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Fast alignment of mass spectra in large proteomics datasets, capturing dissimilarities arising from multiple complex modifications of peptides - BMC Bioinformatics bmcbioinformatics.biomedcentra

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#proteomics #prot-paper

"Human cells express TRIM5α that restricts HIV-1. HIV-1 M evolved to escape this restriction by binding cyclophilin A (CYPA) to the viral core. Our data indicate that nonpandemic HIV-1s are sensitive to human TRIM5α."

pnas.org/doi/10.1073/pnas.2306

Nooooo!

"Stop-motion animation studio Aardman is running out of clay, it has emerged. According to a report in the Daily Telegraph, Aardman has been left with enough animation clay for one more feature film after the manufacturers of its favourite material closed down earlier this year."

theguardian.com/film/2023/nov/

"Based on this reconstruction and using as input the changes in the metabolome observed in our cohort, we obtained a comprehensive view of the impact of COVID-19 on the entire human metabolism"

journals.plos.org/plospathogen

Andrew and Silas Chandler have a story that is both unique and representative of the complex relationships that existed during the American Civil War era. Andrew was a white Confederate soldier from Mississippi, and Silas was an enslaved African American man owned by Andrew's family.

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Image: pbs.org/video/history-detectiv

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There is an iconic photograph of a black man in what resembles a confederate uniform. It suggests that he was a confederate soldier. In reality, he was a slave. This misrepresentation obscures complex and often painful truths of history, replacing them with a simplified and inaccurate account.

To read uninterrupted text: open.substack.com/pub/400years

Video Blog: youtube.com/@400YearsUNLeashed

Video Blog 2: youtube.com/@BlackBiographics?

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Image: Clark Lee, an enslaved black man to a Confederate white officer,

Swedish Unions vs Musk.
Elon’s about to find out what workers rights look like

So excited to be teaching my Science Behind Bias in STEM course again this spring! If you want to teach a similar course we share our resources and even a paper we published on how to teach similar courses in any discipline: blogs.cornell.edu/moreaulab/sc

December 2023 issue of Trends in Neurosciences:
cell.com/issue/S0166-2236(22)X

Free featured articles, collections & more:
cell.com/trends/neurosciences/

On the cover:
‘Curiosity-driven exploration: foundations in neuroscience and computational modeling’

by Alireza Modirshanechi , Kacper Kondrakiewicz, Wulfram Gerstner & Sebastian Haesler
cell.com/trends/neurosciences/

"We showed that treatment with an agonist against the tumor necrosis factor (TNF) receptor superfamily member CD40 in combination with a soluble β-glucan (BG), which targets the C-type lectin receptor (CLR) Dectin-1, was sufficient to trigger productive immunosurveillance in ICB-resistant mouse models of pancreatic ductal adenocarcinoma."

science.org/doi/full/10.1126/s

Portugal & TB

"A médica recorda que o nosso país "tem estatuto de baixa incidência a nível a mundial, mas é o que tem a incidência mais elevada na Europa Ocidental", e esta situação não pode ser esquecida."

dn.pt/sociedade/tuberculose-ai

'Hungarian Prime Minister Viktor Orbán has launched a national consultation in which he links further EU aid to Ukraine to Brussels unblocking funds for his own country, at a moment when Kyiv is struggling to secure future support from its western allies.'

ft.com/content/62286134-7f91-4

Postdoctoral Fellow/Researcher in Computational Biology & Gene Regulation

Centre for Molecular Medicine Norway (NCMM), University of Oslo

Postdoc to develop #deeplearning models to enhance JASPAR and gene regulation discoveries

See the full job description on jobRxiv: jobrxiv.org/job/centre-for-mol...
jobrxiv.org/job/centre-for-mol

Fun facts about #Texas. Elon Musk's foundering social-media platform is neither incorporated nor headquartered there. But that's where he has chosen to sue Media Matters (based in Washington, DC), and that's where the state's attorney general—currently under indictment and out on bail—is using taxpayer money to support him.

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