused by SARS-CoV-2 Omicron infection, this analysis found that protection in older patients was more likely to wane 6 months after the second dose. Hence, a booster dose is recommended for older patients to restore immunity” #covid19 jamanetwork.com/journals/jaman

Cover image by Madalena Parreira for JEM in 2016, based on a paper by Kuchmiy et al, "NLRP2 controls age-associated maternal fertility"

madalenaparreira.com

Hello, again! Some reintroductions in order now I've moved servers to zirk.us.

I'm Will Buckingham, a #writer based in #Dundee with a background in #philosophy and #anthropology. My latest book is HELLO, STRANGER (Granta 2021) — an exploration of the arts of #hospitality through philosophy, anthropology, #history & #culture.

I'm on the faculty at Parami University in #Myanmar and run Wind&Bones, a social enterprise working worldwide on projects about #writing, #creativity & #socialchange.

'Despite being one of the more sophisticated programs ever to run on my laptop, Whisper.cpp is also one of the simplest. If you showed its source code to A.I. researchers from the early days of speech recognition, they might laugh in disbelief, or cry—it would be like revealing to a nuclear physicist that the process for achieving cold fusion can be written on a napkin.'

newyorker.com/tech/annals-of-t

@cyrilpedia i think if we just keep increasing the total number of cells, the UMAPs shape will start resembling the organ they come from, right?

Not the point of the paper, but this intro bit was news to me:

"Indeed, the host immunity-boosting phenotype may explain the initial spread of Wolbachia in previously uninfected populations. In nematodes, elimination of Wolbachia induces host sterility, and antibiotic treatment is an effective addition to pharmacological treatment of human-infecting, -positive filarial nematodes"

journals.plos.org/plosbiology/

"These are not ordinary conservatives. They are extremist politicians who seem to celebrate the period of brutal military dictatorship, when, beginning in 1964, the military dissolved Congress, suspended constitutional rights, and imposed extensive censorship; democracy was not restored until 1985. They claim that the great mistake of the military regime was “to torture but not kill,” as Bolsonaro himself declared in 2016."
cc @mucida

nybooks.com/articles/2023/02/2

"If the governor of Florida wants a culture war, he should get one. Students and faculty must resist right-wing efforts to remake liberal arts education. The right can be defeated."

currentaffairs.org/2023/02/fig

"This review aims to consolidate past and current studies investigating the complexity of the miRNA interactome to provide the reader with a mechanistic view of how miRNAs shape macrophage behavior."

journals.aai.org/jimmunol/arti

Diego Rivera and Ferida Kahlo Leading the Contingent of the Union of Painters and Sculptors in a May Day March, Mexico City, Tina Modotti, 1929

RT @EricTopol
Rare genetic disorders in the interferon pathway and life-threatening Covid
jci.org/articles/view/166283 @jclinicalinvest by @casanova_lab and @MAndersonUCSF

New #EvolutionPaper #preprint with @iochromaland on the evolution of the #flavonoid pathway in the Petunieae clade of #Solanaceae. We use multivariate phylogenetic comparative methods to analyze quantitative measures of #GeneExpression and floral flavonoid #pigment content in a phylogenetic context. We find that #evolutionary transitions in floral pigmentation appear to be largely underpinned by shifts in gene expression, and uncover tradeoffs between pathway branches. ecoevorxiv.org/repository/view

"Three years into the pandemic, the immune systems of the vast majority of humans have learnt to recognize SARS-CoV-2 through vaccination, infection or, in many cases, both. But just how quickly do these types of immunity fade?"

nature.com/articles/d41586-023

@cyrilpedia
These papers are so important. Fabulous resource, especially given the challenges of getting these samples and costs of the single cell sequencing #crohnsdisease #immunology #IMMastodon #mucosalimmunology

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