Thiago Carvalho @cyrilpedia@social.cleverlibre.org

'A similar percentage of deaths from the same side effect followed in the clinical trial of Leqembi, an F.D.A.-approved Alzheimer’s drug from the company Eisai. A third drug, Aduhelm, was also approved by the F.D.A., but is rarely used because of concerns about its effectiveness and its high price. Brain swelling was reported in its clinical trial and deaths were reported in patients taking Aduhelm after it was approved.'

https://www.nytimes.com/2023/05/03/health/alzheimers-drug-eli-lilly-trial.html

'GSDM (the gene encoding gasdermin) and GSDM-like genes are evolutionarily ancient and have been identified across a wide range of animal and nonanimal species, including fungi and bacteria.'

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002103

'The European People’s party, which has the most seats in the European parliament and is in power in nine countries across the EU, will call on Friday to scrap two flagship pieces of legislation put forward by their own European Commission president, Ursula von der Leyen. The move could torpedo the commission’s plans to cut pesticide use in half and rewild a fifth of damaged habitats across the bloc by 2030.'

https://www.ft.com/content/38f5801e-a68c-4328-b467-a07ee7fbd94d

'Why was the Celera compound initially neglected? Because it was only years later that researchers at the US government’s National Institutes of Health (NIH) showed that overactive BTK drove the growth of CLL and certain lymphomas, so blocking it would inhibit these cancers. When Celera sold it to Pharmacyclics, it didn’t have any apparent application.'

https://www.nybooks.com/articles/2023/05/25/saving-lives-and-making-a-killing-for-blood-and-money-vardi/

'These distinct roles for EZH2 in promoting prostate cancer progression, metastasis, and AR independence raise the possibility that it could be a potential therapeutic target in advanced disease.'

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002038

'Britain’s biggest biomedical charity is to triple the size of its genetics and biological data facilities near Cambridge, in one of the largest investments in UK research infrastructure'

https://www.ft.com/content/b2d3f6a8-7e1f-48f3-a298-6588c56d91bc

@miguelgf I leave the adamantium to Wolverine.

"Menopause costs American women an estimated $1.8 billion in lost working time per year, according to a Mayo Clinic study published this week. The paper examined how hot flashes, night sweats, mood swings and the myriad other symptoms associated with this time of life affect women in the workplace. It’s the largest study of its kind to have been done in the United States."

https://www.nytimes.com/2023/04/28/well/live/menopause-symptoms-work-women.html?action=click&module=Well&pgtype=Homepage&section=Well