Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'We demonstrate that while male NK cells display enhanced cellular fitness in mice, they show decreased effector function in mice and humans. These sex biases in NK cell composition and function were not completely due to hormonal differences, because they persisted in gonadectomized mice'

#Immunology #InnateImmunity #NKcels

https://www.nature.com/articles/s41590-023-01463-8

@ct_bergstrom

2. There is a very honest description of scientists' motivations. We are all "epistemically sullied", motivated by both curiosity AND desire for recognition.

It is critical to acknowledge this as we seek to reenvisage publishing. Denying the fact (how it drives pursuit of JIF, CNS, h index, competition, etc.) won't help us. The key is to understand this and then think how the system can be improved so distortions (Goodhart's Law, etc.) are minimized.

3/3

This is exciting:
"...In this Article, we show that gut-specific telomerase expression in tert−/− zebrafish is sufficient to delay gut aging. Counteracting gut aging improves health of the entire organism, reverting gut microbiota dysbiosis and aging phenotypes in distant organs of tert−/− zebrafish"
https://rdcu.be/dbo2E

Interplay Between Polymorphic Short Tandem Repeats and Gene Expression Variation in Caenorhabditis elegans https://doi.org/10.1093/molbev/msad067 #science #evolution #biology #genome #SciComm #evolgen_paper

"A "very concerning" rise in the number of people catching measles in the UK has been reported by health officials.

The virus spreads incredibly easily and a fall in vaccination rates is leaving more children vulnerable."

Get Vaccinated.
#VaccinesWork
https://www.bbc.co.uk/news/health-65481976

@ct_bergstrom

1. There's a great explanation of the oft-cited Why Most Published Research Findings are False paper by John Ioannidis that explains why assumptions made about how scientists general hypotheses mean this is not correct.

Others have pointed this out but Carl and Jevin give a very clear explanation of why, which is important given how frequently and uncritically this work is cited in our sphere 2/3

Calling Bullshit by @ct_bergstrom is a fascinating read that brilliantly summarizes issues around data interpretation, various logical fallacies, phony graphs, and misleading statistics.

That alone makes it essential reading but two other things stood out for me that may interest sci comm/publishing types. 1/3

90% of cancers reactivate telomerase. In our new preprint, we reveal that tumors that fail to activate telomerase trigger a stronger immune response, leading to melanoma regression. Our work also sheds light on the association between telomerase gene mutations and the immune system and provide a mechanism to explore the success of immunotherapies.

🐟 #zebrafish 🧬#telomerase 💊#immunotherapy 🔬#cancerresearch https://www.biorxiv.org/content/10.1101/2023.03.24.534079v1

💥learn science from one of the best💥
---
RT @HarmitMalik
We have 2 res. tech. openings in our lab starting soon. Please RT & bring this to the attention of students interested in getting hands-on experience in the lab before heading to grad/ med school. We value curiosity, mentorship, & diversity.

1st position: https://jobrxiv.org/job/research-technician-i-malik-lab/
https://twitter.com/HarmitMalik/status/1654238564752973824

Out now! 👇Over a century ago, Elie Metchnikov proposed that #aging is caused by increasing #intestine permeability and toxic #microbiota into our bodies. In our last paper provides evidence for this idea and a potential mechanism for “inflammaging”. #IRCAN #IGC #CNRS #zebrafish 🐟 https://doi.org/10.1038/s43587-023-00401-5

'A recent American study found that an elite class of principal investigators who hold three or more concurrent NIH (National Institutes of Health) grants grew in number over the past 30 years but, even after controlling for career stage and degree, women were significantly underrepresented. And despite evidence of diminishing returns for annual grants over US$600,000, the dollars remain concentrated in the hands of a select few.'

https://www.theguardian.com/commentisfree/2023/may/04/put-a-man-on-it-the-very-short-story-of-my-medical-research-career

'For patients in a late-stage trial, the drug called donanemab slowed progression of the disease by 35 per cent compared with those who took the placebo during an 18-month treatment period. The decline in patients’ ability to perform daily tasks was 40 per cent lower for those on the drug.

However, the drug displayed severe side effects such as brain swelling and bleeding and three people on the trial died.'
#alzheimers #alzheimersdisease

https://www.ft.com/content/11a59576-e057-433a-b1f9-393159bda85c

https://www.science.org/doi/10.1126/science.adh7699

UKHSA is doing a study to try to map out immunity to #mpox. It had been assumed mpox was a one-and-done type of infection, but there have been a few reports of what looks like repeat infections, like this recent paper in Lancet. https://www.thelancet.com/action/showPdf?pii=S1473-3099%2823%2900185-8 and https://www.gov.uk/government/news/study-launched-to-find-out-more-about-mpox-immunity

'In any case, it is remarkable that senolysis of a small fraction of senescent osteocytes may account for the robust bone-protective effect, further supporting the importance of osteocytes for bone metabolism and skeletal health. Given their crucial role in orchestrating bone remodeling and their high degree of connection, these few senescent osteocytes may be sufficient to cause functional chaos through cellular miscommunication.'

https://www.jci.org/articles/view/169069