Thiago Carvalho @cyrilpedia@social.cleverlibre.org

@proteomicsnews blog post | Proteomics reveals that METH (yes, real METH) is bad for mice! And why! | https://proteomicsnews.blogspot.com/2023/09/proteomics-reveals-that-meth-yes-real.html #proteomics

Interested in associative memory and hopfield networks? Join us for the AMHN workshop at Neurips, linking #neuroscience and #ML #AI . I am very excited to support the organisers as part of the program committee!

General information:

https://amhn.vizhub.ai

Call for papers:

https://amhn.vizhub.ai/cfp/

An intracellular #LiquidCondensate formed in plants by #LipidTransferase SFH8 associates with membranes; SFH8 cleavage by #Caspase-like protease ESP turns it into a solid filament that can modulate root development @Panosmoschou @Chenliu06 &co #PLOSBiology https://plos.io/3sZkIY0

Assistant Professor

Yale School of Medicine - Department of Microbial Pathogenesis

The Department of Microbial Pathogenesis at Yale School of Medicine seeks candidates for tenure-track assistant professor position(s)...

See the full job description on jobRxiv: https://jobrxiv.org/job/yale-school-of-medicine-department-of-microbial-pathogenesis-27778-assistant-profe...
https://jobrxiv.org/job/yale-school-of-medicine-department-of-microbial-pathogenesis-27778-assistant-professor/?feed_id=59216

So #DORA has almost 24k signatures now:

https://mastodon.world/@DORAssessment/111088194624414428

Only 3k of those are from institutions. Globally, the number of academic institutions is close to 90k:

https://higheredstrategy.com/higher-education-institutions-worldwide/

DORA is now 10 years old:

https://sfdora.org/dora-10th-anniversary-events/

At the current rate of about 300 institutional signatories per year, it will take another 140 years until 50% of all institutions have signed DORA.

This is the speed of #openscience

The length of motorways in Europe grew 60% between 1995 and 2020 while railways shrank 6.5%. For every €1 governments spent building railways, they spent €1.6 building roads.

https://www.theguardian.com/world/2023/sep/19/european-governments-railways-road-building-report-motorways-funding-rail?CMP=Share_iOSApp_Other

'However, it is well-established that, compared with other conventional treatments, immunotherapy shows unique efficacy kinetics such as delayed clinical effect and long-term favorable outcome.3 These characteristics may lead to the prolongation of trial duration and make it difficult to accelerate the drug development process.'

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00333-4/fulltext#secsectitle0100

I hate it when that happens

"He recounts the grudge he held on behalf of his father, Thyestes, whom Agamemnon’s father, Atreus, had tricked into eating his own children."

https://www.nytimes.com/2023/09/12/magazine/greek-tragedy.html

'That book’s philosophical themes, however, continued to percolate and eventually emerged in an entirely different form in a series of stories called Artifices (1944). In that collection’s opening story, Borges describes a man who loses his ability to forget.'

https://aeon.co/essays/borges-and-heisenberg-converged-on-the-slipperiness-of-language

'Following Joseph Lister, German surgeons, unlike their French colleagues, used carbolic acid spray to sterilise their tools and operating areas. French surgeons did insist on ‘hygiene’, but by this they meant the provision of adequate bedding and the maintenance of medical supplies, not sterilisation. Death rates for amputations on the French side reached 75 per cent (including toes and fingers) – a shocking figure, given that by 1870 the use of Lister’s techniques in peacetime amputations had resulted in a drop from 50 per cent to 15 per cent.'

https://www.lrb.co.uk/the-paper/v45/n18/christopher-clark/predicamental

Cephalopod ceramics, glazed stoneware by @hunchbacksociety

https://hunchbacksociety.cargo.site/Small-talk

#Ceramics #Handmade #Art #stoneware #artgallery #artmastodon

'Limitations relative to absolute age, time from doctoral degree, and/or duration of postdoctoral training arbitrarily select against early-stage investigators who have taken nonlinear or nontraditional career paths.'

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002291

@thelancet #SARSCoV2 is capable of #neuroinvasion into the hypothalamus through at least 2 distinct invasion routes➡️resulting dysfunction of GnRH-neurons & tanycytes(special ependymal cells in the 3rd ventricle of 🧠 & on the floor of 4th ventricle & processes extending deep into the hypothalamus. be responsible for serious reproductive, metabolic, mental health consequences in LC pts ➡️ lead to a delayed increase in the risk of neurodevelopmental & neurodegenerative pathologies in all age groups

“A new type of vaccine… has shown in the lab setting that it can completely reverse autoimmune diseases like multiple sclerosis and type 1 diabetes—all without shutting down the rest of the immune system.”

Leveraging the liver!

https://erictopol.substack.com/p/an-exciting-new-approach-to-autoimmune