Thiago Carvalho @cyrilpedia@social.cleverlibre.org

"An Alzheimer's disease-specific pattern of cytokine secretion reduces expression of mitochondrial electron transport complexes and impairs mitochondrial respiration in healthy neurons."

#alzheimers #Preprint

https://www.biorxiv.org/content/10.1101/2023.04.07.536014v1

'Our study reveals that probiotic Lactobacillus reuteri (Lr) translocates to, colonizes, and persists within melanoma, where via its released dietary tryptophan catabolite I3A, it locally promotes interferon-γ-producing CD8 T cells, thereby bolstering ICI.'

#Immunology #Immunotherapy

https://www.cell.com/cell/fulltext/S0092-8674(23)00271-4

"A federal judge in Texas has taken a shocking and irresponsible action:invalidating the Food and Drug Administration’s approval of mifepristone, a medication used safely by hundreds of thousands of women each year to help terminate pregnancies as part of a two-pill regimen."

https://www.nytimes.com/2023/04/10/opinion/fda-mifepristone.html

'Using single i-cell transplantation from transgenic fluorescent donors to wild-type recipients, we find that these cells are pluripotent. Under physiological conditions, a single i-cell can differentiate into all somatic cell types and into gametes. The presence of embryonic-like, pluripotent cells throughout adult life facilitates their ability to grow indefinitely in a plant-like fashion.'

https://www.cell.com/current-biology/fulltext/S0960-9822(23)00404-9

'El área metropolitana de Delhi, la ciudad más poblada de la India, tiene la misma superficie que Badajoz. En ella residen 29 millones de personas, dos tercios de las de toda España.'

https://elpais.com/internacional/2023-04-09/por-que-la-india-ya-supera-a-china-en-habitantes-asi-es-la-explosion-demografica-del-pais-de-las-megaciudades.html

“Libraries have been around for thousands of years; they are older than copyright law itself,” the Electronic Frontier Foundation, which is representing the IA, wrote in its brief. “Never in the history of the United States have libraries needed to obtain special permission or to pay license fees to lend the books they already own.”

https://www.theatlantic.com/ideas/archive/2023/04/internet-archive-libraries-federal-court-ruling/673615/

FENS/IBRO-PERC Exchange Fellowships Programme of up to €4k for lab exchange.
Deadline April 15
#Neuroscience

https://www.fens.org/careers/grants-and-stipends/grant/fens-ibro-perc-exchange-fellowships

'Experts often cite mistrust of the government as a key reason certain communities ‌have suffered disproportionately during deadly outbreaks, including Ebola and Covid-19. Mistrust is a serious problem in a pandemic if it prevents people from obeying health recommendations, seeking medical care and accepting vaccines.'

https://www.nytimes.com/2023/04/09/opinion/brazil-favelas-pandemic-trust.html

'Most of these studies have focused on immune checkpoint blockade, although effects of the microbiota on clinical outcomes have also been observed in allogeneic hematopoietic stem cell transplant (which can be considered a very broad form of #immunotherapy).'

#Immunology #CARTcells

https://www.nature.com/articles/s41591-023-02272-0

'It took García Márquez only 18 months to write “Solitude,” though he spent nearly two decades mulling the story in his head. While reading proofs of his novella “Leaf Storm” — an early testing ground for Macondo and its characters — he remarked to his brother, “This is good, but I’m going to write something that people will read more than the Quixote.” He wasn’t far off.'
https://www.nytimes.com/article/gabriel-garcia-marquez-books.html