Thiago Carvalho @cyrilpedia@social.cleverlibre.org

Commissioner Breton writes a letter

In praise of the one-page formal document

By me at Substack

https://emptycity.substack.com/p/commissioner-breton-writes-a-letter

Job ad: 2 Postdoc positions ecology - Bern Switzerland
@jobsecoevo
#postdoc position in #ecology #biodiversity #synthesis in Bern #Switzerland
Links:
https://ohws.prospective.ch/public/v1/jobs/12743982-1bbc-4488-b11e-137a80ef8d65
https://ohws.prospective.ch/public/v1/jobs

"Increasing electron flow through mitochondrial complex I elevated succinate levels and led to transcriptional and epigenetic activation of major histocompatability complex class I (MHC-I) and antigen presentation and processing genes."

#immunology #Metabolism #immunotherapy

https://www.science.org/doi/full/10.1126/science.abq1053?casa_token=SZbtchll28kAAAAA:p7udtIgkRaaOPftkYr8CucYflxIxK7VmU-t65vT2c23vJkSgmUPNGcskrqo8Q_CwVDlmsv4t0MPoiIY

"Using evidence in skeletons of people who died in the 1918 outbreak, researchers reported that people who suffered from chronic diseases or nutritional deficiencies were more than twice as likely to die as those who did not have such conditions, no matter their age."

https://www.nytimes.com/2023/10/09/health/1918-flu-skeletons.html

"Aortic aneurysms occur six times more often in men than women. But if a woman does have one, it’s more likely to burst, she’s less likely to get effective treatment and more likely to die. These outcomes are a tangle of sex (influenced by chromosomes, physiology and hormones) and gender (how we identify, behave in our environment and interact with one another). Why is our society calibrated for men so that women receive substandard medical care? And why are researchers not studying half the world’s population who are excellent at not getting aneurysms?"

https://www.theguardian.com/books/2023/oct/10/eve-how-female-body-drove-200-million-years-of-human-evolution-by-cat-bohannon-review

Postdoc fellow- Computational Biology, University of Chicago

University of Chicago

Come join us at #UChicago as a #bioinformatics postdoc, working on #human genetics and #functional genomics.

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-chicago-27778-postdoc-fellow-computational-biology-university-of-chicago/?feed_id=61690

#Scienc...
https://jobrxiv.org/job/university-of-chicago-27778-postdoc-fellow-computational-biology-university-of-chicago/?feed_id=61690

"Unexpectedly, approximately 15% of the steady state population of hTR has a CR4/5 conformation lacking features required for hTERT binding. Mutagenesis demonstrates that stabilization of the alternative CR4/5 conformation is detrimental to telomerase assembly and activity. We propose that this misfolded portion of the cellular hTR pool is either slowly refolded or degraded."

#Preprint #Telomeres #Telomerase

https://www.biorxiv.org/content/10.1101/2023.10.04.560962v1

"Nobel announcement disagreements often focus on whether the recipients deserved it, or not. But the 2023 Medicine and Physiology prize has received near universal applause: the science that it rewards has already saved the lives of many millions, and (maybe most importantly) has transformed how we think about emerging infectious diseases and other diseases. But the real intrigue surrounds its backstory. Karikó was forced to retire from her position at the University of Pennsylvania in 2013. The much-discussed reasons are familiar villains: the inability to secure major grant funding from the large agencies, and other markers of success in the biomedicine machine."

https://www.scientificamerican.com/article/nobel-prize-debate-misses-the-mark-on-the-real-culprits-ignoring-scientific-merit/?utm_source=twitter&utm_campaign=socialflow&utm_medium=social

@cyrilpedia i was actually just reading this. I thought the finale was poignant and correct...

"And while on a good day we can kid ourselves that it doesn’t truly matter … on the bad days, when the chips are down, it really, really does."

One can largely insulate oneself from the chaos on Twitter / X, but sadly supporting it in its current state has negative consequences.

Here is an image of today's warning letter to Elon Musk from the European Commission:

The EU has issued an urgent warning to Elon Musk, giving him 24 hours to respond.

Guardian: EU warns Elon Musk over ‘disinformation’ on X about Hamas attack >>> https://www.google.com/amp/s/amp.theguardian.com/technology/2023/oct/10/eu-warns-elon-musk-over-disinformation-about-hamas-attack-on-x

"Let me remind you that the Digital Services Act sets very precise obligations regarding content moderation..."

"Failing to moderate content such as fake news could incur fine of 6% of X revenues or EU blackout under new laws"

#Twitter #misinformation #moderation #FakeNews

"Desde hace tiempo, las principales zonas de cultivo europeas han visto reducir tanto sus cosechas como la calidad del lúpulo por culpa del trastorno climático. Proyectado hacia el futuro, el trabajo señala a las plantaciones de España y otros países del sur de Europa como las más afectadas por el calentamiento."

https://elpais.com/ciencia/2023-10-10/el-sabor-y-el-aroma-de-las-cervezas-europeas-estan-amenazados-por-el-calor.html

'Here’s what infectious disease experts want you to know about some of the most common adult and pediatric viruses (and one bacterial infection): their symptoms, how they spread, how to treat them and when you (or your child) can re-enter society.'

https://www.nytimes.com/interactive/2023/10/06/well/live/contagious-cold-flu-virus-illness.html

Column in The Guardian about high speed rail in Spain https://www.theguardian.com/commentisfree/2023/oct/11/spains-high-speed-trains-arent-just-efficient-they-have-transformed-peoples-lives?CMP=Share_iOSApp_Other

The penultimate paragraph is the crucial one - the network works if you’re going between cities. It doesn’t if you’re going to smaller places or don’t want to go via Madrid.

Very nice review on amphioxus biology https://elifesciences.org/articles/87028 #amphioxus #EvoDevo