Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Number of #LongCOVID Cases Could Be Vastly Underestimated

“new research suggests that may be an underestimate and that far more people may be suffering from long #COVID without ever having tested positive for the virus. Researchers found a significant proportion of patients in their small study who had never tested positive for COVID-19 but who were having symptoms of long COVID nevertheless showed evidence of immune responses consistent with previous exposure.”

https://www.medscape.com/viewarticle/995895

Single-cell omics techniques to elucidate cell-to-cell variability in signaling cascades involved in human diseases https://www.tandfonline.com/doi/full/10.1080/14789450.2023.2268836

---
#proteomics #prot-paper

Following on from Friday's numbers substack post, I've just done a dive into all the data we used to have about Covid and what it meant.

Hopefully useful when considering what's coming out of the Inquiry about decisions in 2020! We knew a lot!

https://open.substack.com/pub/christinapagel/p/here-yesterday-gone-today-data-of?r=8zv6v&utm_campaign=post&utm_medium=web

"One of my hobbies is reading really old scientific papers. When I realized that uridine in RNA sets off immune cells, resulting in inflammation and interferon production, I wondered whether anyone had noticed this before. So I went back to the literature. Sure enough, I found a 1963 paper in which the authors reported that RNA isolated from mammalian cells does not induce the production of interferon (5). However, when the RNA was treated with nitrous acid, which deaminates all of the cytidines to uridines, it induced interferons. It gave me great pleasure to see that these researchers had stumbled upon this observation years before."

https://www.pnas.org/doi/10.1073/pnas.2119757118

"And in evolutionary terms, species don’t really get a harder problem than the one we have to deal with: Human beings are really, really bad at reproducing ourselves. Even today, with modern medical interventions, our pregnancies and births—and, as a result, our postpartum recoveries—are longer, harder, and more prone to crippling complications than they are for most other primates."

https://www.theatlantic.com/books/archive/2023/10/gynecology-human-ancestors-eve-bohannon/675526/

"A razão mais importante para dar a estocada final nesta política é que os impostos estão no cerne da democracia. O ato cidadão de contribuir, cada um na medida das suas possibilidades, para que o Estado possa fornecer serviços públicos e proteger os mais frágeis é fundador da nossa vida em sociedade."

https://www.publico.pt/2023/10/06/opiniao/opiniao/fim-borla-fiscal-rnh-so-acredito-2065725

"La trama presuntamente vendía la autoría de estos cientos de estudios falsos a investigadores asiáticos, sobre todo indios y chinos, ávidos por publicar rápidamente para lograr una plaza o un ascenso. La red lograba entonces colar esos pseudoestudios en revistas especializadas de las principales editoriales científicas, como Elsevier, Springer Nature, Wiley y MDPI. Más que aprovechar las grietas del sistema, estaban paseando por una alfombra roja para los tramposos."

https://elpais.com/ciencia/2023-10-05/una-megafabrica-de-estudios-cientificos-falsos-salpica-a-un-vicerrector-espanol-y-a-tres-colaboradores.html

'In this study, we investigate the role of microbiota-derived acetate in the regulation of O-GlcNAcylation and HCC progression under high fructose consumption. We report that fructose promotes HCC progression by enhancing O-GlcNAcylation via microbiota-derived acetate.'

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00340-6

'Disinformation campaigns — some armed with AI-generated deepfakes — are likely to be rampant in the coming months, says Ulrike Klinger, who studies political communication at the European University Viadrina in Frankfurt (Oder), Germany. “And we cannot monitor them because we don’t have access to data.”

https://www.nature.com/articles/d41586-023-03102-6

'In a bid to stem the resurgence of sexually transmitted infections, the Centers for Disease Control and Prevention plans to recommend doxycycline, a widely used antibiotic, for use after an unprotected sexual encounter.'

https://www.nytimes.com/2023/10/03/health/doxycycline-syphilis-gonorrhea-chlamydia.html

'RNA’s fleeting nature isn’t a big problem for a vaccine: it needs to encode proteins only for a short time to trigger an immune response. But for most therapeutic applications, it would be much better to have RNA that could stick around for longer.'

https://www.nature.com/articles/d41586-023-03058-7

Faculty Position, Department of Pediatric Medicine - Division of Anesthesiology

St. Jude Children's Research Hospital

See the full job description on jobRxiv: https://jobrxiv.org/job/faculty-position-department-of-pediatric-medicine-division-of-anesthesiology-5/?feed_id=60996

#ScienceJobs #hiring #research
Memphis #UnitedStatesUS #FacultyMember #GroupLeader #PrincipalI...
https://jobrxiv.org/job/faculty-position-department-of-pediatric-medicine-division-of-anesthesiology-5/?feed_id=60996

My brilliant colleague Benjamin Judkewitz tells us all about the smallest brain in the singing fish Danionella. #imaging #berlin #optogenetics

Registration for the Michael Ashburner memorial symposium is now open. https://www.eventbrite.co.uk/e/michael-ashburner-memorial-symposium-tickets-728856127297?aff=oddtdtcreator

Amazon and other online retailers will start charging customers in France a minimum delivery fee of €3 when ordering books online from Saturday when a new law comes into effect to support independent booksellers.

Before, Amazon charged a single euro cent for delivery.

The measure aims to give independent booksellers a fighting chance at competing with big tech companies like Amazon.

https://www.euronews.com/culture/2023/10/06/france-makes-amazon-charge-3-delivery-fees-to-protect-indie-bookstores

#France #Amazon #OnlineRetail #Books #BookStores #BigTech

Bernd has been pushing this point for a while, and I think he is right. Self correction is an important part of the scientific process and journals, funders, and institutions need to do more to encourage it.

'What can journals do to support both self-correction by authors and by the community? We have discussed this matter for a decade at EMBO Press, culminating in a workshop that recommended to make an explicit distinction between an author initiated- and an externally initiated- or even forced retraction. We use the term “withdrawal” for the former and reserve “retraction” for the latter.'
#scientificpublication #ResearchIntegrity
@emboreports

https://www.embopress.org/doi/full/10.15252/embr.202358155