Thiago Carvalho @cyrilpedia@social.cleverlibre.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Interesting mix:
"She discusses famous nineteenth-century figures such as Rudolf Virchow, the German physician widely credited as the founder of modern pathology, and Elie Metchnikoff, the Russian zoologist who discovered how white blood cells neutralize invading bacteria, as well as less familiar researchers like Ruslan Medzhitov, Gökhan Hotamışlıgil, and Luigi Ferrucci."
https://www.nybooks.com/articles/2023/12/07/gut-instincts-a-silent-fire-shilpa-ravella/
Thiago Carvalho
boosted
A new preprint discussing "The evolutionary puzzle of human twinship"
"We propose that a historical dynamic of gene-culture coevolution might explain...the sizeable variation in twinning rates observed between human populations"
"However, in our large study, including over 1000 patients with metastatic breast cancer undergoing genomic sequencing, after accounting for the confounding factor of ER expression, we did not identify any significant difference in gene mutations, CNV, nor in TMB between HER2-low and HER2-0 breast tumors, except for a higher ERBB2 copy count expectedly found in HER2-low tumors."
"Here, we present key findings, procedures, effective measures and recommendations for generating and establishing sustainable life science resources based on the collaborative, cross-disciplinary work done within the EOSC-Life (European Open Science Cloud for Life Sciences) consortium."
Nooooo!
"Stop-motion animation studio Aardman is running out of clay, it has emerged. According to a report in the Daily Telegraph, Aardman has been left with enough animation clay for one more feature film after the manufacturers of its favourite material closed down earlier this year."
'Chaimite no Arco da Rua Augusta, entre as 08h00 e as 09h00.' Photo ALFREDO CUNHA.
https://www.publico.pt/2023/11/19/politica/prepublicacao/25-abril-1974-quintafeira-2070480
"In 1987 Reagan appointed a presidential commission on the epidemic, composed of cronies and cranks ‘whose lack of experience was matched by their reckless beliefs’, France writes: it included a New York cardinal, a supporter of quarantine laws for PWAs, and a proponent of the toilet seat theory. When, against the odds, and thanks to the unforeseen (even by him) leadership of James Watkins, a retired admiral, the commission produced a wide-ranging report of 576 recommendations, one of which was to triple the federal budget to $20 billion (‘seven tenths of 1 per cent of the defence budget’), Reagan ignored it."
https://www.lrb.co.uk/the-paper/v40/n18/tom-crewe/here-was-a-plague
Thiago Carvalho
boosted
Born in 1918, Gertrude Elion faced discrimination in #science, unable to get a job as a woman. So she volunteered as a lab dishwasher, earning enough $ for grad work at NYU, where she was the only woman in chemistry classes.
Eventually Elion helped revolutionize medicine w George Hitchings. They figured out how to interfere with cell growth, leading to effective drugs for treating leukemia, gout, malaria, herpes & more, earning a 1988 Nobel Prize. https://www.acs.org/education/whatischemistry/women-scientists/gertrude-elion.html #HistoryRemix #history
Thiago Carvalho
boosted
Indian Physicist C.V. Raman died #OTD in 1970.
Using a spectrograph that he developed, he and his student K. S. Krishnan discovered that when light traverses a transparent material, the deflected light changes its wavelength and frequency. This phenomenon, a hitherto unknown type of scattering of light, was subsequently termed the Raman effect or Raman scattering. Raman received the 1930 Nobel Prize in Physics. via @wikipedia
Thiago Carvalho
boosted
On this day in 1968: Martha Wollstein born, pioneering padeiatric pathologist, developed antiserum to treat meningitis #WomenInBiotech
"Human cells express TRIM5α that restricts HIV-1. HIV-1 M evolved to escape this restriction by binding cyclophilin A (CYPA) to the viral core. Our data indicate that nonpandemic HIV-1s are sensitive to human TRIM5α."
#HIV #immunology #InnateImmunity
"Safety teams within the company pushed to slow things down. These teams worked to refine ChatGPT to refuse certain types of abusive requests and to respond to other queries with more appropriate answers. But they struggled to build features such as an automated function that would ban users who repeatedly abused ChatGPT. In contrast, the company’s product side wanted to build on the momentum and double down on commercialization."
https://www.theatlantic.com/technology/archive/2023/11/sam-altman-open-ai-chatgpt-chaos/676050/
Thiago Carvalho
boosted
Rishi Sunak thought government should ‘let people die’, Covid inquiry told | The Independent
Sunak believed it was ‘okay’ to ‘just let people die’, according to diaries from the former chief scientific adviser https://www.independent.co.uk/news/uk/politics/rishi-sunak-covid-inquiry-boris-johnson-b2450548.html
Bad news for Bayer's factor XIa inhibitor.
"The German company on Monday said its Oceanic trial studying asundexian as a treatment for atrial fibrillation had shown “inferior efficacy” compared with standard treatment."
https://www.ft.com/content/86e6009a-a252-4a52-a4e4-930a50ef2d5a
Thiago Carvalho
boosted
Measles warning amid 'devastating resurgence' of life-threatening diseases as vaccination rates miss targets
#IDMastodon #medicine #InfectiousDiseases #vaccine #vaccination #measles
> The Royal College Of Paediatrics And Child Health said many doctors would not have previously seen symptoms associated with measles in their careers.
Thiago Carvalho
boosted
Provenance and Clinical Benefit of Medicines Introduced to the French Market, 2008 to 2018
"...three-fourths of the new #medicines entering the French market between 2008 and 2018 delivered no additional clinical benefit..."
"...medicines originating in the academic setting were graded to have better clinical benefit than those originating in the commercial setting..."
Thiago Carvalho
boosted
The world’s 1st gene therapy for #sicklecelldisease has been approved in the UIK. Casgevy (jointly created by #CRISPRTX & #Vertex #pharma is the first #medicine licensed using the gene editing tool #CRISPR, & offers hope to 1000's as an alternative to the treatment of arduous #bone marrow #transplants.
https://apnews.com/article/sickle-cell-gene-therapy-treatment-uk-first-9bcf7c7d8b8909fb06e137fee17c767c
Thiago Carvalho
boosted
#IDMastodon #Immunology #viralimmunology A summary of A viral #RNA molecule activates the bacterial immune system during infection& how bacterial cyclases sense infection sense.
https://www.nature.com/articles/d41586-023-03364-0?utm_medium=Social#ref-CR3
Viral infection triggers the production of cyclic GMP–AMP synthase (cGAS), an enzyme that synthesizes cyclic GMP–AMP (cGAMP) to activate the downstream effector response.
https://www.science.org/doi/epdf/10.1126/science.1232458
Thiago Carvalho
boosted
How many #species are there on Earth? Projections have ranged from the millions to the trillions.
This Perspective looks at how a 2011 #PLOSBiology study transformed this field and what still needs to be done to find a definitive answer.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
